Abstract:
:The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective of this research is to identify the optimal parameters for a chronically implanted microstimulation device. In particular, the work presented here focuses on the effects of repeated stimulation and the reactive tissue response on the efficacy of stimulation-driven behavior. To this end, psychophysical experiments were performed using multichannel cortical implants in the auditory cortex of rats. Further, we investigated the effect of the device-tissue interfacial quality on the psychophysical threshold. Here, we report the effects of cortical depth, days postimplant on the psychophysical threshold of auditory cortical microstimulation, along with correlated impedance spectral changes and post vivo histology. We expect that these data will further enable neuroprosthetic development.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Koivuniemi A,Wilks SJ,Woolley AJ,Otto KJdoi
10.1016/B978-0-444-53815-4.00011-Xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
131-44eissn
0079-6123issn
1875-7855pii
B978-0-444-53815-4.00011-Xjournal_volume
194pub_type
杂志文章abstract::This is a brief review of event-related brain potentials (ERPs) as indices of cortical information processing in conditions in which conscious perception of stimuli is supposed to be absent: sleep, coma, vegetative state, general anesthesia, neglect as well as presentation of subliminal or masked stimuli. Exogenous ER...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
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更新日期:2004-01-01 00:00:00
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journal_title:Progress in brain research
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doi:10.1016/S0079-6123(10)82002-3
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journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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