Abstract:
:Lung cancer is the leading cause of cancer-related to death in both men and women. Protein biomarkers for lung cancer were investigated using the expression of proteins from lung cancer cell line (A549) and compared with those of normal lung fibroblast cell line (MRC-5). Two-dimensional gel electrophoresis of A549 and MRC-5 cells was carried out and followed by protein identification using nanoelectrospray tandem mass spectrometry. Most proteins over expressed in A549 cells were phosphoproteins such as lamin AC 70 kDa, aldehyde dehydrogenase, alpha-enolase, glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase and peroxiredoxin. Moreover, some proteins were expressed only in A549 cells such as heterogeneous ribonucleoprotein A1, nuclear corepressor KAP1, transketolase and cytokeratin 18. Furthermore, the phosphoprotein chaperonin 60 was highly expressed in A549 cells. It is known to function in protein interactions and protein conformation. The over expression of this protein in cells may result in abnormalities of protein conformation and lead to early stage cancer. These proteins may be used as biomarker of lung cancer for early detection and clinical prognosis.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Rubporn A,Srisomsap C,Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Svasti J,Sangvanich Psubject
Has Abstractpub_date
2009-07-01 00:00:00pages
229-37issue
4eissn
1109-6535issn
1790-6245pii
6/4/229journal_volume
6pub_type
杂志文章abstract::Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2016-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2020-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2018-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
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journal_title:Cancer genomics & proteomics
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更新日期:2011-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2014-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:10.21873/cgp.20062
更新日期:2018-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20037
更新日期:2017-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20125
更新日期:2019-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:10.21873/cgp.20149
更新日期:2019-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20093
更新日期:2018-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
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doi:
更新日期:2008-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
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doi:10.21873/cgp.20023
更新日期:2017-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2007-05-01 00:00:00