Applying saccade models to account for oscillations.

Abstract:

:Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-vergence gaze shifts or during blinks. Some subjects may produce saccadic oscillations at will, usually with convergence. Pathological, involuntary saccadic oscillations such as flutter and opsoclonus are prominent in certain diseases. Our recent mathematical model of the premotor circuit for generating saccades includes brainstem burst neurons in the paramedian pontine reticular formation (PPRF), which show the physiological phenomenon of post-inhibitory rebound (PIR). This model makes saccadic oscillations because of the positive feedback among excitatory and inhibitory burst neurons. Here we review our recent findings and hypotheses and show how they may be reproduced using our lumped model of the saccadic premotor circuitry by reducing the inhibitory efficacy of omnipause neurons.

journal_name

Prog Brain Res

authors

Ramat S,Leigh RJ,Zee DS,Shaikh AG,Optican LM

doi

10.1016/S0079-6123(08)00616-X

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

123-30

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)00616-X

journal_volume

171

pub_type

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