Mechanisms of neuronal plasticity as analyzed at the single cell level.

Abstract:

:This chapter has highlighted how correlates of neuronal plasticity such as electrophysiological responsiveness and changes in gene expression may be examined in defined CNS regions as well as in single cells. The ability to simultaneously measure the mRNA levels for hundreds of different genes, to clone novel genes, and to characterize the physiology and morphology of the cell promises to provide insight into molecular mechanisms of plasticity. The importance of understanding how one gene product changes relative to another (coordinated changes) as well as subcellular distribution of mRNAs cannot be overstated. It is only through an analysis of both the molecular and cellular processes associated with plasticity that a thorough understanding of the mechanisms of neuronal plasticity can be gained.

journal_name

Prog Brain Res

authors

Eberwine J,Cao Y,Nair S,Miyashiro K,Mackler S,Finnell R,Surmeier J,Dichter M

doi

10.1016/s0079-6123(08)63289-6

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

117-26

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)63289-6

journal_volume

105

pub_type

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