Abstract:
:We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents. This iPS cell line showed typical embryonic stem cell-like morphology, expressed pluripotent markers that comparable to human embryonic stem cells. Moreover, these cells have the ability to differentiate into three germ layers and maintain a normal karyotype.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Sun C,Zhou P,Yuan S,Guo R,Zhang Z,Xu Q,Han D,He L,Tang H,Xu K,Hu H,Li Ndoi
10.1016/j.scr.2020.101783subject
Has Abstractpub_date
2020-05-01 00:00:00pages
101783eissn
1873-5061issn
1876-7753pii
S1873-5061(20)30086-6journal_volume
45pub_type
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