Breast cancer metastasis.

abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...

journal_title：Cancer genomics & proteomics

authors： Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...

journal_title：Cancer genomics & proteomics

authors： Moreno-Acosta P,Molano M,Morales N,Acosta J,GonzÁlez-Prieto C,Mayorga D,Buitrago L,Gamboa O,MejÍa JC,Castro J,Romero-Rojas A,Espenel S,Murray GL,Garland SM,Vallard A,MagnÉ N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS:R...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Lobmaier I,Gorunova L,Heim S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) ...

journal_title：Cancer genomics & proteomics

authors： Sumida T,Ishikawa A,Mori Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wn...

journal_title：Cancer genomics & proteomics

authors： Yeo MK,Bae GE

更新日期：2020-11-01 00:00:00

abstract：:In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatmen...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Miyachi H,Bartsch H

更新日期：2007-03-01 00:00:00

abstract：:Sepantronium bromide (YM-155) is believed to elicit apoptosis and mitotic arrest in tumor cells by reducing (BIRC5, survivin) mRNA. In this study, we monitored changes in survivin mRNA and protein after treating MDA-MB-231 cells with YM-155 concurrent with evaluation of whole transcriptomic (WT) mRNA and long intergen...

journal_title：Cancer genomics & proteomics

authors： Mazzio EA,Lewis CA,Elhag R,Soliman KF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human...

journal_title：Cancer genomics & proteomics

authors： Jia W,Zhu J,Martin TA,Sanders AJ,Yang X,Cheng S,Yu H,Jia G,Liu X,Lu R,Jiang WG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...

journal_title：Cancer genomics & proteomics

authors： DAS MK,Andreassen R,Haugen TB,Furu K

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have suggested that galectin-3 expression was markedly elevated in papillary thyroid carcinoma compared to other thyroid diseases. In order to better understand this protein, galectin-3 from papillary thyroid carcinoma was partially purified by affinity chromatography on lactose-agarose. Proteins elut...

journal_title：Cancer genomics & proteomics

authors： Sawangareetrakul P,Srisomsap C,Chokchaichamnankit D,Svasti J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...

journal_title：Cancer genomics & proteomics

authors： Narayanan R

更新日期：2015-01-01 00:00:00

abstract：:We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...

journal_title：Cancer genomics & proteomics

authors： Lee SC,Chan J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND/AIM:In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD (2/4), which allows the maintenance of chromatin integrity and plasticity....

journal_title：Cancer genomics & proteomics

authors： Idrissou M,Boisnier T,Sanchez A,Khoufaf FZH,Penault-Llorca F,Bignon YJ,Bernard-Gallon D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...

journal_title：Cancer genomics & proteomics

authors： Bozsik A,Kökény S,Olah E

更新日期：2007-01-01 00:00:00

abstract：:Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...

journal_title：Cancer genomics & proteomics

authors： Biermann K,Heukamp LC,Steger K,Zhou H,Franke FE,Sonnack V,Brehm R,Berg J,Bastian PJ,Muller SC,Wang-Eckert L,Buettner R

更新日期：2007-09-01 00:00:00

abstract：:Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...

journal_title：Cancer genomics & proteomics

authors： Zografos E,Gazouli M,Tsangaris G,Marinos E

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...

journal_title：Cancer genomics & proteomics

authors： Bolander A,Agnarsdóttir M,Strömberg S,Ponten F,Hesselius P,Uhlen M,Bergqvist M

更新日期：2008-11-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related to death in both men and women. Protein biomarkers for lung cancer were investigated using the expression of proteins from lung cancer cell line (A549) and compared with those of normal lung fibroblast cell line (MRC-5). Two-dimensional gel electrophoresis of A549 and...

journal_title：Cancer genomics & proteomics

authors： Rubporn A,Srisomsap C,Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Svasti J,Sangvanich P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Clinical observations indicate that tumour cells can acquire tolerance when an anticancer drug is administered repeatedly. In the present study, the gene expression in cisplatin-resistant cells was analysed to identify early changes in gene expression in the course of cisplatin exposure. MATERIALS AND METHO...

journal_title：Cancer genomics & proteomics

authors： Takazawa K,Tsuchiya H,Yoshimichi U,Kanazawa Y,Ii S,Tomita K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00

abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...

journal_title：Cancer genomics & proteomics

authors： Isobe K,Kakimoto A,Mikami T,Kaburaki K,Kobayashi H,Yoshizawa T,Makino T,Otsuka H,Sano GO,Sugino K,Sakamoto S,Takai Y,Tochigi N,Iyoda A,Homma S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Fusion genes driving tumourigenesis have drawn the attention of researchers and oncologists. Despite the importance of such molecular alterations, there are no comprehensive reproducible methods for detecting fusion genes. MATERIALS AND METHODS:Nineteen paediatric brain tumours of five types, namely pilocyt...

journal_title：Cancer genomics & proteomics

authors： Kondo A,Shimizu Y,Adachi S,Ogino I,Suzuki M,Akiyama O,Arai H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...

journal_title：Cancer genomics & proteomics

authors： Hsu CM,Chang WS,Hwang JJ,Wang JY,Hsiao YL,Tsai CW,Liu JC,Ying TH,Bau DT

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). MATERIALS AND METHODS:CRC tissues (n=93) and adjacent norma...

journal_title：Cancer genomics & proteomics

authors： Li J,Ye L,Sun PH,Satherley L,Hargest R,Zhang Z,Jiang WG

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:PTEN-loss and PIK3CA mutations have been addressed as markers of PI3K activation in breast cancer. We evaluated these markers in early high-risk breast cancer (EBC) focusing on PTEN immunohistochemistry (IHC) issues, particularly in HER2-positive disease. MATERIALS AND METHODS:We examined PTEN-loss and ...

journal_title：Cancer genomics & proteomics

authors： Lazaridis G,Kotoula V,Vrettou E,Kostopoulos I,Manousou K,Papadopoulou K,Giannoulatou E,Bobos M,Sotiropoulou M,Pentheroudakis G,Efstratiou I,Papoudou-Bai A,Psyrri A,Christodoulou C,Gogas H,Koutras A,Timotheadou E,Pectasi

更新日期：2019-05-01 00:00:00