Abstract:
:The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SIDS), and Tourette syndrome. These four cohorts were used to estimate prevalence and magnitude of effect of parental risk markers in patients with developmental disabilities. Cases with North Dakota birth certificates were matched with controls. Using birth certificate data, we then examined five parental risk markers for each cohort and estimated direct and indirect effects for each risk marker by cohort. The authors found two significant paternal risk markers (age in SIDS and education in FAS). Significant maternal markers were age in SIDS, education in FAS, autism, and SIDS. Marital status was a significant risk marker in FAS. Effect sizes were estimated using paired t tests, odds ratios, and population attributable risk (PAR) for both direct and indirect effects for each marker. We estimated both direct and indirect effects to allow for direct comparisons of the differential effect estimates of each of these markers. The direct effect of parental markers differs across diagnostic cohorts of patients. Use of cohorts from similar denominator populations obtained from prevalence studies is a useful methodological tool for estimating the prevalence and magnitude of effect of risk markers.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Klug MG,Burd L,Kerbeshian J,Benz B,Martsolf JTdoi
10.1016/j.ntt.2003.07.018subject
Has Abstractpub_date
2003-11-01 00:00:00pages
707-17issue
6eissn
0892-0362issn
1872-9738pii
S089203620300103Xjournal_volume
25pub_type
杂志文章abstract::Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a pr...
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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