Abstract:
:Although the statistical probability of therapeutic success is known for larger groups of cancer patients, the clinical response to chemotherapy of the individual patient remains uncertain. It would be of great value to know whether or not an individual tumor responds to the proposed therapy. The concept of sensitivity testing of tumors for individualized therapy traces back to the 1970s. Currently, an astonishing revival has taken place due to the thriving development of genomic and proteomic technologies. This review discusses our own results on protein expression profiles of non-small cell lung cancer, kidney carcinoma and acute lymphoblastic leukemia regarding the prediction of drug sensitivity or resistance. A great diversity of drug resistance mechanisms are operative in the clinical drug resistance of cancer e.g., resistance proteins, proliferative, apoptotic, angiogenic factors, proto-oncogenes and tumor suppressor-genes. Hierarchical cluster analyses and cluster image maps reveal different resistance profiles even within cancer types of homogeneous histology. Protein arrays may be appropriate to perform sensitivity or resistance tests for individual patients because thousands of proteins may be detected in a single experiment. On the other hand, results suggest that already a set of a limited number of factors may be sufficient to detect the sensitivity or resistance of a cancer.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Volm M,Koomagi R,Efferth Tsubject
Has Abstractpub_date
2004-03-01 00:00:00pages
157-166issue
2eissn
1109-6535issn
1790-6245pii
1/2/157journal_volume
1pub_type
杂志文章,评审abstract:BACKGROUND/AIM:Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precisio...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20194
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20166
更新日期:2020-01-01 00:00:00
abstract::The expression profiles of the erythropoietin producing hepatocellular carcinoma (Eph) receptor family of tyrosine kinases have been previously shown to provide molecular signatures of normal breast cells, breast tumor cells and invasive breast carcinoma cells. In particular, the expression of EphB6 receptor is lost i...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Temozolomide-resistant (TMZ-R) glioblastoma is very difficult to treat, and a novel approach to overcome resistance is needed. MATERIALS AND METHODS:The efficacy of a combination treatment of STAT3 inhibitor, STX-0119, with rapamycin was investigated against our established TMZ-resistant U87 cell line. RES...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20021
更新日期:2017-01-02 00:00:00
abstract:BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20076
更新日期:2018-05-01 00:00:00
abstract::Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20105
更新日期:2018-11-01 00:00:00
abstract::We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining ...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract::The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be ...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:10.21873/cgp.20027
更新日期:2017-05-01 00:00:00
abstract::As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
abstract::The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20112
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20043
更新日期:2017-09-01 00:00:00
abstract::Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20208
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. MATERIALS AND METHODS:In the present study, we evaluated the expression levels of MTA1 in a cohort of human...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-05-01 00:00:00
abstract::After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20037
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Identification and characterization of genes that are relevant to pancreatic cancer remains a priority for developing detection and diagnostic tests and identifying targets for treatment. MATERIALS AND METHODS:In order to discover relevant genes, we developed a microarray composed of 5763 pancreas and pancr...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20178
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparati...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:10.21873/cgp.20060
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20218
更新日期:2020-09-01 00:00:00
abstract::Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract::Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20023
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract:UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00