Combined effects of simultaneous exposure to toluene and ethanol on auditory function in rats.

abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...

journal_title：Neurotoxicology and teratology

authors： Yin HS,Tan HW

更新日期：2007-03-01 00:00:00

abstract：:Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. The treatment was continued in nursing mothers until postnatal day 7. All studies were performed in their offsprings on pos...

journal_title：Neurotoxicology and teratology

authors： Hseu SS,Yien HW,Du F,Sun LS

更新日期：1998-11-01 00:00:00

abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...

journal_title：Neurotoxicology and teratology

authors： Chen J,Chen Y,Liu W,Bai C,Liu X,Liu K,Li R,Zhu JH,Huang C

更新日期：2012-11-01 00:00:00

abstract：:Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...

journal_title：Neurotoxicology and teratology

authors： Ponchio RA,Teodorov E,Kirsten TB,Coelho CP,Oshiro A,Florio JC,Bernardi MM

更新日期：2015-07-01 00:00:00

abstract：:In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

journal_title：Neurotoxicology and teratology

authors： Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

更新日期：2012-01-01 00:00:00

abstract：:The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

journal_title：Neurotoxicology and teratology

authors： Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

更新日期：1995-05-01 00:00:00

abstract：:During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

journal_title：Neurotoxicology and teratology

authors： Lochry EA,Johnson C,Wier PJ

更新日期：1994-01-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00

abstract：:Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...

journal_title：Neurotoxicology and teratology

authors： Amador FC,Henriques AG,da Cruz E Silva OA,da Cruz E Silva EF

更新日期：2004-05-01 00:00:00

abstract：:Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...

journal_title：Neurotoxicology and teratology

authors： Powers CM,Levin ED,Seidler FJ,Slotkin TA

更新日期：2011-03-01 00:00:00

abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

journal_title：Neurotoxicology and teratology

authors： Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...

journal_title：Neurotoxicology and teratology

authors： Shoemaker RC,House D,Ryan JC

更新日期：2010-11-01 00:00:00

abstract：:Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following ...

journal_title：Neurotoxicology and teratology

authors： Nelson BK

更新日期：1990-07-01 00:00:00

abstract：:We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the striatum by MPTP. Following MPTP treatment, increased GFAP immunoreactivity reached a peak at 2 days and persisted for at least 6 weeks. Immunoreactivity to vimentin was also markedly increased in astrocytes 48 h...

journal_title：Neurotoxicology and teratology

authors： Francis JW,Von Visger J,Markelonis GJ,Oh TH

更新日期：1995-01-01 00:00:00

abstract：:The therapeutic use in the human teratogenic range of retinoid compounds (Accutane; Tigason) for the treatment of dermatologic disorders has refocused attention on the teratogenicity of vitamin A-related compounds. This article reviews rodent data on three retinoids: vitamin A (retinol), all-trans retinoic acid (treti...

journal_title：Neurotoxicology and teratology

authors： Adams J

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

journal_title：Neurotoxicology and teratology

authors： Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

更新日期：2007-05-01 00:00:00

abstract：:Long-Evans rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate and normal controls were trained in a two-choice box to discriminate between stimuli of different brightness (black vs. white) or pattern (horizontal vs. vertical alternating black-and-white stripes). Mild footshock was used...

journal_title：Neurotoxicology and teratology

authors： Rabe A,Lee MH

更新日期：1990-07-01 00:00:00

abstract：:Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...

journal_title：Neurotoxicology and teratology

authors： Hitchcock EM,Dick RB,Krieg EF

更新日期：2004-03-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW,Humphrey HE

更新日期：1990-07-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：:Ochratoxin A (a mycotoxin) is known to cause cell death in the developing brain of embryos 1-2 days after treatment. Microcephaly was observed with high frequency in mice by prenatal treatment with ochratoxin A. Using a stereological method, the numerical densities of neurons and synapses were investigated in the soma...

journal_title：Neurotoxicology and teratology

authors： Fukui Y,Hayasaka S,Itoh M,Takeuchi Y

更新日期：1992-05-01 00:00:00

abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

journal_title：Neurotoxicology and teratology

authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

更新日期：2014-05-01 00:00:00

abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

journal_title：Neurotoxicology and teratology

authors： Wolansky MJ,Azcurra JM

更新日期：2005-03-01 00:00:00

abstract：:In the literature on the effects of early exposure to neurotoxic agents on infant and child development, considerable attention has been devoted to two important issues--ascertainment of exposure and spurious correlation. In this paper, we review these research challenges and focus on three additional issues that, in ...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW

更新日期：2005-05-01 00:00:00

abstract：:A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....

journal_title：Neurotoxicology and teratology

authors： Paule MG,Green L,Myerson J,Alvarado M,Bachevalier J,Schneider JS,Schantz SL

更新日期：2012-03-01 00:00:00

abstract：:The postnatal behavioral effects of 0.20, 0.62 and 2.0 mg/kg cadmium chloride administered to pregnant CFY rats on gestational days 7 through 15 were evaluated. Offspring were tested starting on postnatal day 23 on a rotorod for motor coordination, in an open field device for motor activity and emotionality, in a wate...

journal_title：Neurotoxicology and teratology

authors： Lehotzky K,Ungváry G,Polinák D,Kiss A

更新日期：1990-03-01 00:00:00

abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....

journal_title：Neurotoxicology and teratology

authors： Howell LL,Schama KF,Ellis JE,Grimley PJ,Kitchens AJ,Byrd LD

更新日期：2001-03-01 00:00:00

abstract：:Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...

journal_title：Neurotoxicology and teratology

authors： Devi PU,Hossain M,Bisht KS

更新日期：1999-03-01 00:00:00

abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

journal_title：Neurotoxicology and teratology

authors： Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

更新日期：2005-01-01 00:00:00