Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome.

abstract：:Disrupted in Schizophrenia-1 (DISC1) is one of the most likely susceptibility genes for schizophrenia (SZ). DISC1 is being established as a hub protein with various functions in the pre- and postnatal development of the nervous system. Since generation of a knockout (KO) mouse has proved challenging, various alternati...

journal_title：Progress in brain research

authors： Jaaro-Peled H

更新日期：2009-01-01 00:00:00

abstract：:Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficits in consciousness, with relatively little motor or other manifestations. Impaired consciousness in absence seizures is no...

journal_title：Progress in brain research

authors： Blumenfeld H

更新日期：2005-01-01 00:00:00

abstract：:Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology. BDNF in particular has ...

journal_title：Progress in brain research

authors： Binder DK

更新日期：2007-01-01 00:00:00

abstract：:The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional role...

journal_title：Progress in brain research

authors： Nuriya M,Hirase H

更新日期：2016-01-01 00:00:00

abstract：:Object recognition and visual attention are tightly linked processes in human perception. Over the last three decades, many models have been suggested to explain these two processes and their interactions, and in some cases these models appear to contradict each other. We suggest a unifying framework for object recogn...

journal_title：Progress in brain research

authors： Walther DB,Koch C

更新日期：2007-01-01 00:00:00

abstract：:Schwann cells (SCs), when implanted in the injured spinal cord, support regeneration of axons, myelinate or ensheathe regenerated axons in a normal way, reduce cyst formation in the injured tissue, reduce secondary damage of tissue around the initial injury site, and modestly improve limb movements. If SC transplantat...

journal_title：Progress in brain research

authors： Wiliams RR,Bunge MB

更新日期：2012-01-01 00:00:00

abstract：:While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...

journal_title：Progress in brain research

authors： Drew T,Prentice S,Schepens B

更新日期：2004-01-01 00:00:00

abstract：:During walking, an increase in speed is accompanied by a decrease in the stance phase duration while the swing phase remains relatively invariant. By definition, the rhythm generator in the lumbar spinal cord controls cycle period, phase durations, and phase transitions. Our first aim was to determine if this asymmetr...

journal_title：Progress in brain research

authors： Gossard JP,Sirois J,Noué P,Côté MP,Ménard A,Leblond H,Frigon A

更新日期：2011-01-01 00:00:00

abstract：:The storage and elimination of urine requires the coordination of activity between the autonomic nervous system (thoracolumbar sympathetic and sacral parasympathetic divisions) controlling the urinary bladder and urethra and the lumbosacral somatic motoneurons innervating the striated sphincter and pelvic floor muscle...

journal_title：Progress in brain research

authors： Shefchyk SJ

更新日期：2002-01-01 00:00:00

abstract：:The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. T...

journal_title：Progress in brain research

authors： Luikart BW,Parada LF

更新日期：2006-01-01 00:00:00

abstract：:Impulsive testing, which accurately measures the gain of the vestibulo-ocular reflex (VOR) is mostly recorded from only one eye. We measured the horizontal VOR of both eyes in response to graded velocity head impulses in 14 normal subjects. VOR acceleration gains were similar for each eye in both directions at low acc...

journal_title：Progress in brain research

authors： Weber KP,Aw ST,Todd MJ,McGarvie LA,Pratap S,Curthoys IS,Halmagyi GM

更新日期：2008-01-01 00:00:00

abstract：:In this chapter, the distribution of Hsp70 in brain cell types following whole body hyperthermia is reviewed. The prevalence of Hsp70 expression in oligodendrocytes, microglia, and vascular cells in this type of stress contrasts with scarcity of Hsp70 induction in astrocytes and most neurons of the hyperthermic brain....

journal_title：Progress in brain research

authors： Pavlik A,Aneja IS

更新日期：2007-01-01 00:00:00

abstract：:Language is predominantly a left hemisphere function, yet patients with extensive damage to known language areas often recover quite well in the days to weeks to even years following focal brain injury. This recovery period can be divided into three overlapping stages: acute, subacute, and chronic, each with different...

journal_title：Progress in brain research

authors： Marsh EB,Hillis AE

更新日期：2006-01-01 00:00:00

abstract：:PTSD arises by definition as a direct consequence of the experience of an acute severe stressor. The formation of traumatic memory and its extinction, sympathetic and adrenocortical stress systems activity in relation to individual vulnerability form the core of animal models for PTSD. ...

journal_title：Progress in brain research

authors： Oitzl MS

更新日期：2008-01-01 00:00:00

abstract：:An essential component of the brain extracellular space is the extracellular matrix contributing to the spatial assembly of cells by binding cell-surface adhesion molecules, supporting cell migration, differentiation, and tissue development. The most interesting and complex functions of the central nervous system are ...

journal_title：Progress in brain research

authors： Morawski M,Filippov M,Tzinia A,Tsilibary E,Vargova L

更新日期：2014-01-01 00:00:00

abstract：:It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference....

journal_title：Progress in brain research

authors： Mogil JS,Bailey AL

更新日期：2010-01-01 00:00:00

abstract：:In the past, medicine was dominated by acute diseases. Since treatments were unknown to patients they followed their medical doctors´ directives-at least for the duration of the disease. Behavior was thus largely motivated by avoiding expected costs associated with alternative behaviors (I-must). The health challenges...

journal_title：Progress in brain research

authors： Knecht S,Kenning P

更新日期：2016-01-01 00:00:00

abstract：:Postural instability and falls are common causes of morbidity and mortality in the second most prevalent neurodegenerative condition, Parkinson's disease (PD). Poor understanding of balance dysfunction in PD has hampered the development of novel therapeutic measures for postural instability and balance dysfunction. We...

journal_title：Progress in brain research

authors： Beylergil SB,Ozinga S,Walker MF,McIntyre CC,Shaikh AG

更新日期：2019-01-01 00:00:00

abstract：:In the last few years, theorists have argued that culture can shape processes of basic visual perception. This work has primarily focused on cultural influences in nonsocial domains, such as cross-cultural differences in seeing and attending to focal stimuli versus backgrounds. Recently, researchers have begun to exam...

journal_title：Progress in brain research

authors： Freeman JB,Rule NO,Ambady N

更新日期：2009-01-01 00:00:00

abstract：:Retinal ganglion cell axons within the globe are functionally specialized being richly provided with many mitochondria. The mitochondria produce the high energy requirement for nerve conduction in the unmyelinated part of the ganglion cell axons. We have proposed that in the initiation of glaucoma, an alteration in th...

journal_title：Progress in brain research

authors： Osborne NN

更新日期：2008-01-01 00:00:00

abstract：:The epileptologically informed in-depth analysis of auto- and heteroanamnestic historical sources supports the hypothesis that Hector Berlioz (1803-1869) might have suffered from a photosensitive idiopathic generalized epilepsy syndrome with absences, absence status, myoclonic seizures, and bilateral tonic-clonic seiz...

journal_title：Progress in brain research

authors： Altenmüller DM

更新日期：2015-01-01 00:00:00

abstract：:The capacity to sustain high-intensity aerobic exercise is essential for endurance performance. Therefore, it is important to understand what is the factor limiting time to exhaustion (TTE) in healthy and fit adults. In Study 1, maximal voluntary cycling power (MVCP) was measured in 11 volunteers before and immediatel...

journal_title：Progress in brain research

authors： Staiano W,Bosio A,de Morree HM,Rampinini E,Marcora S

更新日期：2018-01-01 00:00:00

abstract：:Hand preference is a sensorimotor skill whose development both reflects and promotes the development of hemispheric lateralization for manual and cognitive functions. Extensive comparative, crosscultural, and paleoanthropological evidence demonstrates the prevalence of limb lateralized preferences across vertebrate sp...

journal_title：Progress in brain research

authors： Michel GF,Babik I,Nelson EL,Campbell JM,Marcinowski EC

更新日期：2018-01-01 00:00:00

abstract：:Normal-tension glaucoma (NTG) is generally defined as visual field loss and optic nerve defects consistent with glaucoma and an intraocular pressure (IOP) that does not exceed 21 mmHg (Allingham, R.R., Damji, K., Freedman, S., Moroi, S., Shafranov, G., Shields, M.B. (2005). In: Pine J. and Murphy J. (Eds.), Shields' T...

journal_title：Progress in brain research

authors： Desai PV,Caprioli J

更新日期：2008-01-01 00:00:00

abstract：:This chapter has highlighted how correlates of neuronal plasticity such as electrophysiological responsiveness and changes in gene expression may be examined in defined CNS regions as well as in single cells. The ability to simultaneously measure the mRNA levels for hundreds of different genes, to clone novel genes, a...

journal_title：Progress in brain research

authors： Eberwine J,Cao Y,Nair S,Miyashiro K,Mackler S,Finnell R,Surmeier J,Dichter M

更新日期：1995-01-01 00:00:00

abstract：:In our overview, we will attempt to justify the use of animal models and suggest that it is the only way to make the successive transitions between changes occurring at the molecular and cellular levels and changes at the level of behaviour in the intact organism. We will also stress the importance of criteria that ha...

journal_title：Progress in brain research

authors： Castellucci VF

更新日期：2008-01-01 00:00:00

abstract：:Although visually responsive neurons predominate in the deep layers of the superior colliculus (SC), the majority of them also receive sensory inputs from nonvisual sources (i.e. auditory and/or somatosensory). Most of these 'multisensory' neurons are able to synthesize their cross-modal inputs and, as a consequence, ...

journal_title：Progress in brain research

authors： Stein BE,Jiang W,Wallace MT,Stanford TR

更新日期：2001-01-01 00:00:00

abstract：:Quantitative models of the oculomotor plant and control of the saccadic eye movement system are presented in this chapter. Oculomotor plant models described here are linear, including a second-order model by Westheimer (1954), Bahill et al. (1980) and Enderle et al. (2000). The model of the saccade generator is initia...

journal_title：Progress in brain research

authors： Enderle JD

更新日期：2002-01-01 00:00:00

abstract：:Research points to the notion that athletes have the potential to benefit from difficulty. This phenomenon-otherwise known as growth following adversity-has attracted increasing attention from sport psychology scholars. In this paper, we systematically review and synthesize the findings of studies in this area to bett...

journal_title：Progress in brain research

authors： Howells K,Sarkar M,Fletcher D

更新日期：2017-01-01 00:00:00

abstract：:Activated microglia release a number of substances, the specific cocktail released depending on the stimulus. Many of the substances released by microglia also serve to activate them, suggesting the presence of a number of autocrine/paracrine loops. Because of the low density of microglia present in the normal brain, ...

journal_title：Progress in brain research

authors： Pocock JM,Liddle AC

更新日期：2001-01-01 00:00:00