Abstract:
:Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-vergence gaze shifts or during blinks. Some subjects may produce saccadic oscillations at will, usually with convergence. Pathological, involuntary saccadic oscillations such as flutter and opsoclonus are prominent in certain diseases. Our recent mathematical model of the premotor circuit for generating saccades includes brainstem burst neurons in the paramedian pontine reticular formation (PPRF), which show the physiological phenomenon of post-inhibitory rebound (PIR). This model makes saccadic oscillations because of the positive feedback among excitatory and inhibitory burst neurons. Here we review our recent findings and hypotheses and show how they may be reproduced using our lumped model of the saccadic premotor circuitry by reducing the inhibitory efficacy of omnipause neurons.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Ramat S,Leigh RJ,Zee DS,Shaikh AG,Optican LMdoi
10.1016/S0079-6123(08)00616-Xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
123-30eissn
0079-6123issn
1875-7855pii
S0079-6123(08)00616-Xjournal_volume
171pub_type
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