Abstract:
:Regaining any locomotor function after spinal cord injury is not only of immediate importance for affected patients but also for clinical research as it allows to investigate mechanisms underlying motor impairment and locomotor recovery. Clinical scores inform on functional outcomes that are clinically meaningful to value effects of therapy while they all lack the ability to explain underlying mechanisms of recovery. For this purpose, more elaborate recordings of walking kinematics combined with assessments of spinal cord conductivity and muscle activation patterns are required. A comprehensive assessment framework comprising of multiple complementary modalities is necessary. This will not only allow for capturing even subtle changes induced by interventions that are likely missed by standard clinical outcome measures. It will be fundamental to attribute observed changes to naturally occurring spontaneous recovery in contrast to specific changes induced by novel therapeutic interventions beyond the improvements achieved by conventional therapy.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Awai L,Curt Adoi
10.1016/bs.pbr.2014.12.004subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-14eissn
0079-6123issn
1875-7855pii
S0079-6123(14)00037-5journal_volume
218pub_type
杂志文章,评审abstract::Motor control of different segments of the body with multiple degrees of freedom appears to be coordinated by utilizing preferred axes of motor activity. This hypothesis may also be applied to vestibular control of posture. To explore this question we studied the anatomical relationship between the head and the cervic...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62282-7
更新日期:1993-01-01 00:00:00
abstract::Paired organotypic explants from rat occipital cortex were cultured for up to three weeks in the presence of selective blockers of amino acid receptor blockers, during which period spontaneous action potential generation was monitored electrophysiologically. In contrast to isolated explants (Corner, M.A., van Pelt, J....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)47018-6
更新日期:2005-01-01 00:00:00
abstract::The following chapter offers an overview of results of experimental studies conducted among healthy individuals examining the effects of acute administration of Δ9-THC and other cannabinoids, alone or in combination, on brain function and behavior, also as a function of previous cannabis exposure. In light of their me...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2018.08.010
更新日期:2018-01-01 00:00:00
abstract::The noradrenergic (NA) afferent projection to the cerebellar cortex, which originates mainly from the locus coeruleus (LC), may act on the target neurons by utilizing both alpha- and beta-adrenoceptors. Experiments performed in decerebrate cats have shown that unilateral injection into the vermal cortex of the cerebel...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63828-5
更新日期:1991-01-01 00:00:00
abstract::In addition to its peripheral secretion from the neurohypophysis, the neuropeptide vasopressin (VP) is released within the mammalian brain from probably all parts of the neuronal membrane. In particular the development of brain microdialysis in vivo together with blood microdialysis or blood sampling provides the adva...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61571-x
更新日期:1998-01-01 00:00:00
abstract::Neuroimaging studies of major depression have identified neurophysiological abnormalities in multiple areas of the prefrontal cortex (PFC), the amygdala, and related parts of the striatum and thalamus. Some of these abnormalities are mood state-dependent, and appear in regions where cerebral blood flow (CBF) increases...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(00)26027-5
更新日期:2000-01-01 00:00:00
abstract::The management of urinary tract dysfunction is crucial for the health and well-being of people with spinal cord injury. Devices, specifically catheters, play an important role in the daily regime of bladder management for most people with spinal cord injury. However, the high incidence of complications associated with...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)52011-9
更新日期:2006-01-01 00:00:00
abstract::While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)43025-2
更新日期:2004-01-01 00:00:00
abstract::An essential component of the brain extracellular space is the extracellular matrix contributing to the spatial assembly of cells by binding cell-surface adhesion molecules, supporting cell migration, differentiation, and tissue development. The most interesting and complex functions of the central nervous system are ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63486-3.00010-4
更新日期:2014-01-01 00:00:00
abstract::According to the neural efficiency hypothesis, brighter individuals might be characterized by lower and topographically more differentiated brain activation than less intelligent individuals, presumably reflecting a more specialized recruitment of task-related areas. The findings of several studies analyzing the event...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)59011-9
更新日期:2006-01-01 00:00:00
abstract::PTSD arises by definition as a direct consequence of the experience of an acute severe stressor. The formation of traumatic memory and its extinction, sympathetic and adrenocortical stress systems activity in relation to individual vulnerability form the core of animal models for PTSD. ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)67008-3
更新日期:2008-01-01 00:00:00
abstract::The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)00006-4
更新日期:2008-01-01 00:00:00
abstract::Basic tendencies to detect and respond to significant events are present in the simplest single cell organisms and persist throughout all invertebrates and vertebrates. Within vertebrates, the overall brain plan is highly conserved, though differences in size and complexity also exist. The forebrain differs the most b...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53860-4.00021-0
更新日期:2012-01-01 00:00:00
abstract::Local recurrent connections endow the cerebellar cortex with an intrinsic dynamics. We performed computer simulations to predict the frequency bands of the oscillations that will most likely emerge. Feedback inhibition from the Golgi to the granule cells induced 10-50 Hz oscillations, the period at resonance being app...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)48015-7
更新日期:2005-01-01 00:00:00
abstract::What are the building blocks of our visual representations? Whatever we look at, the things we see will have some feature variability: even snow is not purely white but has a range of shades of white. However, in most studies investigating visual perception, homogeneous displays with all stimuli having a very limited ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.07.001
更新日期:2017-01-01 00:00:00
abstract::Findings on nonprimate mammals place the issue of mother-infant lateralized relations in a broader context, demonstrating that humans are one of many species showing this feature. The remarkable interspecies consistency in the direction of lateralization points to a continuity between lateralized mother-infant interac...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2018.06.003
更新日期:2018-01-01 00:00:00
abstract::Swallowing is an essential function in our daily life; nevertheless, stroke or other neurodegenerative diseases can cause the malfunction of swallowing function, ie, dysphagia. The objectives of this review are to understand the neural and cortical basis of swallowing and tongue, and review the latest techniques on th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2016.03.014
更新日期:2016-01-01 00:00:00
abstract::It was postulated that the perceived association of visual features is based on the synchronization of those neural signals that are activated by a coherent visual object. Two types of synchronized cortical signals were found by us in cat and monkey visual cortex, and were proposed as candidates for feature associatio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)60556-7
更新日期:1994-01-01 00:00:00
abstract::Spinal cord injuries often lead to disorders in the control of autonomic function, including problems with blood pressure regulation, voiding, defecation and reproduction. The root cause of all these problems is the destruction of brain pathways that control spinal autonomic neurons lying caudal to the lesion. Changes...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)52001-6
更新日期:2006-01-01 00:00:00
abstract::Cerebral malformations are best understood as abnormal tissue morphogenesis in the context of disorders of ontogenesis. In neuroembryology, the timing of onset and duration of abnormal genetic expression and neurodevelopmental processes are primordial and must always be assessed, regardless whether the dysgenesis is p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63326-2.00010-7
更新日期:2014-01-01 00:00:00
abstract::Mechanism is at the heart of understanding, and this chapter addresses underlying brain mechanisms and pathways of cognition and the impact of sleep on these processes, especially those serving learning and memory. This chapter reviews the current understanding of the relationship between sleep/waking states and cogni...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53702-7.00001-4
更新日期:2010-01-01 00:00:00
abstract::The BBB is a target for some peptide signals, as demonstrated by our group for arginine-vasopressin (AVP) and atriopeptin (ANP). Peptide molecules contacting the luminal surface of endothelial cells interact with specific high-affinity binding sites. The minimal simple diffusion of peptide molecules across the layer o...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62330-4
更新日期:1992-01-01 00:00:00
abstract::Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache....
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.05.009
更新日期:2020-01-01 00:00:00
abstract::Understanding how action perception, embodiment, and emotion interact is essential for advancing knowledge about how we perceive and interact with each other in a social world. One tool that has proved particularly useful in the past decade for exploring the relationship between perception, action, and affect is dance...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2018.03.012
更新日期:2018-01-01 00:00:00
abstract::Elucidation of the molecular basis of mammalian circadian rhythms has progressed dramatically in recent years through the characterization of mouse mutants. With the implementation of numerous mouse genetics programs, comprehensive sets of mutations in genes affecting circadian output measures have been generated. Alt...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-59427-3.00015-0
更新日期:2012-01-01 00:00:00
abstract::High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related di...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61561-7
更新日期:1998-01-01 00:00:00
abstract::Alzheimer's disease (AD), the most common type of adult-onset dementia, is characterized by a variety of brain abnormalities, including degeneration of certain populations of nerve cells, alterations in the neuronal cytoskeleton, and the abnormal deposition of amyloid within brain parenchyma. Pathogenetic processes th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63186-6
更新日期:1990-01-01 00:00:00
abstract::Characteristic features of autism include atypical social perception and social-communication skills, and atypical visual attention, alongside rigid and repetitive thinking and behavior. Debate has focused on whether the later emergence of atypical social skills is a consequence of attention problems early in life, or...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53884-0.00025-7
更新日期:2011-01-01 00:00:00
abstract::This chapter reviews research that focuses on the effects of emotionality of single words, and of simple phrases, on event-related brain potentials when these are presented visually in various tasks. In these studies, presentation of emotionally evocative language material has consistently elicited a late (c. 300-600 ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)56009-1
更新日期:2006-01-01 00:00:00
abstract::Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have c...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)63012-X
更新日期:2007-01-01 00:00:00