The subiculum: cytoarchitectonically a simple structure, but hodologically complex.

Abstract:

:The subiculum gives rise to the majority of hippocampal projections to various telencephalic and diencephalic structures. Previously, these projections have been described using anterograde tracing with radioactively labeled amino acids. As part of an ongoing detailed analysis of the connectivity of the hippocampal region in the rat, we studied the projections of the subiculum by means of the recently introduced sensitive anterograde tracer Phaseolus vulgaris-leukoagglutinin (PHA-L) and double-labeling protocols with retrogradely transported fluorescent tracers. Within the subiculum, populations of neurons can be differentiated that each give rise to projections to a unique set of target structures. These populations of neurons, characterized according to common efferent connectivity, are differentially positioned along the transverse axis of the subiculum. Thus, subicular cells near the border with the CA1 field project to targets different from those reached by projections from subicular cells situated close to the border with the presubiculum. We further observed that major afferents of the subiculum, i.e. those arising from field CA1 and from the entorhinal cortex, are also organized along the transverse axis of the subiculum. We suggest that within the subiculum, that appears homogeneous with respect to both cytoarchitectonic and chemoarchitectonic characteristics, a differentiation can be made with respect to its major connections. Whether this differentiation takes the form of a "columnar organization" as known for the neocortex, or a "compartmentation" as shown for the striatum is not yet clear.

journal_name

Prog Brain Res

authors

Witter MP,Groenewegen HJ

doi

10.1016/s0079-6123(08)61240-6

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

47-58

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)61240-6

journal_volume

83

pub_type

杂志文章
  • How do motoric realities shape, and become shaped by, the way people evaluate and select potential courses of action? Toward a unitary framework of embodied decision making.

    abstract::Until recently, the constraints imposed on decision makers by the human physical condition - situated both as a physical agent and within physical space - have played only an incidental, if not entirely inconsequential, role in conceptualizations of human decision making. The act of deciding has been positioned as the...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)01316-8

    authors: DeCaro DA,Bar-Eli M,Conlin JA,Diederich A,Johnson JG,Plessner H

    更新日期:2009-01-01 00:00:00

  • Changing health behavior motivation from I-must to I-want.

    abstract::In the past, medicine was dominated by acute diseases. Since treatments were unknown to patients they followed their medical doctors´ directives-at least for the duration of the disease. Behavior was thus largely motivated by avoiding expected costs associated with alternative behaviors (I-must). The health challenges...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2016.06.013

    authors: Knecht S,Kenning P

    更新日期:2016-01-01 00:00:00

  • Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome.

    abstract::Early intervention and environmental optimization have been central to management of Down syndrome (DS) and much of current treatment is still focused in strategies that involve early education plans. This approach has provided significant improvements for Down syndrome but it is not providing a full success. The disc...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2019.11.001

    authors: Martínez Cué C,Dierssen M

    更新日期:2020-01-01 00:00:00

  • Genetics of chronic tinnitus.

    abstract::Susceptibility to chronic tinnitus is highly variable and of particular interest when it comes to defining strategies for prevention and treatment. While several rare monogenic disorders have been described that are associated with tinnitus, the genetic underpinnings of the more common forms of the syndrome are still ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66014-2

    authors: Sand PG,Langguth B,Kleinjung T,Eichhammer P

    更新日期:2007-01-01 00:00:00

  • Neuronal plasticity and thalamocortical sleep and waking oscillations.

    abstract::Throughout life, thalamocortical (TC) network alternates between activated states (wake or rapid eye movement sleep) and slow oscillatory state dominating slow-wave sleep. The patterns of neuronal firing are different during these distinct states. I propose that due to relatively regular firing, the activated states p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53839-0.00009-0

    authors: Timofeev I

    更新日期:2011-01-01 00:00:00

  • Dynamics of thalamo-cortical network oscillations and human perception.

    abstract::There is increasing evidence that human cognitive functions can be addressed from a robust neuroscience perspective. In particular, the distributed coherent electrical properties of central neuronal ensembles are considered to be a promising avenue of inquiry concerning global brain functions. The intrinsic oscillator...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)50010-4

    authors: Ribary U

    更新日期:2005-01-01 00:00:00

  • Aminopyridines for the treatment of cerebellar and ocular motor disorders.

    abstract::Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when physiological inhibitory cerebellar input, namely of the flocculus, to the vestibular nuclei is inhibited. The second most frequent form of acquired nystagmus is upbeat nystagmus (UBN). UBN is...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00676-6

    authors: Strupp M,Kalla R,Glasauer S,Wagner J,Hüfner K,Jahn K,Brandt T

    更新日期:2008-01-01 00:00:00

  • Morphogenesis timing of genetically programmed brain malformations in relation to epilepsy.

    abstract::Cerebral malformations are best understood as abnormal tissue morphogenesis in the context of disorders of ontogenesis. In neuroembryology, the timing of onset and duration of abnormal genetic expression and neurodevelopmental processes are primordial and must always be assessed, regardless whether the dysgenesis is p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63326-2.00010-7

    authors: Sarnat HB,Flores-Sarnat L

    更新日期:2014-01-01 00:00:00

  • Development of motor rhythms in zebrafish embryos.

    abstract::The nervous system can generate rhythms of various frequencies; on the low-frequency side, we have the circuits regulating circadian rhythms with a 24-h period, while on the high-frequency side we have the motor circuits that underlie flight in a hummingbird. Given the ubiquitous nature of rhythms, it is surprising th...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53613-6.00004-6

    authors: Saint-Amant L

    更新日期:2010-01-01 00:00:00

  • Expert music performance: cognitive, neural, and developmental bases.

    abstract::In this chapter, we explore what happens in the brain of an expert musician during performance. Understanding expert music performance is interesting to cognitive neuroscientists not only because it tests the limits of human memory and movement, but also because studying expert musicianship can help us understand skil...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2014.11.021

    authors: Brown RM,Zatorre RJ,Penhune VB

    更新日期:2015-01-01 00:00:00

  • On the moral import of the arts: The case of music.

    abstract::There has been a controversy on the moral import of music and art in general. On the one hand, the moralist view contends that there is some sort of link between art and morality, even if the way to specify this link may be highly diverse. It comprises most of the classical views of art, from Schiller's view of the ro...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2018.03.015

    authors: Gomila A,Christensen JF

    更新日期:2018-01-01 00:00:00

  • The development of topographically-aligned maps of visual and auditory space in the superior colliculus.

    abstract::The role of the superior colliculus in attending and orienting to sensory stimuli is facilitated by the presence within this midbrain nucleus of superimposed maps of different sensory modalities. We have studied the steps involved in the development of topographically-aligned maps of visual and auditory space in the f...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)63340-3

    authors: King AJ,Schnupp JW,Carlile S,Smith AL,Thompson ID

    更新日期:1996-01-01 00:00:00

  • Neural grafting in Parkinson's disease Problems and possibilities.

    abstract::Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits c...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(10)84014-2

    authors: Brundin P,Barker RA,Parmar M

    更新日期:2010-01-01 00:00:00

  • Chromatographically identified oxytocin in the human peripheral nervous system.

    abstract::Immunoreactive oxytocin (OXT) detected in extracts of human coeliac ganglia and nn. vagi was characterized by high-performance liquid chromatography (HPLC). HPLC/RIA examinations demonstrated that a major part of the immunoreactive material in both investigated areas co-eluted with a reference synthetic OXT, but in th...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)62321-3

    authors: Vecsernyés M,Jójárt I,Jójárt J,Laczi F

    更新日期:1992-01-01 00:00:00

  • Significance of proprioceptive mechanisms in the regulation of stance.

    abstract::Compensatory electromyographic (EMG) responses and several biomechanical parameters were studied following impulsive disturbance of the limbs during stance of human volunteers on a treadmill. Treadmill acceleration impulses were backwards or forwards directed, or their initial direction was reversed after 30 ms. Backw...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)62238-4

    authors: Dietz V,Horstmann GA,Berger W

    更新日期:1989-01-01 00:00:00

  • Physiological properties and afferent connections of the locus coeruleus and adjacent tegmental neurons involved in the generation of paradoxical sleep in the cat.

    abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63798-x

    authors: Sakai K

    更新日期:1991-01-01 00:00:00

  • Visuomotor transformations for eye-hand coordination.

    abstract::In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(02)40060-X

    authors: Henriques DY,Medendorp WP,Khan AZ,Crawford JD

    更新日期:2002-01-01 00:00:00

  • Functional synaptic plasticity in hypothalamic magnocellular neurons.

    abstract::The hypothalamic-neurohypophysial system undergoes dramatic morphological plasticity in response to physiological activation during parturition/lactation and dehydration, including somatic swelling, decreased glial coverage and increased synaptic innervation of the magnocellular neuroendocrine cells. Recent in-vitro e...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(02)39011-3

    authors: Tasker JG,Di S,Boudaba C

    更新日期:2002-01-01 00:00:00

  • Chapter 5 - Development of iron chelator-nanoparticle conjugates as potential therapeutic agents for Alzheimer disease.

    abstract::Oxidative stress is known to play a key role in the initiation and promotion of the neurodegeneration that characterizes the pathogenesis of Alzheimer disease (AD). An accumulation of redox active transition metals, including iron and copper, is likely a major generator of reactive oxidative species and other free rad...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)80005-2

    authors: Liu G,Men P,Perry G,Smith MA

    更新日期:2009-01-01 00:00:00

  • Nonvisual influences on visual-information processing in the superior colliculus.

    abstract::Although visually responsive neurons predominate in the deep layers of the superior colliculus (SC), the majority of them also receive sensory inputs from nonvisual sources (i.e. auditory and/or somatosensory). Most of these 'multisensory' neurons are able to synthesize their cross-modal inputs and, as a consequence, ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(01)34011-6

    authors: Stein BE,Jiang W,Wallace MT,Stanford TR

    更新日期:2001-01-01 00:00:00

  • Prodromal PD: A new nosological entity.

    abstract::Recent years have brought a rapid growth in knowledge of the prodromal phase of Parkinson's disease (PD). It is now clear that the clinical phase of PD is preceded by a phase of progressing neurodegeneration lasting many years. This involves not only central nervous system structures outside the substantia nigra and n...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2020.01.003

    authors: Schaeffer E,Postuma RB,Berg D

    更新日期:2020-01-01 00:00:00

  • Brainstem neural circuits for fixation and generation of saccadic eye movements.

    abstract::We review neural connections of the superior colliculus (SC) and brainstem saccade-related neurons in relation to saccade generation mechanism. The caudal and rostral SC play a role in saccade generation and visual fixation, respectively. This functional differentiation suggests that different connections should exist...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2019.04.007

    authors: Shinoda Y,Takahashi M,Sugiuchi Y

    更新日期:2019-01-01 00:00:00

  • Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord.

    abstract::Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending (sensory) pathways and descending (motor) nerve pathways without the perspective of complete functional recovery. Future spinal cord repair strategies should comprise a multi-factorial approach addressing several issues, includin...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(03)46029-9

    authors: Hendriks WT,Ruitenberg MJ,Blits B,Boer GJ,Verhaagen J

    更新日期:2004-01-01 00:00:00

  • Involvement of astrocytes in neurovascular communication.

    abstract::The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional role...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2016.02.001

    authors: Nuriya M,Hirase H

    更新日期:2016-01-01 00:00:00

  • Human brain evolution writ large and small.

    abstract::Human evolution was marked by an extraordinary increase in total brain size relative to body size. While it is certain that increased encephalization is an important factor contributing to the origin of our species-specific cognitive abilities, it is difficult to disentangle which aspects of human neural structure and...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53860-4.00011-8

    authors: Sherwood CC,Bauernfeind AL,Bianchi S,Raghanti MA,Hof PR

    更新日期:2012-01-01 00:00:00

  • Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?

    abstract::The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While multiple growth factors and adipokines are identified in atherosclerotic lesions, as well as neurotrophins implicated in both ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(03)46018-4

    authors: Chaldakov GN,Fiore M,Stankulov IS,Manni L,Hristova MG,Antonelli A,Ghenev PI,Aloe L

    更新日期:2004-01-01 00:00:00

  • Sex and gender differences in pain and analgesia.

    abstract::It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference....

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53630-3.00009-9

    authors: Mogil JS,Bailey AL

    更新日期:2010-01-01 00:00:00

  • Microsaccades: A microcosm for research on oculomotor control, attention, and visual perception.

    abstract::Miniature eye movements occur involuntarily during visual fixation. The most prominent contribution to these fixational eye movements is generated by microsaccades, which are rapid small-amplitude saccades with a rate of about one per second. Recent work demonstrates that microsaccades are optimized to counteract perc...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)54009-9

    authors: Engbert R

    更新日期:2006-01-01 00:00:00

  • The effects of surgery and anesthesia on memory and cognition.

    abstract::This chapter describes current findings from the research into postoperative cognitive dysfunction (POCD) following cardiac and non-cardiac surgery in older adults. The evidence suggests that a significant proportion of patients show POCD in the early weeks following surgery and anesthesia. Specific domains of cogniti...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)00026-X

    authors: Caza N,Taha R,Qi Y,Blaise G

    更新日期:2008-01-01 00:00:00

  • Can athletes benefit from difficulty? A systematic review of growth following adversity in competitive sport.

    abstract::Research points to the notion that athletes have the potential to benefit from difficulty. This phenomenon-otherwise known as growth following adversity-has attracted increasing attention from sport psychology scholars. In this paper, we systematically review and synthesize the findings of studies in this area to bett...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2017.06.002

    authors: Howells K,Sarkar M,Fletcher D

    更新日期:2017-01-01 00:00:00