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Generation of induced pluripotent stem cell line (XDCMHi001-A) from an Ankylosing spondylitis patient with JAK2 mutation.

Abstract：

:Heredity is the major factor contributing to the susceptibility to ankylosing spondylitis(AS). Janus kinase 2 (JAK2) has been associated with AS. Urine-derived cells from an AS patient with JAK2 mutation were used to generate induced pluripotent stem cells (iPSCs) with five episomal iPSC reprogramming vectors (pCXLE-hOCT3/4-shp53-F, pCXLE-hSK, pCXLE-hUL, pCXLE-EGFP and pCXWB-EBNA1). The iPSCs were pluripotent and will be valuable for research on the role and mechanism of JAK2 in the pathogenesis of AS.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Hu J,Ren W,Qiu W,Lv J,Zhang C,Xu C,DU W,Wu M,Wang J,Quan R

doi

10.1016/j.scr.2020.101788

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

101788

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(20)30091-X

journal_volume

45

pub_type

杂志文章

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