Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line.

abstract：:Cellular signal transduction pathways and gene expression are tightly regulated to accommodate changes in response to physiological environments. In the current study, molecules were identified that are activated as a result of intracellular signaling and immediately expressed as mRNA in MCF-7 breast cancer cells shor...

journal_title：Cancer genomics & proteomics

authors： Nagashima T,Oyama M,Kozuka-Hata H,Yumoto N,Sakaki Y,Hatakeyama M

更新日期：2008-05-01 00:00:00

abstract：:We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...

journal_title：Cancer genomics & proteomics

authors： Lee SC,Chan J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...

journal_title：Cancer genomics & proteomics

authors： Bozsik A,Kökény S,Olah E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wn...

journal_title：Cancer genomics & proteomics

authors： Yeo MK,Bae GE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Oncogenic infection by HPV, eventually leads to cervical carcinogenesis, associated by deregulation of specific pathways and protein expression at the intracellular and secretome level. Thus, secretome analysis can elucidate the biological mechanisms contributing to cervical cancer. In the present study we s...

journal_title：Cancer genomics & proteomics

authors： Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIM:Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several soli...

journal_title：Cancer genomics & proteomics

authors： Pei JS,Chang WS,Hsu PC,Chen CC,Chin YT,Huang TL,Hsu YN,Kuo CC,Wang YC,Tsai CW,Gong CL,Bau DT

更新日期：2020-03-01 00:00:00

abstract：:Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predictin...

journal_title：Cancer genomics & proteomics

authors： Scully OJ,Bay BH,Yip G,Yu Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly performed in vitro in human cancer cell lines using quantitative polymerase chain reaction (qPCR),...

journal_title：Cancer genomics & proteomics

authors： DAS MK,Andreassen R,Haugen TB,Furu K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...

journal_title：Cancer genomics & proteomics

authors： Izbicka E,Campos D,Carrizales G,Tolcher A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. MATERIALS AND METHODS:A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization ...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Johannsdottir IMR,Andersen K,Holth A,Beiske K,Heim S

更新日期：2020-01-01 00:00:00

abstract：:TACC2 is a member of the transforming acidic coiled-coil-containing protein family and is associated with the centrosome-spindle apparatus during cell cycling. The TACC2 gene is expressed in various splice forms predominantly in postmitotic tissues, including heart, muscle, kidney, and brain. Recent work has shown tha...

journal_title：Cancer genomics & proteomics

authors： Cheng S,Douglas-Jones A,Yang X,Mansel RE,Jiang WG

更新日期：2010-03-01 00:00:00

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond ...

journal_title：Cancer genomics & proteomics

authors： Roberts ML,Kottaridis SD

更新日期：2007-07-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the...

journal_title：Cancer genomics & proteomics

authors： Christodoulou C,Oikonomopoulos G,Koliou GA,Kostopoulos I,Kotoula V,Bobos M,Pentheroudakis G,Lazaridis G,Skondra M,Chrisafi S,Koutras A,Bafaloukos D,Razis E,Papadopoulou K,Papakostas P,Kalofonos HP,Pectasides D,Skarlos P

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times. MATERIALS AND METHODS:We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated...

journal_title：Cancer genomics & proteomics

authors： Krayzler E,Nagler RM

更新日期：2015-03-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：:Soft tissue sarcomas are rare, heterogeneous, mesenchymal tumors that have been poorly classified. The heterogeneity of these aggressive tumors has made consistent tumor grading difficult and accurately predicting the behavior of the tumor based on the histological subtype and grade has been challenging. Molecular pro...

journal_title：Cancer genomics & proteomics

authors： Caldwell RL,Holt GE,Caprioli RM

更新日期：2005-11-01 00:00:00

abstract：AIM:To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses. MATERIALS AND METHODS:microRNAs associated with glioblastoma survival within and across race, gender, recurrence,...

journal_title：Cancer genomics & proteomics

authors： Delfino KR,Serão NV,Southey BR,Rodriguez-Zas SL

更新日期：2011-07-01 00:00:00

abstract：:Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore, we analyzed 36 factors with known or assumed relevance and found that 8 prot...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Koomägi R,Mattern J,Volm M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic tar...

journal_title：Cancer genomics & proteomics

authors： Jasek-Gajda E,Jurkowska H,JasiŃska M,Litwin JA,Lis GJ

更新日期：2020-09-01 00:00:00

abstract：:In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatmen...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Miyachi H,Bartsch H

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health problem worldwide, and the number of incident cases increases every year expected to reach 17.1 million a year by 2020. There is evidence that people who adhere to the Mediterranean Diet (MediD) have lower incidence of cancer. However, cancers' location and culture studies see...

journal_title：Cancer genomics & proteomics

authors： Barak Y,Fridman D

更新日期：2017-11-01 00:00:00

abstract：:Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importa...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Dickopf S,Hintermair C,Kollmorgen G,Birzele F,Brinkmann U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. MATERIALS AND METHODS:Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were perf...

journal_title：Cancer genomics & proteomics

authors： Panagopoulos I,Gorunova L,Lobmaier I,Lund-Iversen M,Andersen K,Holth A,Bjerkehagen B,Heim S

更新日期：2019-09-01 00:00:00

abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...

journal_title：Cancer genomics & proteomics

authors： Liu J,Liu YG,Huang R,Yao C,Li S,Yang W,Yang D,Huang RP

更新日期：2007-11-01 00:00:00

abstract：:Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical an...

journal_title：Cancer genomics & proteomics

authors： Weidle UH,Birzele F,Nopora A

更新日期：2019-11-01 00:00:00

abstract：:Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by i...

journal_title：Cancer genomics & proteomics

authors： Zografos E,Gazouli M,Tsangaris G,Marinos E

更新日期：2016-05-01 00:00:00

abstract：:The concept of individualized cancer chemotherapy emerged three decades ago from the observation that a small fraction of cells in primary tumors can form colonies in soft agar similar to stem cells of the hematopoietic system. In a series of retrospective and prospective clinical studies, clonogenic tumor growth and ...

journal_title：Cancer genomics & proteomics

authors： Chumsri S,Phatak P,Edelman MJ,Khakpour N,Hamburger AW,Burger AM

更新日期：2007-05-01 00:00:00

abstract：:The expression profiles of the erythropoietin producing hepatocellular carcinoma (Eph) receptor family of tyrosine kinases have been previously shown to provide molecular signatures of normal breast cells, breast tumor cells and invasive breast carcinoma cells. In particular, the expression of EphB6 receptor is lost i...

journal_title：Cancer genomics & proteomics

authors： Kandpal RP

更新日期：2010-09-01 00:00:00