Vasopressin binding sites in the central nervous system: distribution and regulation.

Abstract:

:High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related differences of the VP receptor distribution have been revealed. Some evidence has also been provided that mechanisms of receptor regulation may vary among species. In the rat, the expression of VP binding sites in some motor nuclei shows remarkable plasticity, in particular up-regulation after axotomy. These data suggest that VP may, in addition to affecting motoneuronal excitability, act as a trophic factor onto motoneurones.

journal_name

Prog Brain Res

authors

Tribollet E,Arsenijevic Y,Barberis C

doi

10.1016/s0079-6123(08)61561-7

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

45-55

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)61561-7

journal_volume

119

pub_type

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