The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous system.

Abstract:

:Vasopressin (VP) is one of the principal neurotransmitters of the suprachiasmatic nucleus (SCN). By means of anatomical, physiological and electrophysiological techniques we have demonstrated that VP containing pathways from the SCN serve to affect neuroendocrine and 'autonomic' neurons in the paraventricular nucleus. By direct and indirect connections VP serves to inhibit corticosterone secretion, not only by affecting ACTH secretion but also by controlling the adrenal cortex via a neuronal route. Apart from controlling the pineal and adrenal, we also observed that the SCN is able to influence the heart. Subjecting rats or humans to light affects heart rate in a dose-dependent manner. These results suggest an important role for the SCN and VP in the SCN in the regulation of neuroendocrine and autonomic functions.

journal_name

Prog Brain Res

authors

Buijs RM,Hermes MH,Kalsbeek A

doi

10.1016/s0079-6123(08)61581-2

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

365-82

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)61581-2

journal_volume

119

pub_type

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