Abstract:
:A neural-network module with attractor dynamics has been shown recently to be robust to stochastic noise in external and internal signals, and to converge rapidly onto an output signal that is an unbiased and efficient representation of the environment. We suggest here a modular network architecture with attractor dynamics that can compute the time-varying signals that are presumably required to control arm movements. The architecture is composed of several linked modules and implements the joint torque control of a planar biomechanical model of the arm, in the presence of external dynamic perturbations. The meta-network is robust to noise and to the unreliable availability of some signals and can provide feedback correction for unexpected external perturbations.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Krouchev NI,Kalaska JFdoi
10.1016/S0079-6123(06)65025-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
395-410eissn
0079-6123issn
1875-7855pii
S0079-6123(06)65025-5journal_volume
165pub_type
杂志文章,评审abstract::Three rhythmic movements, breathing, walking, and chewing, are considered from the perspective of the emerging factors that control their coordination. This takes us beyond the concept of a core excitatory kernel and into the common principles that govern the interaction between components of the neural networks that ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53825-3.00017-6
更新日期:2011-01-01 00:00:00
abstract::Chronic epilepsy, as a consequence of status epilepticus, has been studied in animal models in order to analyze the cellular mechanisms responsible for the subsequent occurrence of spontaneous seizures. Status epilepticus, induced by either kainic acid or pilocarpine or by prolonged electrical stimulation, causes a ch...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)35007-6
更新日期:2002-01-01 00:00:00
abstract::This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as aberrations in gross brain structure as well as characteristic microdysgenetic changes. As the result of these morphological abnormalities, brain circuit...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-54299-1.00006-6
更新日期:2012-01-01 00:00:00
abstract::The noradrenergic (NA) afferent projection to the cerebellar cortex, which originates mainly from the locus coeruleus (LC), may act on the target neurons by utilizing both alpha- and beta-adrenoceptors. Experiments performed in decerebrate cats have shown that unilateral injection into the vermal cortex of the cerebel...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63828-5
更新日期:1991-01-01 00:00:00
abstract::Follicular development and ovulation are strongly inhibited during lactation. Administration of a high dose of estrogen induces luteinizing hormone (LH) surges in ovariectomized lactating rats, suggesting that brain mechanisms regulating cyclic LH release remain intact in lactating mothers. On the other hand, tonic LH...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)33014-5
更新日期:2001-01-01 00:00:00
abstract::Humans can communicate their emotional state via facial expression and affective prosody. This chapter reviews behavioural, neuroanatomical, electrophysiological and neuroimaging studies pertaining to audiovisual integration of emotional communicative signals. Particular emphasis will be given to neuroimaging studies ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)56019-4
更新日期:2006-01-01 00:00:00
abstract::Two cortical areas that crucially contribute to the generation and maintenance of smooth pursuit eye movements (SPEM) are the medial superior temporal area (MST) and the pursuit area of the frontal eye fields (FEF). They both project to the brainstem premotor structures via different parallel pathways. A special prope...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00636-5
更新日期:2008-01-01 00:00:00
abstract::Glaucoma is a visual disorder characterized by progressive loss of retinal ganglion cells (RGCs), which is often associated with high intraocular pressure. However, mechanisms of RGC death in glaucoma still remain a mystery. Two theories have been proposed as pathogeneses of glaucoma: mechanical and vascular. We demon...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)01134-5
更新日期:2008-01-01 00:00:00
abstract::Research has outlined how self-regulation is crucial to the decision-making processes and pacing of endurance performance. There is evidence to suggest that executive function is implicated in self-regulatory processes, as the two are conceptually similar and share common brain regions such as the prefrontal cortex. T...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2018.09.011
更新日期:2018-01-01 00:00:00
abstract::The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently, deep brain stimulation in psychiatry is investigated for obsessive-compulsive ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17527-1
更新日期:2009-01-01 00:00:00
abstract::It is widely believed that mammalian CNS axons have little regenerative capacity because their environment is non-permissive to regrowth. This viewpoint is based, in large part, on the fact that in virtually all previous studies on regeneration following spinal cord injury, regenerated axonal projections have been few...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(03)43015-X
更新日期:2004-01-01 00:00:00
abstract::The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53613-6.00014-9
更新日期:2010-01-01 00:00:00
abstract::The midbrain has been shown to contain crucial nuclei for the control of vertical and torsional eye movements. Recent studies in monkeys demonstrated that midbrain lesions also affect head movements during gaze saccades, but so far clinical reports on the matter have been missing. We measured 3D eye and head movements...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00686-9
更新日期:2008-01-01 00:00:00
abstract::The Tibetan Buddhist classification of mind, its divisions and the system of meditation practices aimed at achieving ideal states of being are a complex presentation of psychological, behavioral and spiritual concepts and processes that demand thorough understanding before assessing their value and outcome (Yeshe, 199...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62160-3
更新日期:2000-01-01 00:00:00
abstract::In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)40060-X
更新日期:2002-01-01 00:00:00
abstract::Recent accounts of tinnitus development and maintenance assign an important role to central mechanisms. Residual inhibition is a frequent phenomenon in individuals with tinnitus, and refers to the fact that tinnitus can temporarily be reduced by presenting sounds or noises that inhibit tinnitus for a limited time even...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)66044-0
更新日期:2007-01-01 00:00:00
abstract::Postural instability and falls are common causes of morbidity and mortality in the second most prevalent neurodegenerative condition, Parkinson's disease (PD). Poor understanding of balance dysfunction in PD has hampered the development of novel therapeutic measures for postural instability and balance dysfunction. We...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2019.03.034
更新日期:2019-01-01 00:00:00
abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63798-x
更新日期:1991-01-01 00:00:00
abstract::The role of the superior colliculus in attending and orienting to sensory stimuli is facilitated by the presence within this midbrain nucleus of superimposed maps of different sensory modalities. We have studied the steps involved in the development of topographically-aligned maps of visual and auditory space in the f...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63340-3
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:glaucoma is the leading cause of irreversible blindness all over the world. The degree of visual field loss accounts for the severity of the disease and represents the main clinical outcome of treatment for patients affected by glaucoma. The α2 agonists, like brimonidine, emerged in the 1960s as topical opht...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.07.008
更新日期:2020-01-01 00:00:00
abstract::A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-center rhythm generator (RG) and pattern formation (PF) networks is reviewed. The model consists of interacting populations of interneurons and motoneurons described in the Hodgkin-...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)65015-2
更新日期:2007-01-01 00:00:00
abstract::A problem for studies of all cortex, including prefrontal cortex, is how to relate results to proposed subdivisions of the brain and how to compare results across species. Investigators have been highly dependent on traditional architectonic maps of neocortex. However, over the last 20 years, other methods, especially...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62673-4
更新日期:1990-01-01 00:00:00
abstract::Spinal cord injury (SCI) typically damages the long axonal tracts of the spinal cord which results in permanent disability. However, regeneration of the injured spinal cord is approaching reality according to the advances in stem cell biology. Cell transplantation therapy holds potential to lead to recovery following ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2016.12.007
更新日期:2017-01-01 00:00:00
abstract::In the neostriatum, GABAergic inhibition arises from the action of at least two classes of inhibitory interneurons, and from recurrent collaterals of the principal cells. Interneurons receive excitatory input only from extrinsic sources, and so act in a purely feedforward capacity. Feedback inhibition arises from the ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)60006-X
更新日期:2007-01-01 00:00:00
abstract::By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to t...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)48005-4
更新日期:2005-01-01 00:00:00
abstract::Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when physiological inhibitory cerebellar input, namely of the flocculus, to the vestibular nuclei is inhibited. The second most frequent form of acquired nystagmus is upbeat nystagmus (UBN). UBN is...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00676-6
更新日期:2008-01-01 00:00:00
abstract::The interactions of the dendritically released neuropeptides vasopressin and oxytocin with co-released neuroactive substances such as opioids and nitric oxide are reviewed. Endogenous opioids regulate magnocellular neurons at the level of the supraoptic nucleus and the relationship of dendritically released peptides a...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(02)39021-6
更新日期:2002-01-01 00:00:00
abstract::The main topic of this overview is an analysis of the concepts of phase and synchrony, as used in neurophysiology, in their various meanings. A number of notions related to the concepts of phase and synchrony, which are incorporated in contemporary neurophysiology, particularly in the domain of neuro-cognitive physiol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)59001-6
更新日期:2006-01-01 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous system and have been implicated in multiple behavioral paradigms and pathological conditions. Nicotinic therapeutic interventions require an extensive characterization of native nAChRs including mapping of their distribution and f...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)45007-3
更新日期:2004-01-01 00:00:00
abstract::The studies reviewed in this chapter present a convincing argument that prostaglandins have direct actions at the level of the spinal cord to enhance nociception. Furthermore, an increasing body of evidence supports the hypothesis that one important site of action of these eicosanoids is the terminals of sensory neuro...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61801-4
更新日期:1995-01-01 00:00:00