Abstract:
:GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal models of epilepsy, as well as in some genetic forms of epilepsy in humans. In this review, we provide an overview of some of the experimental data linking PV INs dysfunction with epilepsy, focusing on disorders of the specification, migration, maturation, synaptic function, or connectivity of PV INs. Furthermore, we reflect on the potential therapeutic use of cell-type specific stimulation of PV INs within active networks and on the transplantation of PV INs precursors in the treatment of epilepsy and its comorbidities.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Jiang X,Lachance M,Rossignol Edoi
10.1016/bs.pbr.2016.04.012subject
Has Abstractpub_date
2016-01-01 00:00:00pages
81-126eissn
0079-6123issn
1875-7855pii
S0079-6123(16)30038-3journal_volume
226pub_type
杂志文章,评审abstract::Regaining any locomotor function after spinal cord injury is not only of immediate importance for affected patients but also for clinical research as it allows to investigate mechanisms underlying motor impairment and locomotor recovery. Clinical scores inform on functional outcomes that are clinically meaningful to v...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2014.12.004
更新日期:2015-01-01 00:00:00
abstract::VLBW infants are at risk of lesions including intraventricular haemorrhage and periventricular leucomalacia. Those with normal IQ still present with reading difficulties. Oculomotor performance was assessed on 14 VLBWs (IQ > 85) and 15 full-term age-matched controls. Anti-saccade errors were significantly higher for t...
journal_title:Progress in brain research
pub_type: 临床试验,杂志文章
doi:10.1016/S0079-6123(02)40070-2
更新日期:2002-01-01 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptors have been implicated as a mediator of neuronal injury associated with many neurological disorders including ischemia, epilepsy, brain trauma, dementia and neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease. To this, non-selective NMDA receptor ant...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)83009-2
更新日期:2010-01-01 00:00:00
abstract::Ocular dominance plasticity may be the paradigmatic in vivo model of activity-dependent plasticity. More than four decades of intense research has delineated the network-level rules that govern synaptic change in this model. The recent characterization of a murine model for ocular dominance plasticity has facilitated ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)47008-3
更新日期:2005-01-01 00:00:00
abstract::Based on a review of anatomical and physiological findings, we suggest that the hippocampus may be viewed as a positive feedback device (autoassociator), which is capable of modifying the activity of the neocortical neurons. We examine the three-dimensional organization of evoked and spontaneous physiological patterns...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61255-8
更新日期:1990-01-01 00:00:00
abstract::Aromatase is the enzyme that catalyzes the last step of estrogen biosynthesis. It is expressed in many tissues such as the gonads, brain and adipose tissue. The regulation of the level and activity of aromatase determines the levels of estrogens that have endocrine, paracrine and autocrine effects on tissues. Estrogen...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)81012-6
更新日期:2010-01-01 00:00:00
abstract::Chronic epilepsy, as a consequence of status epilepticus, has been studied in animal models in order to analyze the cellular mechanisms responsible for the subsequent occurrence of spontaneous seizures. Status epilepticus, induced by either kainic acid or pilocarpine or by prolonged electrical stimulation, causes a ch...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)35007-6
更新日期:2002-01-01 00:00:00
abstract::Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache....
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.05.009
更新日期:2020-01-01 00:00:00
abstract::By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to t...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)48005-4
更新日期:2005-01-01 00:00:00
abstract::During the 1660s and 1670s, Thomas Willis (1621-1675) pursued an ambitious program of brain science. Instead of the speculative approach favored by René Descartes (1596-1659), Willis used comparative anatomy to figure out the workings of the brain and nerves. As a result, Willis is still cited by science writers as th...
journal_title:Progress in brain research
pub_type: 传,历史文章,杂志文章
doi:10.1016/bs.pbr.2018.10.009
更新日期:2018-01-01 00:00:00
abstract::Studies with nicotine have, from the outset, been of fundamental importance for the elucidation of physiological mechanisms. However, many nicotinic cholinoreceptors do not appear to subserve a physiological role, at least within the present framework of knowledge. The main challenge in the immediate future is to dete...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62461-9
更新日期:1989-01-01 00:00:00
abstract::Cerebral malformations are best understood as abnormal tissue morphogenesis in the context of disorders of ontogenesis. In neuroembryology, the timing of onset and duration of abnormal genetic expression and neurodevelopmental processes are primordial and must always be assessed, regardless whether the dysgenesis is p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63326-2.00010-7
更新日期:2014-01-01 00:00:00
abstract::Recent accounts of tinnitus development and maintenance assign an important role to central mechanisms. Residual inhibition is a frequent phenomenon in individuals with tinnitus, and refers to the fact that tinnitus can temporarily be reduced by presenting sounds or noises that inhibit tinnitus for a limited time even...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)66044-0
更新日期:2007-01-01 00:00:00
abstract::The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy. The overall objective o...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53815-4.00011-X
更新日期:2011-01-01 00:00:00
abstract::An unresolved issue in visual motion perception is how distinct are the processes underlying 'first-order' and 'second-order' motion. The former is defined by spatio-temporal variations of luminance and the latter by spatio-temporal variations in other image attributes such as contrast or depth, for example. Using neu...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)14414-7
更新日期:2004-01-01 00:00:00
abstract::High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related di...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61561-7
更新日期:1998-01-01 00:00:00
abstract::Experimental investigations of the lumbar sympathetic outflow to skin, skeletal muscle and viscera and the thoracic sympathetic outflow to the head and neck have shown that each target organ and tissue is supplied by one or two separate pathways which consists of sets of pre- and postganglionic neurons with distinct p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62150-0
更新日期:2000-01-01 00:00:00
abstract::Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)30018-3
更新日期:2001-01-01 00:00:00
abstract::The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While multiple growth factors and adipokines are identified in atherosclerotic lesions, as well as neurotrophins implicated in both ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)46018-4
更新日期:2004-01-01 00:00:00
abstract::John Bell, brother-surgeon of Charles Bell, was, like Charles, an outstanding surgeon and a good artist. John was one of the few who illustrated his work with their own drawings in the days before audiovisual aids were available and without the benefit of reliable drawing aids, photography and computer-aided design. C...
journal_title:Progress in brain research
pub_type: 传,历史文章,杂志文章
doi:10.1016/B978-0-444-62730-8.00006-2
更新日期:2013-01-01 00:00:00
abstract::Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have c...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)63012-X
更新日期:2007-01-01 00:00:00
abstract::The results from the language studies taken as a whole point to different developmental time courses and developmental vulnerabilities of aspects of grammatical and semantic/lexical processing. They thus provide support for conceptions of language that distinguish these subprocesses within language. Similarly, followi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)38078-6
更新日期:2002-01-01 00:00:00
abstract::Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei (SCN) co-ordinates these metabolic cycles. Circadian timing is based upon a transcriptional/post-translational negative feedback loop invol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)53015-8
更新日期:2006-01-01 00:00:00
abstract::The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-53613-6.00014-9
更新日期:2010-01-01 00:00:00
abstract::The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently, deep brain stimulation in psychiatry is investigated for obsessive-compulsive ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17527-1
更新日期:2009-01-01 00:00:00
abstract::In the "Histology of the Nervous System" (Histologie, Spanish edition, 1899, 1904; French translation, 1909, 1911; all citations are from the American translation, 1995) Cajal did not only describe the origins and central pathways of cranial nerves but his detailed observations led him to numerous conclusions about th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(02)36036-9
更新日期:2002-01-01 00:00:00
abstract::Resting state functional connectivity (rsFC) evaluated by detecting temporal co-variation of BOLD signals across multiple brain regions undergoes three major changes following sleep deprivation that indicate the occurrence of sleep intrusions; a loss of integration within networks like the default mode network as well...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2019.02.009
更新日期:2019-01-01 00:00:00
abstract::This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as aberrations in gross brain structure as well as characteristic microdysgenetic changes. As the result of these morphological abnormalities, brain circuit...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-54299-1.00006-6
更新日期:2012-01-01 00:00:00
abstract::Today's researchers are faced with a change from curiosity-driven to mandate-driven research. These two approaches are well combined within scientific networks (Actions) supported by the European Cooperation in Science and Technology (COST) program. The functioning of COST Actions, although directed only to networking...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63486-3.09999-0
更新日期:2014-01-01 00:00:00
abstract::In the developing rat spinal cord, formation and differentiation of the central pattern generator for locomotion occur during the prenatal period. Early on, excitatory synaptic transmission mediated by glycine receptors plays a leading role for rhythmogenesis, at a later stage, followed by glutamate-receptor-mediated ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(03)43005-7
更新日期:2004-01-01 00:00:00