A New Microarray, Enriched in Pancreas and Pancreatic Cancer cDNAs to Identify Genes Relevant to Pancreatic Cancer.

abstract：:In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatmen...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Miyachi H,Bartsch H

更新日期：2007-03-01 00:00:00

abstract：:As shown previously doxorubicin (1 μM) plus sulindac (50 μM) reduced the expression of ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) mRNA in HeLa cells and this effect was accompanied by increased apoptosis. The aim of this study was to define if the decrease of ABCB1 expression or blocking of P-glyco...

journal_title：Cancer genomics & proteomics

authors： Gruber BM,Krzysztoń-Russjan J,Bubko I,Koronkiewicz M,Anuszewska EL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:O-GlcNAcylation is a unique intracellular protein modification; however, few extracellular O-GlcNAc-modified proteins have been discovered. We have previously demonstrated that many cellular proteins were aberrant in O-GlcNAcylation in breast cancer tissues. In the present study, therefore, we investigated w...

journal_title：Cancer genomics & proteomics

authors： Netsirisawan P,Chokchaichamnankit D,Srisomsap C,Svasti J,Champattanachai V

更新日期：2015-07-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS:The National Center for Biotechnology Information (NCBI) Phenome Genome In...

journal_title：Cancer genomics & proteomics

authors： Narayanan R

更新日期：2015-01-01 00:00:00

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：:The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be ...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Kollmorgen G,Rüger R

更新日期：2017-05-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIM:Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precisio...

journal_title：Cancer genomics & proteomics

authors： Igarashi K,Kawaguchi K,Kiyuna T,Miyake K,Higuchi T,Yamamoto N,Hayashi K,Kimura H,Miwa S,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). MATERIALS AND METHODS:CRC tissues (n=93) and adjacent norma...

journal_title：Cancer genomics & proteomics

authors： Li J,Ye L,Sun PH,Satherley L,Hargest R,Zhang Z,Jiang WG

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old fem...

journal_title：Cancer genomics & proteomics

authors： Tsangaris GT,Dimas K,Malamou A,Katsafadou A,Papathanasiou C,Stravopodis DJ,Vorgias CE,Gazouli M,Anagnostopoulos AK

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could...

journal_title：Cancer genomics & proteomics

authors： Lehrer S,Rheinstein PH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...

journal_title：Cancer genomics & proteomics

authors： Krayzler E,Nagler RM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wn...

journal_title：Cancer genomics & proteomics

authors： Yeo MK,Bae GE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND/AIM:Pul-down assay is a popular in vitro method for identification of physical interactors of selected proteins. Here, for the first time, we compared three conventional variants of pull-down assay with the streptavidin-modified surface plasmon resonance (SPR) chips for the detection of PDZ and LIM domain pr...

journal_title：Cancer genomics & proteomics

authors： Maryáš J,Faktor J,Čápková L,Müller P,Skládal P,Bouchal P

更新日期：2018-09-01 00:00:00

abstract：AIM:This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ)...

journal_title：Cancer genomics & proteomics

authors： Isobe K,Kakimoto A,Mikami T,Kaburaki K,Kobayashi H,Yoshizawa T,Makino T,Otsuka H,Sano GO,Sugino K,Sakamoto S,Takai Y,Tochigi N,Iyoda A,Homma S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The transcription factor SOX2 controls gene expression during development and has roles in both neurogenesis and gliogenesis. MATERIALS AND METHODS:The current study utilized immunohistochemistry, immunofluorescence, molecular genetics (gene copy number analysis) and Western blotting to examine SOX2 express...

journal_title：Cancer genomics & proteomics

authors： Annovazzi L,Mellai M,Caldera V,Valente G,Schiffer D

更新日期：2011-05-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Fusion genes driving tumourigenesis have drawn the attention of researchers and oncologists. Despite the importance of such molecular alterations, there are no comprehensive reproducible methods for detecting fusion genes. MATERIALS AND METHODS:Nineteen paediatric brain tumours of five types, namely pilocyt...

journal_title：Cancer genomics & proteomics

authors： Kondo A,Shimizu Y,Adachi S,Ogino I,Suzuki M,Akiyama O,Arai H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Clinical observations indicate that tumour cells can acquire tolerance when an anticancer drug is administered repeatedly. In the present study, the gene expression in cisplatin-resistant cells was analysed to identify early changes in gene expression in the course of cisplatin exposure. MATERIALS AND METHO...

journal_title：Cancer genomics & proteomics

authors： Takazawa K,Tsuchiya H,Yoshimichi U,Kanazawa Y,Ii S,Tomita K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIM:The outcome of patients with advanced hepatocellular carcinoma (HCC) remains poor and therapeutic options, including sorafenib, the first anti-cancer drug proved to prolong survival in patients with advanced HCC, are limited. However, no clinically useful predictive biomarker for sorafenib has been repor...

journal_title：Cancer genomics & proteomics

authors： Feng YH,Tung CL,Su YC,Tsao CJ,Wu TF

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients. PATIENTS AND METHODS:The candidate germline variants between tumor relapse an...

journal_title：Cancer genomics & proteomics

authors： Huang KC,Chiang SF,Ke TW,Chen WT,Chen TW,Chao KC

更新日期：2020-05-01 00:00:00

abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...

journal_title：Cancer genomics & proteomics

authors： Liu J,Liu YG,Huang R,Yao C,Li S,Yang W,Yang D,Huang RP

更新日期：2007-11-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS:One hundred seventy-three patients ...

journal_title：Cancer genomics & proteomics

authors： Moreno-Acosta P,Molano M,Morales N,Acosta J,GonzÁlez-Prieto C,Mayorga D,Buitrago L,Gamboa O,MejÍa JC,Castro J,Romero-Rojas A,Espenel S,Murray GL,Garland SM,Vallard A,MagnÉ N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00

abstract：:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond ...

journal_title：Cancer genomics & proteomics

authors： Roberts ML,Kottaridis SD

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...

journal_title：Cancer genomics & proteomics

authors： Izbicka E,Campos D,Carrizales G,Tolcher A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Temozolomide-resistant (TMZ-R) glioblastoma is very difficult to treat, and a novel approach to overcome resistance is needed. MATERIALS AND METHODS:The efficacy of a combination treatment of STAT3 inhibitor, STX-0119, with rapamycin was investigated against our established TMZ-resistant U87 cell line. RES...

journal_title：Cancer genomics & proteomics

authors： Miyata H,Ashizawa T,Iizuka A,Kondou R,Nonomura C,Sugino T,Urakami K,Asai A,Hayashi N,Mitsuya K,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2017-01-02 00:00:00