Proteomic Analysis Reveals Aberrant O-GlcNAcylation of Extracellular Proteins from Breast Cancer Cell Secretion.

abstract：:The expression profiles of the erythropoietin producing hepatocellular carcinoma (Eph) receptor family of tyrosine kinases have been previously shown to provide molecular signatures of normal breast cells, breast tumor cells and invasive breast carcinoma cells. In particular, the expression of EphB6 receptor is lost i...

journal_title：Cancer genomics & proteomics

authors： Kandpal RP

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human...

journal_title：Cancer genomics & proteomics

authors： Jia W,Zhu J,Martin TA,Sanders AJ,Yang X,Cheng S,Yu H,Jia G,Liu X,Lu R,Jiang WG

更新日期：2015-05-01 00:00:00

abstract：:Cellular signal transduction pathways and gene expression are tightly regulated to accommodate changes in response to physiological environments. In the current study, molecules were identified that are activated as a result of intracellular signaling and immediately expressed as mRNA in MCF-7 breast cancer cells shor...

journal_title：Cancer genomics & proteomics

authors： Nagashima T,Oyama M,Kozuka-Hata H,Yumoto N,Sakaki Y,Hatakeyama M

更新日期：2008-05-01 00:00:00

abstract：:Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell...

journal_title：Cancer genomics & proteomics

authors： Creaney J,Dick IM,Leon JS,Robinson BW

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The transcription factor SOX2 controls gene expression during development and has roles in both neurogenesis and gliogenesis. MATERIALS AND METHODS:The current study utilized immunohistochemistry, immunofluorescence, molecular genetics (gene copy number analysis) and Western blotting to examine SOX2 express...

journal_title：Cancer genomics & proteomics

authors： Annovazzi L,Mellai M,Caldera V,Valente G,Schiffer D

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Breast cancer metastasis is associated with the motility and invasiveness of breast cancer cells. In a previous study we reported the motility enhancement effect of keratinocyte growth factor (KGF) on breast cancer cells. This study established and characterized the influence of KGF on breast cancer cell mot...

journal_title：Cancer genomics & proteomics

authors： Zang XP,Lerner ML,DO SV,Brackett DJ,Pento JT

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：:Soft tissue sarcomas are rare, heterogeneous, mesenchymal tumors that have been poorly classified. The heterogeneity of these aggressive tumors has made consistent tumor grading difficult and accurately predicting the behavior of the tumor based on the histological subtype and grade has been challenging. Molecular pro...

journal_title：Cancer genomics & proteomics

authors： Caldwell RL,Holt GE,Caprioli RM

更新日期：2005-11-01 00:00:00

abstract：:Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical an...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Nopora A

更新日期：2019-11-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond ...

journal_title：Cancer genomics & proteomics

authors： Roberts ML,Kottaridis SD

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...

journal_title：Cancer genomics & proteomics

authors： Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

更新日期：2017-11-01 00:00:00

abstract：:The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be ...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Kollmorgen G,Rüger R

更新日期：2017-05-01 00:00:00

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Cowden syndrome (CS) is a rare autosomal-dominant inherited disorder characterized by multiple hamartomas. While the hamartomas are benign, patients with CS have increased risk of osteosarcoma and of breast, thyroid, endometrial, soft-tissue and colonic neoplasms. Germline mutations of phosphatase and tensin...

journal_title：Cancer genomics & proteomics

authors： Lopez C,Abuel-Haija M,Pena L,Coppola D

更新日期：2018-03-01 00:00:00

abstract：AIM:To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses. MATERIALS AND METHODS:microRNAs associated with glioblastoma survival within and across race, gender, recurrence,...

journal_title：Cancer genomics & proteomics

authors： Delfino KR,Serão NV,Southey BR,Rodriguez-Zas SL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...

journal_title：Cancer genomics & proteomics

authors： Bozsik A,Kökény S,Olah E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Johannsdottir IMR,Andersen K,Holth A,Beiske K,Heim S

更新日期：2020-01-01 00:00:00

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...

journal_title：Cancer genomics & proteomics

authors： Isobe K,Kakimoto A,Mikami T,Kaburaki K,Kobayashi H,Yoshizawa T,Makino T,Otsuka H,Sano GO,Sugino K,Sakamoto S,Takai Y,Tochigi N,Iyoda A,Homma S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...

journal_title：Cancer genomics & proteomics

authors： DAS MK,Andreassen R,Haugen TB,Furu K

更新日期：2016-01-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：:Although several microscopic techniques are available for separation of small groups of cells from surrounding tissue, the high energy concentrated into a small area, the easy control of beam position and the lack of direct contact with the material to be dissected make lasers the best option for a large scale microdi...

journal_title：Cancer genomics & proteomics

authors： Ahmed FE

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:PTEN-loss and PIK3CA mutations have been addressed as markers of PI3K activation in breast cancer. We evaluated these markers in early high-risk breast cancer (EBC) focusing on PTEN immunohistochemistry (IHC) issues, particularly in HER2-positive disease. MATERIALS AND METHODS:We examined PTEN-loss and ...

journal_title：Cancer genomics & proteomics

authors： Lazaridis G,Kotoula V,Vrettou E,Kostopoulos I,Manousou K,Papadopoulou K,Giannoulatou E,Bobos M,Sotiropoulou M,Pentheroudakis G,Efstratiou I,Papoudou-Bai A,Psyrri A,Christodoulou C,Gogas H,Koutras A,Timotheadou E,Pectasi

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...

journal_title：Cancer genomics & proteomics

authors： Tsangaris GT,Dimas K,Malamou A,Katsafadou A,Papathanasiou C,Stravopodis DJ,Vorgias CE,Gazouli M,Anagnostopoulos AK

更新日期：2017-07-01 00:00:00

abstract：:Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore, we analyzed 36 factors with known or assumed relevance and found that 8 prot...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Koomägi R,Mattern J,Volm M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparati...

journal_title：Cancer genomics & proteomics

authors： Inamura K,Furuta R,Satoh Y,Shirakawa T,Okumura S,Nakagawa K,Fujiwara M,Tsuchiya E,Ishikawa Y

更新日期：2006-01-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00