High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases.

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：:TACC2 is a member of the transforming acidic coiled-coil-containing protein family and is associated with the centrosome-spindle apparatus during cell cycling. The TACC2 gene is expressed in various splice forms predominantly in postmitotic tissues, including heart, muscle, kidney, and brain. Recent work has shown tha...

journal_title：Cancer genomics & proteomics

authors： Cheng S,Douglas-Jones A,Yang X,Mansel RE,Jiang WG

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：:We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining ...

journal_title：Cancer genomics & proteomics

authors： Costa LT,Thalhammer S,Heckl WM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...

journal_title：Cancer genomics & proteomics

authors： Moreno-Acosta P,Molano M,Morales N,Acosta J,GonzÁlez-Prieto C,Mayorga D,Buitrago L,Gamboa O,MejÍa JC,Castro J,Romero-Rojas A,Espenel S,Murray GL,Garland SM,Vallard A,MagnÉ N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Breast cancer metastasis is associated with the motility and invasiveness of breast cancer cells. In a previous study we reported the motility enhancement effect of keratinocyte growth factor (KGF) on breast cancer cells. This study established and characterized the influence of KGF on breast cancer cell mot...

journal_title：Cancer genomics & proteomics

authors： Zang XP,Lerner ML,DO SV,Brackett DJ,Pento JT

更新日期：2004-07-01 00:00:00

abstract：:Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predictin...

journal_title：Cancer genomics & proteomics

authors： Scully OJ,Bay BH,Yip G,Yu Y

更新日期：2012-09-01 00:00:00

abstract：:Soft tissue sarcomas are rare, heterogeneous, mesenchymal tumors that have been poorly classified. The heterogeneity of these aggressive tumors has made consistent tumor grading difficult and accurately predicting the behavior of the tumor based on the histological subtype and grade has been challenging. Molecular pro...

journal_title：Cancer genomics & proteomics

authors： Caldwell RL,Holt GE,Caprioli RM

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：:Although the statistical probability of therapeutic success is known for larger groups of cancer patients, the clinical response to chemotherapy of the individual patient remains uncertain. It would be of great value to know whether or not an individual tumor responds to the proposed therapy. The concept of sensitivit...

journal_title：Cancer genomics & proteomics

authors： Volm M,Koomagi R,Efferth T

更新日期：2004-03-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). MATERIALS AND METHODS:CRC tissues (n=93) and adjacent norma...

journal_title：Cancer genomics & proteomics

authors： Li J,Ye L,Sun PH,Satherley L,Hargest R,Zhang Z,Jiang WG

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...

journal_title：Cancer genomics & proteomics

authors： Jasek-Gajda E,Jurkowska H,JasiŃska M,Litwin JA,Lis GJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...

journal_title：Cancer genomics & proteomics

authors： Izbicka E,Campos D,Carrizales G,Tolcher A

更新日期：2005-07-01 00:00:00

abstract：:In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatmen...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Miyachi H,Bartsch H

更新日期：2007-03-01 00:00:00

abstract：:Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical an...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Nopora A

更新日期：2019-11-01 00:00:00

abstract：:We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...

journal_title：Cancer genomics & proteomics

authors： Lee SC,Chan J

更新日期：2012-03-01 00:00:00

abstract：:Although several microscopic techniques are available for separation of small groups of cells from surrounding tissue, the high energy concentrated into a small area, the easy control of beam position and the lack of direct contact with the material to be dissected make lasers the best option for a large scale microdi...

journal_title：Cancer genomics & proteomics

authors： Ahmed FE

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precisio...

journal_title：Cancer genomics & proteomics

authors： Igarashi K,Kawaguchi K,Kiyuna T,Miyake K,Higuchi T,Yamamoto N,Hayashi K,Kimura H,Miwa S,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-07-01 00:00:00

abstract：:Sepantronium bromide (YM-155) is believed to elicit apoptosis and mitotic arrest in tumor cells by reducing (BIRC5, survivin) mRNA. In this study, we monitored changes in survivin mRNA and protein after treating MDA-MB-231 cells with YM-155 concurrent with evaluation of whole transcriptomic (WT) mRNA and long intergen...

journal_title：Cancer genomics & proteomics

authors： Mazzio EA,Lewis CA,Elhag R,Soliman KF

更新日期：2018-07-01 00:00:00

abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...

journal_title：Cancer genomics & proteomics

authors： Isobe K,Kakimoto A,Mikami T,Kaburaki K,Kobayashi H,Yoshizawa T,Makino T,Otsuka H,Sano GO,Sugino K,Sakamoto S,Takai Y,Tochigi N,Iyoda A,Homma S

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have suggested that galectin-3 expression was markedly elevated in papillary thyroid carcinoma compared to other thyroid diseases. In order to better understand this protein, galectin-3 from papillary thyroid carcinoma was partially purified by affinity chromatography on lactose-agarose. Proteins elut...

journal_title：Cancer genomics & proteomics

authors： Sawangareetrakul P,Srisomsap C,Chokchaichamnankit D,Svasti J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...

journal_title：Cancer genomics & proteomics

authors： Hsu CM,Chang WS,Hwang JJ,Wang JY,Hsiao YL,Tsai CW,Liu JC,Ying TH,Bau DT

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIM:Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS:R...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Lobmaier I,Gorunova L,Heim S

更新日期：2019-07-01 00:00:00

abstract：AIM:To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses. MATERIALS AND METHODS:microRNAs associated with glioblastoma survival within and across race, gender, recurrence,...

journal_title：Cancer genomics & proteomics

authors： Delfino KR,Serão NV,Southey BR,Rodriguez-Zas SL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Johannsdottir IMR,Andersen K,Holth A,Beiske K,Heim S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00