Multimodal, longitudinal assessment of intracortical microstimulation.

Abstract:

:The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective of this research is to identify the optimal parameters for a chronically implanted microstimulation device. In particular, the work presented here focuses on the effects of repeated stimulation and the reactive tissue response on the efficacy of stimulation-driven behavior. To this end, psychophysical experiments were performed using multichannel cortical implants in the auditory cortex of rats. Further, we investigated the effect of the device-tissue interfacial quality on the psychophysical threshold. Here, we report the effects of cortical depth, days postimplant on the psychophysical threshold of auditory cortical microstimulation, along with correlated impedance spectral changes and post vivo histology. We expect that these data will further enable neuroprosthetic development.

journal_name

Prog Brain Res

authors

Koivuniemi A,Wilks SJ,Woolley AJ,Otto KJ

doi

10.1016/B978-0-444-53815-4.00011-X

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

131-44

eissn

0079-6123

issn

1875-7855

pii

B978-0-444-53815-4.00011-X

journal_volume

194

pub_type

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