Abstract:
AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The aim of this study was to evaluate the association of polymorphic genotypes of CRYAB with breast cancer within a Taiwanese population. PATIENTS AND METHODS:In this hospital-based study, 1232 patients with breast cancer and an equal number of healthy controls in central Taiwan were genotyped via polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) and the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron 2 (rs2070894) polymorphisms with breast cancer risk in a central Taiwanese population was investigated. RESULTS:Those individuals with CRYAB C-802G CG and GG genotypes had 1.50- and 2.22-fold risk for breast cancer than those with the CC genotype. As for the A-1215G and intron 2 polymorphisms, there was no significant association of the genotype with breast cancer risk. In allelic frequency analysis, the G allele CRYAB C-802G conferred a significantly (p=5.63×10(-10)) increased risk of breast cancer. Our results provide evidence that the G allele of CRYAB C-802G is correlated with breast cancer risk and this polymorphism may be a useful marker for early detection of breast cancer in clinical practice.
journal_name
Cancer Genomics Proteomicsjournal_title
Cancer genomics & proteomicsauthors
Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DTsubject
Has Abstractpub_date
2011-09-01 00:00:00pages
251-4issue
5eissn
1109-6535issn
1790-6245pii
8/5/251journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wn...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20233
更新日期:2020-11-01 00:00:00
abstract::We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...
journal_title:Cancer genomics & proteomics
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更新日期:2012-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20189
更新日期:2020-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2006-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20076
更新日期:2018-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2011-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2005-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2011-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2016-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20159
更新日期:2019-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2019-05-01 00:00:00
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journal_title:Cancer genomics & proteomics
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更新日期:2007-09-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::The expression profiles of the erythropoietin producing hepatocellular carcinoma (Eph) receptor family of tyrosine kinases have been previously shown to provide molecular signatures of normal breast cells, breast tumor cells and invasive breast carcinoma cells. In particular, the expression of EphB6 receptor is lost i...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...
journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章
doi:10.21873/cgp.20093
更新日期:2018-07-01 00:00:00
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journal_title:Cancer genomics & proteomics
pub_type: 杂志文章,评审
doi:
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