Abstract:
:X-linked Alport syndrome (XLAS) is a rare form of hereditary nephritis caused by mutations in the COL4A5 gene encoding the type IV collagen α5 chain. A skin biopsy was performed on one female patient with XLAS who carried a heterozygous p.G409S (c. 1225 G > A) mutation in the COL4A5 gene. A human-induced pluripotent stem cell (iPSC) line was generated from dermal fibroblasts using the integrating free Sendai virus technique. The generated iPSC line SHCDNRi001-A offers an efficient resource to research pathogenic mechanisms in XLAS, as well as a cell-based disease model for drug testing or other treatments.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Sun L,Zhang J,Kuang XY,Kang YL,Wu Y,Huang WYdoi
10.1016/j.scr.2020.101833subject
Has Abstractpub_date
2020-05-01 00:00:00pages
101833eissn
1873-5061issn
1876-7753pii
S1873-5061(20)30134-3journal_volume
45pub_type
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