Abstract：
:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond to different therapeutic agents. Bioinformatics is now at the forefront of the post-genomics era and is providing a number of tools with which to mine the large datasets produced by genome-wide analysis. Of particular importance is the emergence of techniques that give the ability to reveal the transcription regulatory networks that are active in the cell in response to environmental stimuli or disease states. Deciphering the transcription networks that function in malignant cells not only will provide the knowledge to understand how carcinomas progress, but would also allow the construction of useful therapeutic tools for their effective treatment. In this review the recent advances that have been made in functional genomics that allow microarray data to be more fully interpreted and reveal the transcription networks that have gone awry in transformed cells are described.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Roberts ML,Kottaridis SDsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
301-8issue
4eissn
1109-6535issn
1790-6245journal_volume
4pub_type
杂志文章abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20141
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND/AIM:The outcome of patients with advanced hepatocellular carcinoma (HCC) remains poor and therapeutic options, including sorafenib, the first anti-cancer drug proved to prolong survival in patients with advanced HCC, are limited. However, no clinically useful predictive biomarker for sorafenib has been repor...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20159
更新日期：2019-11-01 00:00:00
abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients. PATIENTS AND METHODS:The candidate germline variants between tumor relapse an...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20189
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparati...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章,评审
doi：10.21873/cgp.20060
更新日期：2017-11-01 00:00:00
abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章,评审
doi：10.21873/cgp.20062
更新日期：2018-01-01 00:00:00
abstract：:We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining ...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20010
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20208
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20166
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20023
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The transcription factor SOX2 controls gene expression during development and has roles in both neurogenesis and gliogenesis. MATERIALS AND METHODS:The current study utilized immunohistochemistry, immunofluorescence, molecular genetics (gene copy number analysis) and Western blotting to examine SOX2 express...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Cowden syndrome (CS) is a rare autosomal-dominant inherited disorder characterized by multiple hamartomas. While the hamartomas are benign, patients with CS have increased risk of osteosarcoma and of breast, thyroid, endometrial, soft-tissue and colonic neoplasms. Germline mutations of phosphatase and tensin...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20069
更新日期：2018-03-01 00:00:00
abstract：:Soft tissue sarcomas are rare, heterogeneous, mesenchymal tumors that have been poorly classified. The heterogeneity of these aggressive tumors has made consistent tumor grading difficult and accurately predicting the behavior of the tumor based on the histological subtype and grade has been challenging. Molecular pro...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Although several microscopic techniques are available for separation of small groups of cells from surrounding tissue, the high energy concentrated into a small area, the easy control of beam position and the lack of direct contact with the material to be dissected make lasers the best option for a large scale microdi...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND/AIM:In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD (2/4), which allows the maintenance of chromatin integrity and plasticity....
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：10.21873/cgp.20223
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Previous studies have suggested that galectin-3 expression was markedly elevated in papillary thyroid carcinoma compared to other thyroid diseases. In order to better understand this protein, galectin-3 from papillary thyroid carcinoma was partially purified by affinity chromatography on lactose-agarose. Proteins elut...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:TACC2 is a member of the transforming acidic coiled-coil-containing protein family and is associated with the centrosome-spindle apparatus during cell cycling. The TACC2 gene is expressed in various splice forms predominantly in postmitotic tissues, including heart, muscle, kidney, and brain. Recent work has shown tha...
journal_title：Cancer genomics & proteomics
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
