Molecular genetic approaches to puerperal psychosis.

Abstract:

:Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth follows approximately one in 1000 deliveries. The evidence of clinical, outcome and genetic studies supports the hypothesis that the majority of puerperal psychotic episodes are manifestations of an affective disorder diathesis with a puerperal trigger. Furthermore the available evidence supports the hypothesis that genes are involved in susceptibility to both diathesis and trigger. For complex genetic disorders such as affective illness there are marked benefits in focussing on a homogeneous subtype which allows a subset of hypotheses to be tested. Molecular genetic studies of puerperal psychosis provide an excellent example of this strategy, allowing a hierarchy of hypotheses concerning the involvement of neurosteroid pathways in pathophysiology to be tested. Puerperal psychosis results in considerable suffering to a woman and her family. Elucidating the pathophysiological basis of this disorder will lead to better prevention and treatment and, it is anticipated, inform research on affective disorders more generally.

journal_name

Prog Brain Res

authors

Jones I,Lendon C,Coyle N,Robertson E,Brockington I,Craddock N

doi

10.1016/s0079-6123(01)33024-8

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

321-31

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(01)33024-8

journal_volume

133

pub_type

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