Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:PTEN-loss and PIK3CA mutations have been addressed as markers of PI3K activation in breast cancer. We evaluated these markers in early high-risk breast cancer (EBC) focusing on PTEN immunohistochemistry (IHC) issues, particularly in HER2-positive disease. MATERIALS AND METHODS:We examined PTEN-loss and ...

journal_title：Cancer genomics & proteomics

authors： Lazaridis G,Kotoula V,Vrettou E,Kostopoulos I,Manousou K,Papadopoulou K,Giannoulatou E,Bobos M,Sotiropoulou M,Pentheroudakis G,Efstratiou I,Papoudou-Bai A,Psyrri A,Christodoulou C,Gogas H,Koutras A,Timotheadou E,Pectasi

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Identification and characterization of genes that are relevant to pancreatic cancer remains a priority for developing detection and diagnostic tests and identifying targets for treatment. MATERIALS AND METHODS:In order to discover relevant genes, we developed a microarray composed of 5763 pancreas and pancr...

journal_title：Cancer genomics & proteomics

authors： Pogue-Geile KL,Mackey JA,George RD,Wood PG,Lee KKW,Moser AJ,Tillman DL,Lyons-Weiler J,Whitcomb DC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...

journal_title：Cancer genomics & proteomics

authors： Bolander A,Agnarsdóttir M,Strömberg S,Ponten F,Hesselius P,Uhlen M,Bergqvist M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...

journal_title：Cancer genomics & proteomics

authors： Moreno-Acosta P,Molano M,Morales N,Acosta J,GonzÁlez-Prieto C,Mayorga D,Buitrago L,Gamboa O,MejÍa JC,Castro J,Romero-Rojas A,Espenel S,Murray GL,Garland SM,Vallard A,MagnÉ N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS:R...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Lobmaier I,Gorunova L,Heim S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：:Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predictin...

journal_title：Cancer genomics & proteomics

authors： Scully OJ,Bay BH,Yip G,Yu Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human...

journal_title：Cancer genomics & proteomics

authors： Jia W,Zhu J,Martin TA,Sanders AJ,Yang X,Cheng S,Yu H,Jia G,Liu X,Lu R,Jiang WG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients. PATIENTS AND METHODS:The candidate germline variants between tumor relapse an...

journal_title：Cancer genomics & proteomics

authors： Huang KC,Chiang SF,Ke TW,Chen WT,Chen TW,Chao KC

更新日期：2020-05-01 00:00:00

abstract：:Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...

journal_title：Cancer genomics & proteomics

authors： Biermann K,Heukamp LC,Steger K,Zhou H,Franke FE,Sonnack V,Brehm R,Berg J,Bastian PJ,Muller SC,Wang-Eckert L,Buettner R

更新日期：2007-09-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...

journal_title：Cancer genomics & proteomics

authors： Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIM:In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD (2/4), which allows the maintenance of chromatin integrity and plasticity....

journal_title：Cancer genomics & proteomics

authors： Idrissou M,Boisnier T,Sanchez A,Khoufaf FZH,Penault-Llorca F,Bignon YJ,Bernard-Gallon D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...

journal_title：Cancer genomics & proteomics

authors： Krayzler E,Nagler RM

更新日期：2015-03-01 00:00:00

abstract：:Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore, we analyzed 36 factors with known or assumed relevance and found that 8 prot...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Koomägi R,Mattern J,Volm M

更新日期：2004-05-01 00:00:00

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Fusion genes driving tumourigenesis have drawn the attention of researchers and oncologists. Despite the importance of such molecular alterations, there are no comprehensive reproducible methods for detecting fusion genes. MATERIALS AND METHODS:Nineteen paediatric brain tumours of five types, namely pilocyt...

journal_title：Cancer genomics & proteomics

authors： Kondo A,Shimizu Y,Adachi S,Ogino I,Suzuki M,Akiyama O,Arai H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...

journal_title：Cancer genomics & proteomics

authors： Pei JS,Chang WS,Hsu PC,Chen CC,Chin YT,Huang TL,Hsu YN,Kuo CC,Wang YC,Tsai CW,Gong CL,Bau DT

更新日期：2020-03-01 00:00:00

abstract：:Sepantronium bromide (YM-155) is believed to elicit apoptosis and mitotic arrest in tumor cells by reducing (BIRC5, survivin) mRNA. In this study, we monitored changes in survivin mRNA and protein after treating MDA-MB-231 cells with YM-155 concurrent with evaluation of whole transcriptomic (WT) mRNA and long intergen...

journal_title：Cancer genomics & proteomics

authors： Mazzio EA,Lewis CA,Elhag R,Soliman KF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Cowden syndrome (CS) is a rare autosomal-dominant inherited disorder characterized by multiple hamartomas. While the hamartomas are benign, patients with CS have increased risk of osteosarcoma and of breast, thyroid, endometrial, soft-tissue and colonic neoplasms. Germline mutations of phosphatase and tensin...

journal_title：Cancer genomics & proteomics

authors： Lopez C,Abuel-Haija M,Pena L,Coppola D

更新日期：2018-03-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related to death in both men and women. Protein biomarkers for lung cancer were investigated using the expression of proteins from lung cancer cell line (A549) and compared with those of normal lung fibroblast cell line (MRC-5). Two-dimensional gel electrophoresis of A549 and...

journal_title：Cancer genomics & proteomics

authors： Rubporn A,Srisomsap C,Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Svasti J,Sangvanich P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Johannsdottir IMR,Andersen K,Holth A,Beiske K,Heim S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...

journal_title：Cancer genomics & proteomics

authors： Jasek-Gajda E,Jurkowska H,JasiŃska M,Litwin JA,Lis GJ

更新日期：2020-09-01 00:00:00

abstract：:Tumorigenesis of glioblastoma multiforme (GBM), the most aggressive primary intracranial neoplasm, is associated with aberrant PI3K/AKT/mTOR signaling. Inhibitors of mTOR, such as rapamycin (RAPA) or its analogs, have provided limited benefit. Here, we aim to decipher the signaling pathways involved in RAPA resistance...

journal_title：Cancer genomics & proteomics

authors： Albert L,Karsy M,Murali R,Jhanwar-Uniyal M

更新日期：2009-09-01 00:00:00