Abstract：
:Maneb, an organomanganese fungicide, is largely used in agricultural regions for control of field crop pathologies. Despite its apparent low toxicity, there are reports showing that maneb has harmful effects on peripheral and central nervous systems. In this work the effects of acute administration of maneb were studied on some experimental animal models. Male adult mice were treated with several doses of maneb, IP, and submitted to gross behavioral observation (200-1000 mg/kg) and measurement of locomotor activity, barbiturate-induced sleeping time, isolation-induced aggressiveness, catatonia, climbing behavior and of rota-rod performance (30, 60 and 100 mg/kg). The results showed that maneb has an inhibitory effect on locomotor activity and aggressiveness and increases barbiturate-induced sleeping time and haloperidol-induced catatonia. However, maneb did not affect the apomorphine-induced climbing behavior of animals. These data indicate that maneb has a CNS depressant-like effect, and suggest, at least partially, the involvement of dopaminergic systems in the mediation of this effect.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Morato GS,Lemos T,Takahashi RNdoi
10.1016/0892-0362(89)90018-4subject
Has Abstractpub_date
1989-09-01 00:00:00pages
421-5issue
5eissn
0892-0362issn
1872-9738journal_volume
11pub_type
杂志文章abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2006.10.001
更新日期：2007-03-01 00:00:00
abstract：UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2006.07.004
更新日期：2006-11-01 00:00:00
abstract：:In the literature on the effects of early exposure to neurotoxic agents on infant and child development, considerable attention has been devoted to two important issues--ascertainment of exposure and spurious correlation. In this paper, we review these research challenges and focus on three additional issues that, in ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2005.01.009
更新日期：2005-05-01 00:00:00
abstract：:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant locat...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(01)00163-5
更新日期：2001-09-01 00:00:00
abstract：:Evidence is presented showing that serial choice reaction performance is disrupted at low blood lead levels (PbB), and that parametric variation of task characteristics modulates the degree of disruption. This evidence is based on two independent studies in 6- to 9-year-old children living in two lead smelter areas in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90043-3
更新日期：1989-11-01 00:00:00
abstract：:The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SI...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2003.07.018
更新日期：2003-11-01 00:00:00
abstract：:In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.08.008
更新日期：2012-01-01 00:00:00
abstract：:Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90067-0
更新日期：1988-01-01 00:00:00
abstract：:Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. Male Long-Evans rats were implanted with electrodes in the amygdala or dorsal dentate gyrus, and injected IP daily with 40 mg/kg CDF,...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90021-9
更新日期：1988-05-01 00:00:00
abstract：:Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(87)90035-3
更新日期：1987-09-01 00:00:00
abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.10.002
更新日期：2005-01-01 00:00:00
abstract：:Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(03)00029-1
更新日期：2003-07-01 00:00:00
abstract：:Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00094-9
更新日期：1998-07-01 00:00:00
abstract：:Computer competition analysis of 3H-DHA (3H-dihydroalprenolol, a nonselective beta-adrenergic radioligand) binding in the presence of unlabeled metoprolol (a beta 1-selective antagonist) indicates the existence of both beta 1- and beta 2-adrenergic receptor subtypes in the rat placenta and confirms previous reports th...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90026-s
更新日期：1991-01-01 00:00:00
abstract：:The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as many of the effects, particularly during development, are unknown. The effects of these drugs upon homeostasis may be important since both are known to stimulate the hy...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.08.012
更新日期：2010-03-01 00:00:00
abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90027-2
更新日期：1994-07-01 00:00:00
abstract：:During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90009-4
更新日期：1994-01-01 00:00:00
abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/S0892-0362(03)00093-X
更新日期：2004-01-01 00:00:00
abstract：:The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behav...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(02)00204-0
更新日期：2002-03-01 00:00:00
abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.05.006
更新日期：2011-07-01 00:00:00
abstract：:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(00)00067-2
更新日期：2000-07-01 00:00:00
abstract：:Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethano...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00093-7
更新日期：1998-05-01 00:00:00
abstract：:We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90015-o
更新日期：1991-03-01 00:00:00
abstract：:The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.02.001
更新日期：2014-03-01 00:00:00
abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2020.106916
更新日期：2020-01-01 00:00:00
abstract：:Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.10.006
更新日期：2011-03-01 00:00:00
abstract：:Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(01)00193-3
更新日期：2002-01-01 00:00:00
abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90073-1
更新日期：1989-05-01 00:00:00
abstract：:The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)90027-6
更新日期：1996-05-01 00:00:00
abstract：:Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2013.02.001
更新日期：2013-05-01 00:00:00
