Abstract：
:Elucidation of the molecular basis of mammalian circadian rhythms has progressed dramatically in recent years through the characterization of mouse mutants. With the implementation of numerous mouse genetics programs, comprehensive sets of mutations in genes affecting circadian output measures have been generated. Although incomplete, existing arrays of mutants have been instrumental in our understanding of how the internal SCN clock interacts with the environment and how it conveys its rhythm to remote oscillators. The use of ENU mutagenesis has proven to be a significant contributor, generating mutations leading to subtle and distinct alterations in circadian protein function. In parallel, progress with mouse gene targeting allows one to study gene function in depth by ablating it entirely, in specific tissues at specific times, or by targeting specific functional domains. This has culminated in worldwide efforts to target every gene in the mouse genome allowing researchers to study multiple gene targeting effects systematically.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Anand SN,Edwards JK,Nolan PMdoi
10.1016/B978-0-444-59427-3.00015-0subject
Has Abstractpub_date
2012-01-01 00:00:00pages
247-265eissn
0079-6123issn
1875-7855pii
B978-0-444-59427-3.00015-0journal_volume
199pub_type
杂志文章abstract：:Most people are experts in face recognition. We propose that the special status of this particular body part in telling individuals apart is the result of a developmental process that heavily biases human infants and children to attend towards the eyes of others. We review the evidence supporting this proposal, includ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(07)64018-7
更新日期：2007-01-01 00:00:00
abstract：:Paired organotypic explants from rat occipital cortex were cultured for up to three weeks in the presence of selective blockers of amino acid receptor blockers, during which period spontaneous action potential generation was monitored electrophysiologically. In contrast to isolated explants (Corner, M.A., van Pelt, J....
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(04)47018-6
更新日期：2005-01-01 00:00:00
abstract：:In our overview, we will attempt to justify the use of animal models and suggest that it is the only way to make the successive transitions between changes occurring at the molecular and cellular levels and changes at the level of behaviour in the intact organism. We will also stress the importance of criteria that ha...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(07)00016-7
更新日期：2008-01-01 00:00:00
abstract：:Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradua...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-62604-2.00018-6
更新日期：2013-01-01 00:00:00
abstract：:Deficits in motivation are at the core of many neuropsychiatric disorders, including major depressive disorder (MDD). Research in MDD has been heavily focused on anhedonia and depression or negative/positive symptoms of depression, with less research attention focused on the dysregulation of motivational processes. Op...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2018.07.009
更新日期：2018-01-01 00:00:00
abstract：:Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when physiological inhibitory cerebellar input, namely of the flocculus, to the vestibular nuclei is inhibited. The second most frequent form of acquired nystagmus is upbeat nystagmus (UBN). UBN is...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00676-6
更新日期：2008-01-01 00:00:00
abstract：:Partly due to the failure of anthropology to productively engage the fields of psychology and neuroscience, investigations in cultural neuroscience have occurred largely without the active involvement of anthropologists or anthropological theory. Dramatic advances in the tools and findings of social neuroscience have ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(09)17803-2
更新日期：2009-01-01 00:00:00
abstract：:VLBW infants are at risk of lesions including intraventricular haemorrhage and periventricular leucomalacia. Those with normal IQ still present with reading difficulties. Oculomotor performance was assessed on 14 VLBWs (IQ > 85) and 15 full-term age-matched controls. Anti-saccade errors were significantly higher for t...
journal_title：Progress in brain research
pub_type： 临床试验,杂志文章
doi：10.1016/S0079-6123(02)40070-2
更新日期：2002-01-01 00:00:00
abstract：:The visual system is tied to the retina. Because the eyes move in the orbit, and the head moves on the body, accurate location of an object in extrapersonal space cannot simply result from a visual signal. Instead, the retinal signal must be combined with an estimate of where the eyes are in the orbit, and where the h...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00606-7
更新日期：2008-01-01 00:00:00
abstract：:Neurons in the midbrain superior colliculus (SC) have the ability to integrate information from different senses to profoundly increase their sensitivity to external events. This not only enhances an organism's ability to detect and localize these events, but to program appropriate motor responses to them. The surviva...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53752-2.00007-2
更新日期：2011-01-01 00:00:00
abstract：:The present study involves the effects on corticotropin (ACTH) release of neuro- and thymoleptic tricyclic antidepressant compounds (TrcACs: chlorpromazine, promethazine, haloperidol, imipramine, amitriptyline) and their interactions with lysine-8-vasopressin (LVP) and corticosterone (B). As an in vitro model, 14-day ...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62322-5
更新日期：1992-01-01 00:00:00
abstract：:The role of the vesitibulo-cerebellum of the rabbit in the control of the vestibulo-ocular response (VOR) and optokinetic response (OKR) reflexes was investigated by bilateral microinjections, into the flocculus, of substances affecting GABAergic or noradrenergic neurotransmission. GABA, the main transmitter through w...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63829-7
更新日期：1991-01-01 00:00:00
abstract：:The Tibetan Buddhist classification of mind, its divisions and the system of meditation practices aimed at achieving ideal states of being are a complex presentation of psychological, behavioral and spiritual concepts and processes that demand thorough understanding before assessing their value and outcome (Yeshe, 199...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)62160-3
更新日期：2000-01-01 00:00:00
abstract：:Various growth factors are present in the hippocampal formation and appear responsible for the prominent plasticity of this brain area. Although hormone-like growth-promoting polypeptides are the best known, recent studies emphasize the importance in the growth response of molecules such as laminin proteoglycans, neur...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)61261-3
更新日期：1990-01-01 00:00:00
abstract：:In vivo functional imaging has provided objective evidence for the integration and function of nigral grafts in the brains of patients with Parkinson's disease. Clinical trials with the use of positron emission tomography have shown that transplants of human dopamine-rich fetal ventral mesencephalic tissue can survive...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-59575-1.00009-0
更新日期：2012-01-01 00:00:00
abstract：:We tend to regard consciousness as a fundamentally subjective phenomenon, yet we can only study it scientifically if it has objective, publicly visible, manifestations. This creates a central, recurring, tension in consciousness science which remains unresolved. On one 'objectivist' view, consciousness is not merely r...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(09)17701-4
更新日期：2009-01-01 00:00:00
abstract：:We studied visually guided behavior and the visual response properties of single auditory cortex (A1) neurons in neonatally operated hamsters with surgically induced, permanent, ectopic retinal projections to auditory thalamic nuclei and to visual thalamic nuclei which normally receive little direct retinal input. The...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(01)34029-3
更新日期：2001-01-01 00:00:00
abstract：:Compensatory electromyographic (EMG) responses and several biomechanical parameters were studied following impulsive disturbance of the limbs during stance of human volunteers on a treadmill. Treadmill acceleration impulses were backwards or forwards directed, or their initial direction was reversed after 30 ms. Backw...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62238-4
更新日期：1989-01-01 00:00:00
abstract：:The human brain is often characterized in terms of a duality, with the left and right brains serving complementary functions, and even individuals are sometimes classified as either "left-brained" or "right-brained." Recent evidence from brain imaging shows that hemispheric asymmetry is multidimensional, comprised of ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2019.04.041
更新日期：2019-01-01 00:00:00
abstract：:Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending (sensory) pathways and descending (motor) nerve pathways without the perspective of complete functional recovery. Future spinal cord repair strategies should comprise a multi-factorial approach addressing several issues, includin...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)46029-9
更新日期：2004-01-01 00:00:00
abstract：:Resting state functional connectivity (rsFC) evaluated by detecting temporal co-variation of BOLD signals across multiple brain regions undergoes three major changes following sleep deprivation that indicate the occurrence of sleep intrusions; a loss of integration within networks like the default mode network as well...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2019.02.009
更新日期：2019-01-01 00:00:00
abstract：:The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective o...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-53815-4.00011-X
更新日期：2011-01-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) studies performed during both waking rest and sleep show that the brain is continually active in distinct patterns that appear to reflect its underlying functional connectivity. In this review, potential sources that contribute to spontaneous fMRI activity will be discussed...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53839-0.00019-3
更新日期：2011-01-01 00:00:00
abstract：:The major point of this chapter is that there is evidence to support the idea that cervical headache might not only result from injured somatic structures in the neck but also occur because of interactions with visceral organs. The complex arrangement of convergent inputs from somatic and visceral afferent fibers and ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)62140-8
更新日期：2000-01-01 00:00:00
abstract：:Retinogeniculate connections are one of the most striking examples of connection specificity within the visual pathway. In almost every connection there is one dominant afferent cell per geniculate cell, and both afferent and geniculate cells have very similar receptive fields. The remarkable specificity and strength ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)54001-4
更新日期：2006-01-01 00:00:00
abstract：:Findings on nonprimate mammals place the issue of mother-infant lateralized relations in a broader context, demonstrating that humans are one of many species showing this feature. The remarkable interspecies consistency in the direction of lateralization points to a continuity between lateralized mother-infant interac...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2018.06.003
更新日期：2018-01-01 00:00:00
abstract：:An unresolved issue in visual motion perception is how distinct are the processes underlying 'first-order' and 'second-order' motion. The former is defined by spatio-temporal variations of luminance and the latter by spatio-temporal variations in other image attributes such as contrast or depth, for example. Using neu...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)14414-7
更新日期：2004-01-01 00:00:00
abstract：:Over the past three decades, developmental neurobiologists have made tremendous progress in defining basic principles of brain development. This work has changed the way we think about how brains develop. Thirty years ago, the dominant model was strongly deterministic. The relationship between brain and behavioral dev...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53884-0.00015-4
更新日期：2011-01-01 00:00:00
abstract：:Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous system and have been implicated in multiple behavioral paradigms and pathological conditions. Nicotinic therapeutic interventions require an extensive characterization of native nAChRs including mapping of their distribution and f...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)45007-3
更新日期：2004-01-01 00:00:00
abstract：:Miniature eye movements occur involuntarily during visual fixation. The most prominent contribution to these fixational eye movements is generated by microsaccades, which are rapid small-amplitude saccades with a rate of about one per second. Recent work demonstrates that microsaccades are optimized to counteract perc...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)54009-9
更新日期：2006-01-01 00:00:00
