abstract：BACKGROUND/AIM:In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD (2/4), which allows the maintenance of chromatin integrity and plasticity....

journal_title：Cancer genomics & proteomics

authors： Idrissou M,Boisnier T,Sanchez A,Khoufaf FZH,Penault-Llorca F,Bignon YJ,Bernard-Gallon D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wn...

journal_title：Cancer genomics & proteomics

authors： Yeo MK,Bae GE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...

journal_title：Cancer genomics & proteomics

authors： Jasek-Gajda E,Jurkowska H,JasiŃska M,Litwin JA,Lis GJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...

journal_title：Cancer genomics & proteomics

authors： Moreno-Acosta P,Molano M,Morales N,Acosta J,GonzÁlez-Prieto C,Mayorga D,Buitrago L,Gamboa O,MejÍa JC,Castro J,Romero-Rojas A,Espenel S,Murray GL,Garland SM,Vallard A,MagnÉ N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precisio...

journal_title：Cancer genomics & proteomics

authors： Igarashi K,Kawaguchi K,Kiyuna T,Miyake K,Higuchi T,Yamamoto N,Hayashi K,Kimura H,Miwa S,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients. PATIENTS AND METHODS:The candidate germline variants between tumor relapse an...

journal_title：Cancer genomics & proteomics

authors： Huang KC,Chiang SF,Ke TW,Chen WT,Chen TW,Chao KC

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...

journal_title：Cancer genomics & proteomics

authors： Pei JS,Chang WS,Hsu PC,Chen CC,Chin YT,Huang TL,Hsu YN,Kuo CC,Wang YC,Tsai CW,Gong CL,Bau DT

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Johannsdottir IMR,Andersen K,Holth A,Beiske K,Heim S

更新日期：2020-01-01 00:00:00

abstract：:Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical an...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Nopora A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:The outcome of patients with advanced hepatocellular carcinoma (HCC) remains poor and therapeutic options, including sorafenib, the first anti-cancer drug proved to prolong survival in patients with advanced HCC, are limited. However, no clinically useful predictive biomarker for sorafenib has been repor...

journal_title：Cancer genomics & proteomics

authors： Feng YH,Tung CL,Su YC,Tsao CJ,Wu TF

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS:R...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Lobmaier I,Gorunova L,Heim S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:PTEN-loss and PIK3CA mutations have been addressed as markers of PI3K activation in breast cancer. We evaluated these markers in early high-risk breast cancer (EBC) focusing on PTEN immunohistochemistry (IHC) issues, particularly in HER2-positive disease. MATERIALS AND METHODS:We examined PTEN-loss and ...

journal_title：Cancer genomics & proteomics

authors： Lazaridis G,Kotoula V,Vrettou E,Kostopoulos I,Manousou K,Papadopoulou K,Giannoulatou E,Bobos M,Sotiropoulou M,Pentheroudakis G,Efstratiou I,Papoudou-Bai A,Psyrri A,Christodoulou C,Gogas H,Koutras A,Timotheadou E,Pectasi

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Pul-down assay is a popular in vitro method for identification of physical interactors of selected proteins. Here, for the first time, we compared three conventional variants of pull-down assay with the streptavidin-modified surface plasmon resonance (SPR) chips for the detection of PDZ and LIM domain pr...

journal_title：Cancer genomics & proteomics

authors： Maryáš J,Faktor J,Čápková L,Müller P,Skládal P,Bouchal P

更新日期：2018-09-01 00:00:00

abstract：:Sepantronium bromide (YM-155) is believed to elicit apoptosis and mitotic arrest in tumor cells by reducing (BIRC5, survivin) mRNA. In this study, we monitored changes in survivin mRNA and protein after treating MDA-MB-231 cells with YM-155 concurrent with evaluation of whole transcriptomic (WT) mRNA and long intergen...

journal_title：Cancer genomics & proteomics

authors： Mazzio EA,Lewis CA,Elhag R,Soliman KF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Fusion genes driving tumourigenesis have drawn the attention of researchers and oncologists. Despite the importance of such molecular alterations, there are no comprehensive reproducible methods for detecting fusion genes. MATERIALS AND METHODS:Nineteen paediatric brain tumours of five types, namely pilocyt...

journal_title：Cancer genomics & proteomics

authors： Kondo A,Shimizu Y,Adachi S,Ogino I,Suzuki M,Akiyama O,Arai H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Cowden syndrome (CS) is a rare autosomal-dominant inherited disorder characterized by multiple hamartomas. While the hamartomas are benign, patients with CS have increased risk of osteosarcoma and of breast, thyroid, endometrial, soft-tissue and colonic neoplasms. Germline mutations of phosphatase and tensin...

journal_title：Cancer genomics & proteomics

authors： Lopez C,Abuel-Haija M,Pena L,Coppola D

更新日期：2018-03-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...

journal_title：Cancer genomics & proteomics

authors： Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...

journal_title：Cancer genomics & proteomics

authors： Tsangaris GT,Dimas K,Malamou A,Katsafadou A,Papathanasiou C,Stravopodis DJ,Vorgias CE,Gazouli M,Anagnostopoulos AK

更新日期：2017-07-01 00:00:00

abstract：:The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be ...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Kollmorgen G,Rüger R

更新日期：2017-05-01 00:00:00

abstract：:Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell...

journal_title：Cancer genomics & proteomics

authors： Creaney J,Dick IM,Leon JS,Robinson BW

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Temozolomide-resistant (TMZ-R) glioblastoma is very difficult to treat, and a novel approach to overcome resistance is needed. MATERIALS AND METHODS:The efficacy of a combination treatment of STAT3 inhibitor, STX-0119, with rapamycin was investigated against our established TMZ-resistant U87 cell line. RES...

journal_title：Cancer genomics & proteomics

authors： Miyata H,Ashizawa T,Iizuka A,Kondou R,Nonomura C,Sugino T,Urakami K,Asai A,Hayashi N,Mitsuya K,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2017-01-02 00:00:00

abstract：BACKGROUND:Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) ...

journal_title：Cancer genomics & proteomics

authors： Sumida T,Ishikawa A,Mori Y

更新日期：2016-07-01 00:00:00

abstract：:Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...

journal_title：Cancer genomics & proteomics

authors： Zografos E,Gazouli M,Tsangaris G,Marinos E

更新日期：2016-05-01 00:00:00

abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...

journal_title：Cancer genomics & proteomics

authors： Isobe K,Kakimoto A,Mikami T,Kaburaki K,Kobayashi H,Yoshizawa T,Makino T,Otsuka H,Sano GO,Sugino K,Sakamoto S,Takai Y,Tochigi N,Iyoda A,Homma S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...

journal_title：Cancer genomics & proteomics

authors： DAS MK,Andreassen R,Haugen TB,Furu K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). MATERIALS AND METHODS:CRC tissues (n=93) and adjacent norma...

journal_title：Cancer genomics & proteomics

authors： Li J,Ye L,Sun PH,Satherley L,Hargest R,Zhang Z,Jiang WG

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human...

journal_title：Cancer genomics & proteomics

authors： Jia W,Zhu J,Martin TA,Sanders AJ,Yang X,Cheng S,Yu H,Jia G,Liu X,Lu R,Jiang WG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...

journal_title：Cancer genomics & proteomics

authors： Krayzler E,Nagler RM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...

journal_title：Cancer genomics & proteomics

authors： Narayanan R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...

journal_title：Cancer genomics & proteomics

authors： Hsu CM,Chang WS,Hwang JJ,Wang JY,Hsiao YL,Tsai CW,Liu JC,Ying TH,Bau DT

更新日期：2014-11-01 00:00:00

abstract：:Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predictin...

journal_title：Cancer genomics & proteomics

authors： Scully OJ,Bay BH,Yip G,Yu Y

更新日期：2012-09-01 00:00:00

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00