Abstract：
:The subiculum gives rise to the majority of hippocampal projections to various telencephalic and diencephalic structures. Previously, these projections have been described using anterograde tracing with radioactively labeled amino acids. As part of an ongoing detailed analysis of the connectivity of the hippocampal region in the rat, we studied the projections of the subiculum by means of the recently introduced sensitive anterograde tracer Phaseolus vulgaris-leukoagglutinin (PHA-L) and double-labeling protocols with retrogradely transported fluorescent tracers. Within the subiculum, populations of neurons can be differentiated that each give rise to projections to a unique set of target structures. These populations of neurons, characterized according to common efferent connectivity, are differentially positioned along the transverse axis of the subiculum. Thus, subicular cells near the border with the CA1 field project to targets different from those reached by projections from subicular cells situated close to the border with the presubiculum. We further observed that major afferents of the subiculum, i.e. those arising from field CA1 and from the entorhinal cortex, are also organized along the transverse axis of the subiculum. We suggest that within the subiculum, that appears homogeneous with respect to both cytoarchitectonic and chemoarchitectonic characteristics, a differentiation can be made with respect to its major connections. Whether this differentiation takes the form of a "columnar organization" as known for the neocortex, or a "compartmentation" as shown for the striatum is not yet clear.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Witter MP,Groenewegen HJdoi
10.1016/s0079-6123(08)61240-6subject
Has Abstractpub_date
1990-01-01 00:00:00pages
47-58eissn
0079-6123issn
1875-7855pii
S0079-6123(08)61240-6journal_volume
83pub_type
杂志文章abstract：:An unresolved issue in visual motion perception is how distinct are the processes underlying 'first-order' and 'second-order' motion. The former is defined by spatio-temporal variations of luminance and the latter by spatio-temporal variations in other image attributes such as contrast or depth, for example. Using neu...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)14414-7
更新日期：2004-01-01 00:00:00
abstract：:Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei (SCN) co-ordinates these metabolic cycles. Circadian timing is based upon a transcriptional/post-translational negative feedback loop invol...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)53015-8
更新日期：2006-01-01 00:00:00
abstract：:Sub-lethal exposure to practically any harmful stimulus has been shown to induce consequent protection against more severe stress. This preconditioning (PC) effect may be achieved by exposure to different stressors, indicating that the induction of tolerance involves activation of common protective pathways. Chronic e...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)61025-X
更新日期：2007-01-01 00:00:00
abstract：:While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)43025-2
更新日期：2004-01-01 00:00:00
abstract：:The complex migrations of neurons born in the dorsal neural tube of the isthmic and rhombomere l (rl) domains complicate the delineation of the cerebellar primordium. We show that Purkinje cells (P) are likely generated over a wide territory before gathering in the future cerebellar primordium under the developing ext...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(04)48003-0
更新日期：2005-01-01 00:00:00
abstract：:The organization of key molecules at glutamatergic synapses in the rat cerebellar cortex as analyzed by high resolution immunocytochemical techniques using gold particles as markers. The distinct compartmentation of glutamate and glutamine was consistent with biochemical data indicating an active role of glia in the r...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)63360-9
更新日期：1997-01-01 00:00:00
abstract：:High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related di...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)61561-7
更新日期：1998-01-01 00:00:00
abstract：:Essential infantile esotropia (EIE) is often attributed to a primary disturbance within the visual cortex based upon the findings of monocular horizontal optokinetic asymmetry and correlative horizontal motion detection asymmetry. However, these physiologic aberrations conform to what would be observed if the visual c...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2019.04.001
更新日期：2019-01-01 00:00:00
abstract：:Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(01)30018-3
更新日期：2001-01-01 00:00:00
abstract：:The study of chimeric retinas has yielded insight on the early development of retina. The close match in chimerism ratios between right and left retinas is significant and supports the idea that both retinas originate from a common population of progenitors. We are able to estimate numbers of progenitor cells that con...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)62528-5
更新日期：1996-01-01 00:00:00
abstract：:Concerted efforts are realizing cell-based therapy for Parkinson's disease (PD). In this chapter, I describe efforts at the Center for iPS Cell Research and Application (CiRA), Kyoto University. These efforts use induced pluripotent stem cells (iPSCs) as donor cells. The iPSCs were established as human leukocyte antig...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:It was generally accepted by the early 1960s that proton beam radiosurgery was too complex and impractical. The need was seen for a new machine. The beam design had to be as good as a proton beam. It was also decided that a static design was preferable even if the evolution of that notion is no longer clear. Complex c...
journal_title：Progress in brain research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/B978-0-444-63520-4.00007-7
更新日期：2014-01-01 00:00:00
abstract：:One of the more interesting and complex phenomena involving neurohypophysial hormones is the milk ejection reflex and the events surrounding it. Accordingly, many investigations over the years have taken up the challenge of elucidating its myriad aspects. Much has been learned from in vivo preparations about the seque...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(08)00414-7
更新日期：2008-01-01 00:00:00
abstract：:In order to study cerebral activity related to preparation and execution of movement, evoked and induced brain electrical activities were compared to each other and to fMRI results in voluntary self-paced movements. Also, the event-related desynchronization and synchronization (ERD/ERS) were studied in complex movemen...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(06)59021-1
更新日期：2006-01-01 00:00:00
abstract：:We review neural connections of the superior colliculus (SC) and brainstem saccade-related neurons in relation to saccade generation mechanism. The caudal and rostral SC play a role in saccade generation and visual fixation, respectively. This functional differentiation suggests that different connections should exist...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2019.04.007
更新日期：2019-01-01 00:00:00
abstract：:Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00666-3
更新日期：2008-01-01 00:00:00
abstract：:The description of a biological system using a mathematical model is the most effective means to specify the functioning of a quantitative hypothesis, providing at the same time the ability to make predictions that can be further tested experimentally. The Vestibulo-Ocular Reflex (VOR), and more generally the ocular m...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2019.04.030
更新日期：2019-01-01 00:00:00
abstract：:Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradua...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-62604-2.00018-6
更新日期：2013-01-01 00:00:00
abstract：:Activated microglia release a number of substances, the specific cocktail released depending on the stimulus. Many of the substances released by microglia also serve to activate them, suggesting the presence of a number of autocrine/paracrine loops. Because of the low density of microglia present in the normal brain, ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(01)32103-9
更新日期：2001-01-01 00:00:00
abstract：:Rebound nystagmus, a common cerebellar sign, is a transient nystagmus that appears on returning to straight-ahead gaze after prolonged eccentric gaze. The slow phases of rebound nystagmus are in the direction of prior eccentric gaze. After eccentric gaze, healthy subjects also show rebound nystagmus when fixation is r...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2019.04.040
更新日期：2019-01-01 00:00:00
abstract：:A dense serotonin (5-HT)-containing projection to the superficial layers of the superior colliculus (SC) has been demonstrated in diverse mammalian species, but how 5-HT may affect visual signals within these laminae is largely unknown. This study undertook to investigate the distribution of 2 types of 5-HT receptors ...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63320-8
更新日期：1996-01-01 00:00:00
abstract：:The target article describes an interesting study, which provides some challenging findings regarding athletes' pathway to excellence. The suggested links between critical life events, need for success, personal characteristics, and eventual performance level make sense from a psychodynamic perspective. This commentar...
journal_title：Progress in brain research
pub_type： 评论,杂志文章
doi：10.1016/bs.pbr.2017.02.004
更新日期：2017-01-01 00:00:00
abstract：:The success of axon regeneration in the adult mammalian brain depends on the presence of growth-permissive environmental conditions as well as on specific properties of the affected neurons. To investigate the relative contribution of extrinsic cues and intrinsic determinants to reparative processes we have investigat...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)63370-1
更新日期：1997-01-01 00:00:00
abstract：:The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective o...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-53815-4.00011-X
更新日期：2011-01-01 00:00:00
abstract：:1. Alzheimer's disease is a multifactorial disease in which age and APOE-epsilon 4 are important risk factors. Various mutations and even viral infections such as herpes simplex (Itzhaki et al., 1997) may play an additional role. 2. The neuropathological hallmarks of Alzheimer's disease (AD), i.e. amorphous plaques, n...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)64027-3
更新日期：1998-01-01 00:00:00
abstract：:Primates are endowed with a brain about twice the size that of a mammal with the same body size, and humans have the largest brain relative to body size of all animals. This increase in brain size may be related to the acquisition of higher cognitive skills that permitted more complex social interactions, the evolutio...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53860-4.00001-5
更新日期：2012-01-01 00:00:00
abstract：:The dorsal striatum (caudate putamen) contains two types of GABAergic medium spiny neurons (MSNs) that are distinguished by the expression of either the opioid peptide, enkephalin, or the opioid peptide, dynorphin, as well as the tachykinin substance P. Pharmacological studies suggest that these peptides modulate loca...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)60016-2
更新日期：2007-01-01 00:00:00
abstract：:The main topic of this overview is an analysis of the concepts of phase and synchrony, as used in neurophysiology, in their various meanings. A number of notions related to the concepts of phase and synchrony, which are incorporated in contemporary neurophysiology, particularly in the domain of neuro-cognitive physiol...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)59001-6
更新日期：2006-01-01 00:00:00
abstract：:This overview highlights the presentations made by several authors, with sidelights commentaries on the topics covered in this session. The Neurotropic hypothesis, formulated by Cajal more than one century ago, has been one of the fundamental tenets of modern Neuroscience. Research work is unveiling highly complex mol...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(02)36003-5
更新日期：2002-01-01 00:00:00
abstract：:Primates are able to recognize a particular object despite major differences in the retinal images of the object. Inferior temporal cortex is suggested to be involved in this invariant object recognition. Neurons of this cortex show shape selectivity and it has been shown that this shape selectivity is relatively inva...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63330-0
更新日期：1996-01-01 00:00:00
