Do sleep complaints contribute to age-related cognitive decline?

Abstract:

:The cognitive changes that occur with ageing are usually referred to as 'age-related cognitive decline'. The most pronounced changes may be found in the executive functions that require integrity of the prefrontal cortical circuitry. With age, sleep also changes profoundly, with more sleep fragmentation, earlier awakenings and less slow wave sleep as its main features. Interestingly, experimental sleep deprivation studies in healthy young adults showed a particularly consistent effect on executive functions, suggesting that sleep problems might contribute to the cognitive changes accompanying older age. We here investigate this possibility by reviewing reports on age-related and insomnia-related changes in cognition and brain function and structure, as found in studies investigating subjective complaints, objective functioning in everyday life, neuropsychological assessment, psychometry, structural and functional magnetic resonance imaging, electroencephalography, positron emission tomography and transcranial magnetic stimulation. The chapter focuses on the 'normal' age-related sleep changes that are experienced as insomnia - that is, fragmentation of sleep, more superficial sleep, more wake after sleep onset and earlier awakenings - rather than on specific sleep disturbances as sleep-disordered breathing, restless legs or periodic limb movements during sleep, for all of which the risk increases with age. It turned out that relatively few studies directly addressed the question whether elderly with different degrees of sleep complaints are differentially affected by 'age-related cognitive decline'. Still, several similarities between age-related and insomnia-related cognitive and brain changes are apparent, notably with respect to performance requiring integrity of the prefrontal cortical system. We suggest that at least part of what we regard as age-related changes may, in fact, be due to poor sleep, which is in some cases a treatable condition. Further research directly comparing aged good sleepers versus aged insomniacs will need to elucidate how sleep disturbances are involved in the cognitive, structural and functional changes observed with increasing age. The findings suggest that discrimination of subtypes of poor sleep at high age will aid in understanding the mechanisms by which it affects cognition and brain function.

journal_name

Prog Brain Res

authors

Altena E,Ramautar JR,Van Der Werf YD,Van Someren EJ

doi

10.1016/B978-0-444-53702-7.00011-7

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

181-205

eissn

0079-6123

issn

1875-7855

pii

B978-0-444-53702-7.00011-7

journal_volume

185

pub_type

杂志文章,评审
  • Treatment of refractory Parkinson's disease with adrenal medullary autografts utilizing two-stage surgery.

    abstract::Treatment of refractory PD with autologous adrenal medullary implants utilizing two-stage surgery warrants further investigation. This transplantation technique is associated with prolonged transplant area BBB disruption which may require a change in medical treatment strategies including the withdrawal of peripheral ...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)62658-8

    authors: Petruk KC,Wilson AF,Schindel DR,Witt NJ,McLean DR,McFarland PA,Johnston RG,McPhee MS,Martin WR,Calne DB

    更新日期:1990-01-01 00:00:00

  • ECM in brain aging and dementia.

    abstract::An essential component of the brain extracellular space is the extracellular matrix contributing to the spatial assembly of cells by binding cell-surface adhesion molecules, supporting cell migration, differentiation, and tissue development. The most interesting and complex functions of the central nervous system are ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63486-3.00010-4

    authors: Morawski M,Filippov M,Tzinia A,Tsilibary E,Vargova L

    更新日期:2014-01-01 00:00:00

  • Attention for action during error correction.

    abstract::While the role of attention in selecting visual attributes is well acknowledged, relatively less is known about the mechanisms that facilitate the selection of actions during goal-directed behaviors. The notion of an executive attention has provided a particularly fruitful framework to understand how the brain coordin...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)17613-6

    authors: Sharika KM,Ray S,Murthy A

    更新日期:2009-01-01 00:00:00

  • Fatigue with up- vs downregulated brain arousal should not be confused.

    abstract::Fatigue is considered to be an important and frequent factor in motivation problems. However, this term lacks clinical and pathophysiological validity. Semantic precision has to be improved. Lack of drive and tiredness with increased sleepiness as observed in fatigue in the context of inflammatory and immunological pr...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2016.06.001

    authors: Hegerl U,Ulke C

    更新日期:2016-01-01 00:00:00

  • How the orbitofrontal cortex contributes to decision making - a view from neuroscience.

    abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)01306-5

    authors: Volz KG,von Cramon DY

    更新日期:2009-01-01 00:00:00

  • The effects of surgery and anesthesia on memory and cognition.

    abstract::This chapter describes current findings from the research into postoperative cognitive dysfunction (POCD) following cardiac and non-cardiac surgery in older adults. The evidence suggests that a significant proportion of patients show POCD in the early weeks following surgery and anesthesia. Specific domains of cogniti...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)00026-X

    authors: Caza N,Taha R,Qi Y,Blaise G

    更新日期:2008-01-01 00:00:00

  • Hector Berlioz and his Vesuvius: an analysis of historical evidence from an epileptological perspective.

    abstract::The epileptologically informed in-depth analysis of auto- and heteroanamnestic historical sources supports the hypothesis that Hector Berlioz (1803-1869) might have suffered from a photosensitive idiopathic generalized epilepsy syndrome with absences, absence status, myoclonic seizures, and bilateral tonic-clonic seiz...

    journal_title:Progress in brain research

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/bs.pbr.2014.11.007

    authors: Altenmüller DM

    更新日期:2015-01-01 00:00:00

  • Neurological phenotypes for Down syndrome across the life span.

    abstract::This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as aberrations in gross brain structure as well as characteristic microdysgenetic changes. As the result of these morphological abnormalities, brain circuit...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-54299-1.00006-6

    authors: Lott IT

    更新日期:2012-01-01 00:00:00

  • Neural mechanisms underlying the milk ejection burst and reflex.

    abstract::One of the more interesting and complex phenomena involving neurohypophysial hormones is the milk ejection reflex and the events surrounding it. Accordingly, many investigations over the years have taken up the challenge of elucidating its myriad aspects. Much has been learned from in vivo preparations about the seque...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)00414-7

    authors: Hatton GI,Wang YF

    更新日期:2008-01-01 00:00:00

  • Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation.

    abstract::In addition to its peripheral secretion from the neurohypophysis, the neuropeptide vasopressin (VP) is released within the mammalian brain from probably all parts of the neuronal membrane. In particular the development of brain microdialysis in vivo together with blood microdialysis or blood sampling provides the adva...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61571-x

    authors: Landgraf R,Wotjak CT,Neumann ID,Engelmann M

    更新日期:1998-01-01 00:00:00

  • Axonal and synaptic remodeling in the mature cerebellar cortex.

    abstract::By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to t...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)48005-4

    authors: Cesa R,Strata P

    更新日期:2005-01-01 00:00:00

  • Transcranial magnetic stimulation (TMS) for treatment of chronic tinnitus: clinical effects.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method used to induce electrical current in the brain through impulses of strong magnetic fields applied externally. The technique can relieve tinnitus by modulating the excitability of neurons in the auditory cortex to decrease the hyperexcitabilit...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66034-8

    authors: Kleinjung T,Steffens T,Londero A,Langguth B

    更新日期:2007-01-01 00:00:00

  • Expert music performance: cognitive, neural, and developmental bases.

    abstract::In this chapter, we explore what happens in the brain of an expert musician during performance. Understanding expert music performance is interesting to cognitive neuroscientists not only because it tests the limits of human memory and movement, but also because studying expert musicianship can help us understand skil...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2014.11.021

    authors: Brown RM,Zatorre RJ,Penhune VB

    更新日期:2015-01-01 00:00:00

  • Social and attention factors during infancy and the later emergence of autism characteristics.

    abstract::Characteristic features of autism include atypical social perception and social-communication skills, and atypical visual attention, alongside rigid and repetitive thinking and behavior. Debate has focused on whether the later emergence of atypical social skills is a consequence of attention problems early in life, or...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53884-0.00025-7

    authors: Elsabbagh M,Holmboe K,Gliga T,Mercure E,Hudry K,Charman T,Baron-Cohen S,Bolton P,Johnson MH,BASIS Team.

    更新日期:2011-01-01 00:00:00

  • Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.

    abstract::The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase th...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)00006-4

    authors: Abel T,Nguyen PV

    更新日期:2008-01-01 00:00:00

  • Predictive disjunctive pursuit of virtual images perceived to move in depth.

    abstract::Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00666-3

    authors: Fu P,Chang R,O'Beirne K,King WM

    更新日期:2008-01-01 00:00:00

  • The active role of dendrites in the regulation of magnocellular neurosecretory cell behavior.

    abstract::The interactions of the dendritically released neuropeptides vasopressin and oxytocin with co-released neuroactive substances such as opioids and nitric oxide are reviewed. Endogenous opioids regulate magnocellular neurons at the level of the supraoptic nucleus and the relationship of dendritically released peptides a...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(02)39021-6

    authors: Ludwig M,Sabatier N,Dayanithi G,Russell JA,Leng G

    更新日期:2002-01-01 00:00:00

  • Eventual sport performance level: What about the role of type of sport, perception of critical life events, and practice quality?

    abstract::The target article describes an interesting study, which provides some challenging findings regarding athletes' pathway to excellence. The suggested links between critical life events, need for success, personal characteristics, and eventual performance level make sense from a psychodynamic perspective. This commentar...

    journal_title:Progress in brain research

    pub_type: 评论,杂志文章

    doi:10.1016/bs.pbr.2017.02.004

    authors: Toering T

    更新日期:2017-01-01 00:00:00

  • Developmental changes in rhythmic spinal neuronal activity in the rat fetus.

    abstract::In the developing rat spinal cord, formation and differentiation of the central pattern generator for locomotion occur during the prenatal period. Early on, excitatory synaptic transmission mediated by glycine receptors plays a leading role for rhythmogenesis, at a later stage, followed by glutamate-receptor-mediated ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(03)43005-7

    authors: Kudo N,Nishimaru H,Nakayama K

    更新日期:2004-01-01 00:00:00

  • The problem of unreportable awareness.

    abstract::We tend to regard consciousness as a fundamentally subjective phenomenon, yet we can only study it scientifically if it has objective, publicly visible, manifestations. This creates a central, recurring, tension in consciousness science which remains unresolved. On one 'objectivist' view, consciousness is not merely r...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)17701-4

    authors: Zeman A

    更新日期:2009-01-01 00:00:00

  • The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous system.

    abstract::Vasopressin (VP) is one of the principal neurotransmitters of the suprachiasmatic nucleus (SCN). By means of anatomical, physiological and electrophysiological techniques we have demonstrated that VP containing pathways from the SCN serve to affect neuroendocrine and 'autonomic' neurons in the paraventricular nucleus....

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61581-2

    authors: Buijs RM,Hermes MH,Kalsbeek A

    更新日期:1998-01-01 00:00:00

  • Visuomotor transformations for eye-hand coordination.

    abstract::In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(02)40060-X

    authors: Henriques DY,Medendorp WP,Khan AZ,Crawford JD

    更新日期:2002-01-01 00:00:00

  • Involvement of astrocytes in neurovascular communication.

    abstract::The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional role...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2016.02.001

    authors: Nuriya M,Hirase H

    更新日期:2016-01-01 00:00:00

  • Some organizing principles for the control of movement based on olivocerebellar physiology.

    abstract::Motor control is defined as the process of restricting the output of the motor nervous system so that meaningful and coordinated behavior ensues. The high dimensionality of the computation underlying motor control is presented and a simplifying framework is outlined. Evidence that movements are performed non-continuou...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63380-4

    authors: Welsh JP,Llinás R

    更新日期:1997-01-01 00:00:00

  • Molecular substrates of plasticity in the developing visual cortex.

    abstract::Ocular dominance plasticity may be the paradigmatic in vivo model of activity-dependent plasticity. More than four decades of intense research has delineated the network-level rules that govern synaptic change in this model. The recent characterization of a murine model for ocular dominance plasticity has facilitated ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)47008-3

    authors: Taha SA,Stryker MP

    更新日期:2005-01-01 00:00:00

  • Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus.

    abstract::Nitric oxide (NO) is widespread in the nervous system and is thought to play a role in a variety of different neuronal functions, including learning and memory (see other chapters, this volume). A number of behavioral studies have indicated that NO is involved in several types of learning such as motor learning (Yanag...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63206-9

    authors: Hawkins RD,Son H,Arancio O

    更新日期:1998-01-01 00:00:00

  • Spinal cord neural organization controlling the urinary bladder and striated sphincter.

    abstract::The storage and elimination of urine requires the coordination of activity between the autonomic nervous system (thoracolumbar sympathetic and sacral parasympathetic divisions) controlling the urinary bladder and urethra and the lumbosacral somatic motoneurons innervating the striated sphincter and pelvic floor muscle...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(02)37008-0

    authors: Shefchyk SJ

    更新日期:2002-01-01 00:00:00

  • Is infantile esotropia subcortical in origin?

    abstract::Essential infantile esotropia (EIE) is often attributed to a primary disturbance within the visual cortex based upon the findings of monocular horizontal optokinetic asymmetry and correlative horizontal motion detection asymmetry. However, these physiologic aberrations conform to what would be observed if the visual c...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2019.04.001

    authors: Brodsky MC

    更新日期:2019-01-01 00:00:00

  • Monkey primary somatosensory cortex has a proprioceptive representation of eye position.

    abstract::The visual system is tied to the retina. Because the eyes move in the orbit, and the head moves on the body, accurate location of an object in extrapersonal space cannot simply result from a visual signal. Instead, the retinal signal must be combined with an estimate of where the eyes are in the orbit, and where the h...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00606-7

    authors: Zhang M,Wang X,Goldberg ME

    更新日期:2008-01-01 00:00:00

  • Thalamic relays and cortical functioning.

    abstract::Studies on the visual thalamic relays, the lateral geniculate nucleus and pulvinar, provide three key properties that have dramatically changed the view that the thalamus serves as a simple relay to get information from subcortical sites to cortex. First, the retinal input, although a small minority (7%) in terms of n...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)49009-3

    authors: Sherman SM

    更新日期:2005-01-01 00:00:00