Abstract:
BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparative genomic hybridization (CGH) and cytogenetics to investigate the chromosomal abnormalities with reference to malignant potential. As parameters for biological aggressiveness, mitotic counts, necrosis, lymph and blood vessel invasion, lymph node and organ metastasis and Ki-67 index were used. RESULTS:Using CGH analysis, chromosome 13q loss was observed in 4 cases, of which 3 were ATC cases and 1 was a TC case with aggressive features. All the cases without 13q loss showed no aggressive features. Upon immunohistochemical analysis, RB protein expression was detected regardless of the 13q status. CONCLUSION:The results of this study indicate that another tumor suppressor gene on 13q may be involved in the malignant potential in pulmonary carcinoids.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Inamura K,Furuta R,Satoh Y,Shirakawa T,Okumura S,Nakagawa K,Fujiwara M,Tsuchiya E,Ishikawa Ysubject
Has Abstractpub_date
2006-01-01 00:00:00pages
39-45issue
1eissn
1109-6535issn
1790-6245pii
3/1/39journal_volume
3pub_type
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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更新日期:2014-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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doi:
更新日期:2004-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2009-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20023
更新日期:2017-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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journal_title:Cancer genomics & proteomics
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更新日期:2015-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2015-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2018-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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更新日期:2018-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
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