Abstract:
:The present chapter outlines current thinking regarding serotonin and dopamine in schizophrenia. Each has individually been linked to theories regarding the illness' pathophysiology although the focus here is on their interactive role, a model that has driven drug development in the field for the last 10-15 years. With clozapine as a prototype, a new class of 'atypical' antipsychotics entered the clinical market, hinged predominantly on the notion that these agents were superior to conventional antipsychotics through their ratio of serotonin 5-HT(2)/dopamine D(2) binding. This model has since been challenged both clinically and theoretically, but interest in serotonin-dopamine interactions remains high in the face of a broader conceptualization of schizophrenia's symptom domains, in combination with a shift in the perceived role of dopamine vis-à-vis these different clinical features. At present, there is particular interest in the 5-HT(1A), 5-HT(2C), 5-HT(6) and 5-HT(7) receptors as the search for improved pharmacological treatments for schizophrenia continues.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Remington Gdoi
10.1016/S0079-6123(08)00906-0subject
Has Abstractpub_date
2008-01-01 00:00:00pages
117-40eissn
0079-6123issn
1875-7855pii
S0079-6123(08)00906-0journal_volume
172pub_type
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