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Establishment of integration free iPSC clones, NCCSi011-A and NCCSi011-B from a liver cirrhosis patient of Indian origin with hepatic encephalopathy.

Abstract：

:Liver cirrhosis accompanied with hepatic encephalopathy commonly causes cognitive impairment in patients. To model this disease, two independent patient specific induced pluripotent stem cell-line (iPSC) clones, NCCSi011-A and NCCSi011-B were generated by reprogramming the CD4+ T cells of an Indian male patient suffering from this chronic condition. Both clones expressed the stemness markers, formed embryoid bodies (EBs) with potential for spontaneous differentiation in to all the three lineages, exhibited normal karyotype (46, XY) and demonstrated alkaline phosphatase activity. These generated iPSC lines have potential for use in understanding biology of the disease and evaluation of drugs.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Vaidyanath A,Khan M,Vaishnav B,Kakrani AL,Patil S,Shiras A

doi

10.1016/j.scr.2020.101992

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

101992

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(20)30293-2

journal_volume

48

pub_type

杂志文章

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