Long Non-coding RNAs and their Role in Metastasis.

abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...

journal_title：Cancer genomics & proteomics

authors： DAS MK,Andreassen R,Haugen TB,Furu K

更新日期：2016-01-01 00:00:00

abstract：:We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining ...

journal_title：Cancer genomics & proteomics

authors： Costa LT,Thalhammer S,Heckl WM

更新日期：2004-01-01 00:00:00

abstract：:Although several microscopic techniques are available for separation of small groups of cells from surrounding tissue, the high energy concentrated into a small area, the easy control of beam position and the lack of direct contact with the material to be dissected make lasers the best option for a large scale microdi...

journal_title：Cancer genomics & proteomics

authors： Ahmed FE

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...

journal_title：Cancer genomics & proteomics

authors： Narayanan R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Temozolomide-resistant (TMZ-R) glioblastoma is very difficult to treat, and a novel approach to overcome resistance is needed. MATERIALS AND METHODS:The efficacy of a combination treatment of STAT3 inhibitor, STX-0119, with rapamycin was investigated against our established TMZ-resistant U87 cell line. RES...

journal_title：Cancer genomics & proteomics

authors： Miyata H,Ashizawa T,Iizuka A,Kondou R,Nonomura C,Sugino T,Urakami K,Asai A,Hayashi N,Mitsuya K,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2017-01-02 00:00:00

abstract：:Previous studies have suggested that galectin-3 expression was markedly elevated in papillary thyroid carcinoma compared to other thyroid diseases. In order to better understand this protein, galectin-3 from papillary thyroid carcinoma was partially purified by affinity chromatography on lactose-agarose. Proteins elut...

journal_title：Cancer genomics & proteomics

authors： Sawangareetrakul P,Srisomsap C,Chokchaichamnankit D,Svasti J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...

journal_title：Cancer genomics & proteomics

authors： Bozsik A,Kökény S,Olah E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients. PATIENTS AND METHODS:The candidate germline variants between tumor relapse an...

journal_title：Cancer genomics & proteomics

authors： Huang KC,Chiang SF,Ke TW,Chen WT,Chen TW,Chao KC

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) ...

journal_title：Cancer genomics & proteomics

authors： Sumida T,Ishikawa A,Mori Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Clinical observations indicate that tumour cells can acquire tolerance when an anticancer drug is administered repeatedly. In the present study, the gene expression in cisplatin-resistant cells was analysed to identify early changes in gene expression in the course of cisplatin exposure. MATERIALS AND METHO...

journal_title：Cancer genomics & proteomics

authors： Takazawa K,Tsuchiya H,Yoshimichi U,Kanazawa Y,Ii S,Tomita K

更新日期：2006-11-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...

journal_title：Cancer genomics & proteomics

authors： Tsangaris GT,Dimas K,Malamou A,Katsafadou A,Papathanasiou C,Stravopodis DJ,Vorgias CE,Gazouli M,Anagnostopoulos AK

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...

journal_title：Cancer genomics & proteomics

authors： Hsu CM,Chang WS,Hwang JJ,Wang JY,Hsiao YL,Tsai CW,Liu JC,Ying TH,Bau DT

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparati...

journal_title：Cancer genomics & proteomics

authors： Inamura K,Furuta R,Satoh Y,Shirakawa T,Okumura S,Nakagawa K,Fujiwara M,Tsuchiya E,Ishikawa Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS:R...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Lobmaier I,Gorunova L,Heim S

更新日期：2019-07-01 00:00:00

abstract：:Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell...

journal_title：Cancer genomics & proteomics

authors： Creaney J,Dick IM,Leon JS,Robinson BW

更新日期：2017-03-01 00:00:00

abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...

journal_title：Cancer genomics & proteomics

authors： Liu J,Liu YG,Huang R,Yao C,Li S,Yang W,Yang D,Huang RP

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:The outcome of patients with advanced hepatocellular carcinoma (HCC) remains poor and therapeutic options, including sorafenib, the first anti-cancer drug proved to prolong survival in patients with advanced HCC, are limited. However, no clinically useful predictive biomarker for sorafenib has been repor...

journal_title：Cancer genomics & proteomics

authors： Feng YH,Tung CL,Su YC,Tsao CJ,Wu TF

更新日期：2019-11-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND/AIM:Pul-down assay is a popular in vitro method for identification of physical interactors of selected proteins. Here, for the first time, we compared three conventional variants of pull-down assay with the streptavidin-modified surface plasmon resonance (SPR) chips for the detection of PDZ and LIM domain pr...

journal_title：Cancer genomics & proteomics

authors： Maryáš J,Faktor J,Čápková L,Müller P,Skládal P,Bouchal P

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...

journal_title：Cancer genomics & proteomics

authors： Pei JS,Chang WS,Hsu PC,Chen CC,Chin YT,Huang TL,Hsu YN,Kuo CC,Wang YC,Tsai CW,Gong CL,Bau DT

更新日期：2020-03-01 00:00:00

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：:We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...

journal_title：Cancer genomics & proteomics

authors： Lee SC,Chan J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00