Genetic mouse models of Parkinson's disease The state of the art.

abstract：:Alzheimer's disease (AD), the most common type of adult-onset dementia, is characterized by a variety of brain abnormalities, including degeneration of certain populations of nerve cells, alterations in the neuronal cytoskeleton, and the abnormal deposition of amyloid within brain parenchyma. Pathogenetic processes th...

journal_title：Progress in brain research

authors： Price DL,Koo EH,Sisodia SS,Martin LJ,Koliatsos VE,Muma NA,Walker LC,Cork LC

更新日期：1990-01-01 00:00:00

abstract：:The visual system is tied to the retina. Because the eyes move in the orbit, and the head moves on the body, accurate location of an object in extrapersonal space cannot simply result from a visual signal. Instead, the retinal signal must be combined with an estimate of where the eyes are in the orbit, and where the h...

journal_title：Progress in brain research

authors： Zhang M,Wang X,Goldberg ME

更新日期：2008-01-01 00:00:00

abstract：:Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are c...

journal_title：Progress in brain research

authors： Mackey S,Kan KJ,Chaarani B,Alia-Klein N,Batalla A,Brooks S,Cousijn J,Dagher A,de Ruiter M,Desrivieres S,Feldstein Ewing SW,Goldstein RZ,Goudriaan AE,Heitzeg MM,Hutchison K,Li CS,London ED,Lorenzetti V,Luijten M,Mart

更新日期：2016-01-01 00:00:00

abstract：:Neuronal activity increases synthesis of brain-derived neurotrophic factor (BDNF) mRNA in vivo and in vitro. We have investigated the pathways through which neuronal activity stimulated by kainic acid regulates BDNF mRNA levels in cultured hippocampal neurons and transgenic mice. Kainic acid induced the transcription ...

journal_title：Progress in brain research

authors： Castrén E,Berninger B,Leingärtner A,Lindholm D

更新日期：1998-01-01 00:00:00

abstract：:Individual differences in cognitive functioning during extended work hours and shift work are of considerable magnitude, and observed both in the laboratory and in the workplace. These individual differences have a biological basis in trait-like, differential vulnerability to fatigue from sleep loss and circadian misa...

journal_title：Progress in brain research

authors： Van Dongen HP,Caldwell JA Jr,Caldwell JL

更新日期：2011-01-01 00:00:00

abstract：:High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related di...

journal_title：Progress in brain research

authors： Tribollet E,Arsenijevic Y,Barberis C

更新日期：1998-01-01 00:00:00

abstract：:It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference....

journal_title：Progress in brain research

authors： Mogil JS,Bailey AL

更新日期：2010-01-01 00:00:00

abstract：:An unresolved issue in visual motion perception is how distinct are the processes underlying 'first-order' and 'second-order' motion. The former is defined by spatio-temporal variations of luminance and the latter by spatio-temporal variations in other image attributes such as contrast or depth, for example. Using neu...

journal_title：Progress in brain research

authors： Vaina LM,Soloviev S

更新日期：2004-01-01 00:00:00

abstract：:It has been tacitly assumed that a long descending motor tract axon consists of a private line connecting the cell of origin to a single muscle, as a motoneuron innervates a single muscle. However, this notion of a long descending motor tract referred to as a private line is no longer tenable, since recent studies hav...

journal_title：Progress in brain research

authors： Shinoda Y,Sugiuchi Y,Izawa Y,Hata Y

更新日期：2006-01-01 00:00:00

abstract：:Otoacoustic emissions can be used to study cochlear function in an objective, non-invasive and rapid manner. These and other desirable features of emissions have inspired a significant amount of investigation into the practicalities of utilizing evoked emissions as clinical tests of hearing. Variables which affect the...

journal_title：Progress in brain research

authors： Lonsbury-Martin BL,Whitehead ML,Martin GK

更新日期：1993-01-01 00:00:00

abstract：:It has been known for decades that females are more susceptible than men to inflammatory autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis. In addition, female patients with these diseases experience clinical improvements during pregnancy with a temporary "rebound" exacerbatio...

journal_title：Progress in brain research

authors： Gold SM,Voskuhl RR

更新日期：2009-01-01 00:00:00

abstract：:Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...

journal_title：Progress in brain research

authors： Fu P,Chang R,O'Beirne K,King WM

更新日期：2008-01-01 00:00:00

abstract：:This is a brief review of event-related brain potentials (ERPs) as indices of cortical information processing in conditions in which conscious perception of stimuli is supposed to be absent: sleep, coma, vegetative state, general anesthesia, neglect as well as presentation of subliminal or masked stimuli. Exogenous ER...

journal_title：Progress in brain research

authors： Kotchoubey B

更新日期：2005-01-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors have been implicated as a mediator of neuronal injury associated with many neurological disorders including ischemia, epilepsy, brain trauma, dementia and neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease. To this, non-selective NMDA receptor ant...

journal_title：Progress in brain research

authors： Gardoni F,Ghiglieri V,Di Luca M,Calabresi P

更新日期：2010-01-01 00:00:00

abstract：:The nervous system can generate rhythms of various frequencies; on the low-frequency side, we have the circuits regulating circadian rhythms with a 24-h period, while on the high-frequency side we have the motor circuits that underlie flight in a hummingbird. Given the ubiquitous nature of rhythms, it is surprising th...

journal_title：Progress in brain research

authors： Saint-Amant L

更新日期：2010-01-01 00:00:00

abstract：:Miniature eye movements occur involuntarily during visual fixation. The most prominent contribution to these fixational eye movements is generated by microsaccades, which are rapid small-amplitude saccades with a rate of about one per second. Recent work demonstrates that microsaccades are optimized to counteract perc...

journal_title：Progress in brain research

authors： Engbert R

更新日期：2006-01-01 00:00:00

abstract：:The ability to silence, in a temporally precise fashion, the electrical activity of specific neurons embedded within intact brain tissue, is important for understanding the role that those neurons play in behaviors, brain disorders, and neural computations. "Optogenetic" silencers, genetically encoded molecules that, ...

journal_title：Progress in brain research

authors： Chow BY,Han X,Boyden ES

更新日期：2012-01-01 00:00:00

abstract：:In this chapter, we explore what happens in the brain of an expert musician during performance. Understanding expert music performance is interesting to cognitive neuroscientists not only because it tests the limits of human memory and movement, but also because studying expert musicianship can help us understand skil...

journal_title：Progress in brain research

authors： Brown RM,Zatorre RJ,Penhune VB

更新日期：2015-01-01 00:00:00

abstract：:Rebound nystagmus, a common cerebellar sign, is a transient nystagmus that appears on returning to straight-ahead gaze after prolonged eccentric gaze. The slow phases of rebound nystagmus are in the direction of prior eccentric gaze. After eccentric gaze, healthy subjects also show rebound nystagmus when fixation is r...

journal_title：Progress in brain research

authors： Otero-Millan J,Colpak AI,Kheradmand A,Zee DS

更新日期：2019-01-01 00:00:00

abstract：:Regaining any locomotor function after spinal cord injury is not only of immediate importance for affected patients but also for clinical research as it allows to investigate mechanisms underlying motor impairment and locomotor recovery. Clinical scores inform on functional outcomes that are clinically meaningful to v...

journal_title：Progress in brain research

authors： Awai L,Curt A

更新日期：2015-01-01 00:00:00

abstract：:Recent accounts of tinnitus development and maintenance assign an important role to central mechanisms. Residual inhibition is a frequent phenomenon in individuals with tinnitus, and refers to the fact that tinnitus can temporarily be reduced by presenting sounds or noises that inhibit tinnitus for a limited time even...

journal_title：Progress in brain research

authors： Struve M,Diesch E,Flor H

更新日期：2007-01-01 00:00:00

abstract：:The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...

journal_title：Progress in brain research

authors： Harris-Warrick RM

更新日期：2010-01-01 00:00:00

abstract：:Several studies provided evidence for neuroendocrine dysregulations in adults with a history of child sexual abuse. This review focuses on neuroendocrine studies in sexually abused children and adolescents, dating from January 1, 1990 to January 1, 2007 and obtained from a systematic Medline Indexed literature search ...

journal_title：Progress in brain research

authors： Bicanic IA,Meijer M,Sinnema G,van de Putte EM,Olff M

更新日期：2008-01-01 00:00:00

abstract：:Two cortical areas that crucially contribute to the generation and maintenance of smooth pursuit eye movements (SPEM) are the medial superior temporal area (MST) and the pursuit area of the frontal eye fields (FEF). They both project to the brainstem premotor structures via different parallel pathways. A special prope...

journal_title：Progress in brain research

authors： Nuding U,Ono S,Mustari MJ,Büttner U,Glasauer S

更新日期：2008-01-01 00:00:00

abstract：:Deficits in motivation are at the core of many neuropsychiatric disorders, including major depressive disorder (MDD). Research in MDD has been heavily focused on anhedonia and depression or negative/positive symptoms of depression, with less research attention focused on the dysregulation of motivational processes. Op...

journal_title：Progress in brain research

authors： Callaghan CK,Rouine J,O'Mara SM

更新日期：2018-01-01 00:00:00

abstract：:This contribution reviewed the available evidence on the domain-specific and domain-general neurocognitive determinants of children's arithmetic development, other than nonsymbolic numerical magnitude processing, which might have been overemphasized as a core factor of individual differences in mathematics and dyscalc...

journal_title：Progress in brain research

authors： Vanbinst K,De Smedt B

更新日期：2016-01-01 00:00:00

abstract：:Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth follows approximately one in 1000 deliveries. The evidence of clinical, outcome and genetic studies supports the hypothesis that the majority of puerperal psychotic episodes are manifestations of an affective disorder diathesis with a pue...

journal_title：Progress in brain research

authors： Jones I,Lendon C,Coyle N,Robertson E,Brockington I,Craddock N

更新日期：2001-01-01 00:00:00

abstract：:This investigation was designed to study the role of muscarinic receptor subtypes in the cardiovascular responses elicited by microinjection of cholinergic agonists in the intermediate portion of the NTS, the VLPA and VLDA areas and the IML of the spinal cord. Microinjections of L-glutamate (1.77 nmol in 20-50 nl in 0...

journal_title：Progress in brain research

authors： Sapru HN

更新日期：1989-01-01 00:00:00

abstract：:In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...

journal_title：Progress in brain research

authors： Henriques DY,Medendorp WP,Khan AZ,Crawford JD

更新日期：2002-01-01 00:00:00

abstract：:Parkinson's disease (PD) as a motor disorder is pathologically featured by the loss of dopaminergic neurons of the substantia nigra compacta (SNc) and the consequent depletion of dopamine in the striatum. However, motor signs are detectable when the loss of dopaminergic striatal terminals exceeds to the dopaminergic n...

journal_title：Progress in brain research

authors： Lafuente JV,Requejo C,Ugedo L

更新日期：2019-01-01 00:00:00