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Reprogramming of mouse amniotic fluid cells using a PiggyBac transposon system.

Abstract：

:Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by forced expression of defined transcription factors using different methods. Amniotic fluid (AF) cells are easy to obtain from routinely scheduled procedures for prenatal diagnosis and iPS cells have been generated from human AF. Here, we generated iPS cells from mouse AF cells, using a non-viral-based approach constituted by the PiggyBac (PB) transposon system. All iPS cell lines obtained exhibited characteristics of pluripotent cells, including the ability to differentiate toward derivatives of all three germ layers in vitro and in vivo.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Bertin E,Piccoli M,Franzin C,Nagy A,Mileikovsky M,De Coppi P,Pozzobon M

doi

10.1016/j.scr.2015.09.009

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

510-3

issue

3

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(15)00122-1

journal_volume

15

pub_type

杂志文章

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