Abstract:
BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors. RESULTS:MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors. CONCLUSION:MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Jia W,Zhu J,Martin TA,Sanders AJ,Yang X,Cheng S,Yu H,Jia G,Liu X,Lu R,Jiang WGsubject
Has Abstractpub_date
2015-05-01 00:00:00pages
113-8issue
3eissn
1109-6535issn
1790-6245pii
12/3/113journal_volume
12pub_type
杂志文章abstract::Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2016-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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更新日期:2016-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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更新日期:2009-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2017-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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doi:
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更新日期:2011-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2020-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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