Abstract:
:This chapter has highlighted how correlates of neuronal plasticity such as electrophysiological responsiveness and changes in gene expression may be examined in defined CNS regions as well as in single cells. The ability to simultaneously measure the mRNA levels for hundreds of different genes, to clone novel genes, and to characterize the physiology and morphology of the cell promises to provide insight into molecular mechanisms of plasticity. The importance of understanding how one gene product changes relative to another (coordinated changes) as well as subcellular distribution of mRNAs cannot be overstated. It is only through an analysis of both the molecular and cellular processes associated with plasticity that a thorough understanding of the mechanisms of neuronal plasticity can be gained.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Eberwine J,Cao Y,Nair S,Miyashiro K,Mackler S,Finnell R,Surmeier J,Dichter Mdoi
10.1016/s0079-6123(08)63289-6subject
Has Abstractpub_date
1995-01-01 00:00:00pages
117-26eissn
0079-6123issn
1875-7855pii
S0079-6123(08)63289-6journal_volume
105pub_type
杂志文章,评审abstract::The success of axon regeneration in the adult mammalian brain depends on the presence of growth-permissive environmental conditions as well as on specific properties of the affected neurons. To investigate the relative contribution of extrinsic cues and intrinsic determinants to reparative processes we have investigat...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63370-1
更新日期:1997-01-01 00:00:00
abstract::In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)40060-X
更新日期:2002-01-01 00:00:00
abstract::Why do complex-partial seizures in temporal lobe epilepsy (TLE) cause a loss of consciousness? Abnormal function of the medial temporal lobe is expected to cause memory loss, but it is unclear why profoundly impaired consciousness is so common in temporal lobe seizures. Recent exciting advances in behavioral, electrop...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17711-7
更新日期:2009-01-01 00:00:00
abstract::The rat subcommissural organ (SCO), which forms the roof of the third ventricle is an adequate model to study certain mechanisms of neuron-glia interactions in vivo. The ependymocytes, the main component of the SCO, have a glial origin. They possess particular phenotypic characteristics: they accumulate [3H]GABA by a ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62352-3
更新日期:1992-01-01 00:00:00
abstract::Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology. BDNF in particular has ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)63022-2
更新日期:2007-01-01 00:00:00
abstract::Primates are endowed with a brain about twice the size that of a mammal with the same body size, and humans have the largest brain relative to body size of all animals. This increase in brain size may be related to the acquisition of higher cognitive skills that permitted more complex social interactions, the evolutio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53860-4.00001-5
更新日期:2012-01-01 00:00:00
abstract::In vivo functional imaging has provided objective evidence for the integration and function of nigral grafts in the brains of patients with Parkinson's disease. Clinical trials with the use of positron emission tomography have shown that transplants of human dopamine-rich fetal ventral mesencephalic tissue can survive...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-59575-1.00009-0
更新日期:2012-01-01 00:00:00
abstract::The hypothalamic-neurohypophysial system undergoes dramatic morphological plasticity in response to physiological activation during parturition/lactation and dehydration, including somatic swelling, decreased glial coverage and increased synaptic innervation of the magnocellular neuroendocrine cells. Recent in-vitro e...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(02)39011-3
更新日期:2002-01-01 00:00:00
abstract::Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00666-3
更新日期:2008-01-01 00:00:00
abstract::Selective attention is an important aspect of brain function that we need in coping with the immense and constant barrage of sensory information. One model of attention (Feature Integration Theory) that suggests an early selection of spatial locations of objects via an attentional spotlight would also solve the 'bindi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)34020-7
更新日期:2001-01-01 00:00:00
abstract::In order to study cerebral activity related to preparation and execution of movement, evoked and induced brain electrical activities were compared to each other and to fMRI results in voluntary self-paced movements. Also, the event-related desynchronization and synchronization (ERD/ERS) were studied in complex movemen...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(06)59021-1
更新日期:2006-01-01 00:00:00
abstract::The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While multiple growth factors and adipokines are identified in atherosclerotic lesions, as well as neurotrophins implicated in both ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)46018-4
更新日期:2004-01-01 00:00:00
abstract::The febrile reaction is an integrated endocrine, autonomic and behavioral response, coordinated by the hypothalamus, that includes certain components of the stress response, such as elevated corticosteroid secretion. It is produced by the actions of circulating cytokines, such as interleukin-1 (IL-1) and tumor necrosi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)64587-2
更新日期:1992-01-01 00:00:00
abstract::Immunoreactive oxytocin (OXT) detected in extracts of human coeliac ganglia and nn. vagi was characterized by high-performance liquid chromatography (HPLC). HPLC/RIA examinations demonstrated that a major part of the immunoreactive material in both investigated areas co-eluted with a reference synthetic OXT, but in th...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62321-3
更新日期:1992-01-01 00:00:00
abstract::In this chapter, the distribution of Hsp70 in brain cell types following whole body hyperthermia is reviewed. The prevalence of Hsp70 expression in oligodendrocytes, microglia, and vascular cells in this type of stress contrasts with scarcity of Hsp70 induction in astrocytes and most neurons of the hyperthermic brain....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)62020-7
更新日期:2007-01-01 00:00:00
abstract::Spinal cord injury (SCI) typically damages the long axonal tracts of the spinal cord which results in permanent disability. However, regeneration of the injured spinal cord is approaching reality according to the advances in stem cell biology. Cell transplantation therapy holds potential to lead to recovery following ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2016.12.007
更新日期:2017-01-01 00:00:00
abstract::When an object partially or completely disappears behind an occluding surface, a representation of that object persists. For example, fragments of no longer visible objects can serve as an input into mid-level constructive visual processes, interacting and integrating with currently visible portions to form perceptual...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.07.010
更新日期:2017-01-01 00:00:00
abstract::The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective o...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53815-4.00011-X
更新日期:2011-01-01 00:00:00
abstract::One of the more interesting and complex phenomena involving neurohypophysial hormones is the milk ejection reflex and the events surrounding it. Accordingly, many investigations over the years have taken up the challenge of elucidating its myriad aspects. Much has been learned from in vivo preparations about the seque...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)00414-7
更新日期:2008-01-01 00:00:00
abstract::It has been known for decades that females are more susceptible than men to inflammatory autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis. In addition, female patients with these diseases experience clinical improvements during pregnancy with a temporary "rebound" exacerbatio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17516-7
更新日期:2009-01-01 00:00:00
abstract::Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits c...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)84014-2
更新日期:2010-01-01 00:00:00
abstract::In the last few years, theorists have argued that culture can shape processes of basic visual perception. This work has primarily focused on cultural influences in nonsocial domains, such as cross-cultural differences in seeing and attending to focal stimuli versus backgrounds. Recently, researchers have begun to exam...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17813-5
更新日期:2009-01-01 00:00:00
abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(09)01306-5
更新日期:2009-01-01 00:00:00
abstract::Neurons in the midbrain superior colliculus (SC) have the ability to integrate information from different senses to profoundly increase their sensitivity to external events. This not only enhances an organism's ability to detect and localize these events, but to program appropriate motor responses to them. The surviva...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53752-2.00007-2
更新日期:2011-01-01 00:00:00
abstract::We developed a theoretical framework for studying coordination strategies in standing posture. The framework consists of a musculoskeletal model of the human lower extremity in the sagittal plane and a technique to visualize, geometrically, how constraints internal and external to the body affect movement. The set of ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62294-3
更新日期:1993-01-01 00:00:00
abstract::Mechanism is at the heart of understanding, and this chapter addresses underlying brain mechanisms and pathways of cognition and the impact of sleep on these processes, especially those serving learning and memory. This chapter reviews the current understanding of the relationship between sleep/waking states and cogni...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53702-7.00001-4
更新日期:2010-01-01 00:00:00
abstract::Individual differences in cognitive functioning during extended work hours and shift work are of considerable magnitude, and observed both in the laboratory and in the workplace. These individual differences have a biological basis in trait-like, differential vulnerability to fatigue from sleep loss and circadian misa...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53817-8.00009-8
更新日期:2011-01-01 00:00:00
abstract::Children with epilepsy are known to have high rates of mental health problems. The role of seizures in the development of these problems is not known primarily because of difficulties in separating the effects of seizures from the three other potential causal factors: (a) poor child and family response to the conditio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)35039-8
更新日期:2002-01-01 00:00:00
abstract::Hand preference is a sensorimotor skill whose development both reflects and promotes the development of hemispheric lateralization for manual and cognitive functions. Extensive comparative, crosscultural, and paleoanthropological evidence demonstrates the prevalence of limb lateralized preferences across vertebrate sp...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2018.06.007
更新日期:2018-01-01 00:00:00
abstract::The main topic of this overview is an analysis of the concepts of phase and synchrony, as used in neurophysiology, in their various meanings. A number of notions related to the concepts of phase and synchrony, which are incorporated in contemporary neurophysiology, particularly in the domain of neuro-cognitive physiol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)59001-6
更新日期:2006-01-01 00:00:00