Abstract:
:The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-κB activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Win-Shwe TT,Kunugita N,Yoshida Y,Fujimaki Hdoi
10.1016/j.ntt.2011.07.005subject
Has Abstractpub_date
2011-09-01 00:00:00pages
598-602issue
5eissn
0892-0362issn
1872-9738pii
S0892-0362(11)00154-1journal_volume
33pub_type
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