Keratinocyte Growth Factor-Mediated Pattern of Gene Expression in Breast Cancer Cells.

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：:Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...

journal_title：Cancer genomics & proteomics

authors： Zografos E,Gazouli M,Tsangaris G,Marinos E

更新日期：2016-05-01 00:00:00

abstract：:Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore, we analyzed 36 factors with known or assumed relevance and found that 8 prot...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Koomägi R,Mattern J,Volm M

更新日期：2004-05-01 00:00:00

abstract：:The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be ...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Kollmorgen G,Rüger R

更新日期：2017-05-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...

journal_title：Cancer genomics & proteomics

authors： Tsangaris GT,Dimas K,Malamou A,Katsafadou A,Papathanasiou C,Stravopodis DJ,Vorgias CE,Gazouli M,Anagnostopoulos AK

更新日期：2017-07-01 00:00:00

abstract：:The concept of individualized cancer chemotherapy emerged three decades ago from the observation that a small fraction of cells in primary tumors can form colonies in soft agar similar to stem cells of the hematopoietic system. In a series of retrospective and prospective clinical studies, clonogenic tumor growth and ...

journal_title：Cancer genomics & proteomics

authors： Chumsri S,Phatak P,Edelman MJ,Khakpour N,Hamburger AW,Burger AM

更新日期：2007-05-01 00:00:00

abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...

journal_title：Cancer genomics & proteomics

authors： Liu J,Liu YG,Huang R,Yao C,Li S,Yang W,Yang D,Huang RP

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:Pul-down assay is a popular in vitro method for identification of physical interactors of selected proteins. Here, for the first time, we compared three conventional variants of pull-down assay with the streptavidin-modified surface plasmon resonance (SPR) chips for the detection of PDZ and LIM domain pr...

journal_title：Cancer genomics & proteomics

authors： Maryáš J,Faktor J,Čápková L,Müller P,Skládal P,Bouchal P

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...

journal_title：Cancer genomics & proteomics

authors： Pei JS,Chang WS,Hsu PC,Chen CC,Chin YT,Huang TL,Hsu YN,Kuo CC,Wang YC,Tsai CW,Gong CL,Bau DT

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:The outcome of patients with advanced hepatocellular carcinoma (HCC) remains poor and therapeutic options, including sorafenib, the first anti-cancer drug proved to prolong survival in patients with advanced HCC, are limited. However, no clinically useful predictive biomarker for sorafenib has been repor...

journal_title：Cancer genomics & proteomics

authors： Feng YH,Tung CL,Su YC,Tsao CJ,Wu TF

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) ...

journal_title：Cancer genomics & proteomics

authors： Sumida T,Ishikawa A,Mori Y

更新日期：2016-07-01 00:00:00

abstract：:TACC2 is a member of the transforming acidic coiled-coil-containing protein family and is associated with the centrosome-spindle apparatus during cell cycling. The TACC2 gene is expressed in various splice forms predominantly in postmitotic tissues, including heart, muscle, kidney, and brain. Recent work has shown tha...

journal_title：Cancer genomics & proteomics

authors： Cheng S,Douglas-Jones A,Yang X,Mansel RE,Jiang WG

更新日期：2010-03-01 00:00:00

abstract：AIM:To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses. MATERIALS AND METHODS:microRNAs associated with glioblastoma survival within and across race, gender, recurrence,...

journal_title：Cancer genomics & proteomics

authors： Delfino KR,Serão NV,Southey BR,Rodriguez-Zas SL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. MATERIALS AND METHODS:The MSI status was determined by polymerase chain reaction (PCR) using 5 mononucleotide and 13 CAn dinucleotide repeats. RESULTS:None of the...

journal_title：Cancer genomics & proteomics

authors： Goumard C,Desbois-Mouthon C,Wendum D,Calmel C,Merabtene F,Scatton O,Praz F

更新日期：2017-09-01 00:00:00

abstract：:Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...

journal_title：Cancer genomics & proteomics

authors： Biermann K,Heukamp LC,Steger K,Zhou H,Franke FE,Sonnack V,Brehm R,Berg J,Bastian PJ,Muller SC,Wang-Eckert L,Buettner R

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...

journal_title：Cancer genomics & proteomics

authors： Bolander A,Agnarsdóttir M,Strömberg S,Ponten F,Hesselius P,Uhlen M,Bergqvist M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND/AIM:Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. PATIENTS AND ...

journal_title：Cancer genomics & proteomics

authors： Wilson BD,Ricks-Santi LJ,Mason TE,Abbas M,Kittles RA,Dunston GM,Kanaan YM

更新日期：2018-05-01 00:00:00

abstract：:Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical an...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Nopora A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS...

journal_title：Cancer genomics & proteomics

authors： Hsu CM,Chang WS,Hwang JJ,Wang JY,Hsiao YL,Tsai CW,Liu JC,Ying TH,Bau DT

更新日期：2014-11-01 00:00:00

abstract：:Although the statistical probability of therapeutic success is known for larger groups of cancer patients, the clinical response to chemotherapy of the individual patient remains uncertain. It would be of great value to know whether or not an individual tumor responds to the proposed therapy. The concept of sensitivit...

journal_title：Cancer genomics & proteomics

authors： Volm M,Koomagi R,Efferth T

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...

journal_title：Cancer genomics & proteomics

authors： Jasek-Gajda E,Jurkowska H,JasiŃska M,Litwin JA,Lis GJ

更新日期：2020-09-01 00:00:00

abstract：:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond ...

journal_title：Cancer genomics & proteomics

authors： Roberts ML,Kottaridis SD

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...

journal_title：Cancer genomics & proteomics

authors： Narayanan R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00

abstract：:Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predictin...

journal_title：Cancer genomics & proteomics

authors： Scully OJ,Bay BH,Yip G,Yu Y

更新日期：2012-09-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00