Combined effects of simultaneous exposure to toluene and ethanol on auditory function in rats.

Abstract:

:Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethanol (4 g/kg, 4 weeks), and the last group was simultaneously exposed to both toluene and ethanol. Auditory function was tested by recording brain stem (inferior colliculus) auditory-evoked potentials for audiometric frequencies ranging from 2 to 32 kHz. Urinary hippuric acid was dosed to check the toluene metabolism during the experiments. Ethanol clearly modified the toluene metabolism in the present experimental conditions. As a result, the hearing loss induced by a simultaneous exposure to both ethanol and toluene was larger than that induced by exposure to toluene alone.

journal_name

Neurotoxicol Teratol

authors

Campo P,Lataye R,Cossec B,Villette V,Roure M,Barthelemy C

doi

10.1016/s0892-0362(97)00093-7

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

321-32

issue

3

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(97)00093-7

journal_volume

20

pub_type

杂志文章
  • Formamidine pesticides enhance susceptibility to kindled seizures in amygdala and hippocampus of the rat.

    abstract::Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. Male Long-Evans rats were implanted with electrodes in the amygdala or dorsal dentate gyrus, and injected IP daily with 40 mg/kg CDF,...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(88)90021-9

    authors: Gilbert ME

    更新日期:1988-05-01 00:00:00

  • Ethanol-induced cell death in cultured rat astroglia.

    abstract::Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(96)00226-7

    authors: Holownia A,Ledig M,Ménez JF

    更新日期:1997-03-01 00:00:00

  • Effects of acute treatment with dopaminergic drugs on open field behavior of adult monkeys treated with lead during the first year postpartum.

    abstract::A pharmacological challenge of nonhuman primate open field behavior, similar to that which previously assessed the cholinergic system (10), was used here to measure potential lead-induced alterations in the dopaminergic system. Monkeys that had been treated with lead during the first year postpartum were assessed at 7...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(95)02050-0

    authors: Ferguson SA,Felipa HN,Bowman RE

    更新日期:1996-03-01 00:00:00

  • Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene.

    abstract::Volatile organic solvent (inhalant) abuse continues to be a major health concern throughout the world. Of particular concern is the abuse of inhalants by adolescents because of its toxicity and link to illicit drug use. Toluene, which is found in many products such as glues and household cleaners, is among the most co...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2007.08.001

    authors: Bowen SE,Charlesworth JD,Tokarz ME,Wright MJ Jr,Wiley JL

    更新日期:2007-11-01 00:00:00

  • Thermoregulatory effects of chlorpyrifos in the rat: long-term changes in cholinergic and noradrenergic sensitivity.

    abstract::Subcutaneous injection of a sublethal dose of chlorpyrifos (CHLP), an organophosphate (OP) pesticide, causes long-term inhibition in cholinesterase activity (ChE) of brain, blood, and other tissues. Such prolonged inhibition in ChE should lead to marked behavioral and autonomic thermoregulatory patterns, especially in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)90002-7

    authors: Gordon CJ

    更新日期:1994-01-01 00:00:00

  • Repeated measures designs in behavioral toxicology: application to chronic marijuana smoke exposure.

    abstract::This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(90)90005-w

    authors: Allen RR,Slikker W Jr,Paule MG

    更新日期:1990-09-01 00:00:00

  • Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation.

    abstract:OBJECTIVE:A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported a significant association between early childhood Pb levels and cardiovascular response to acute stress. The current study considers the association betw...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2010.10.001

    authors: Gump BB,Mackenzie JA,Bendinskas K,Morgan R,Dumas AK,Palmer CD,Parsons PJ

    更新日期:2011-03-01 00:00:00

  • Monitoring protein phosphatase 1 isoform levels as a marker for cellular stress.

    abstract::Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2003.12.007

    authors: Amador FC,Henriques AG,da Cruz E Silva OA,da Cruz E Silva EF

    更新日期:2004-05-01 00:00:00

  • Sociodemographic factors modifying the effect of environmental lead on neuropsychological development in early childhood.

    abstract::A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(92)90038-c

    authors: McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

    更新日期:1992-09-01 00:00:00

  • Pyrethroid effects on schedule-controlled behavior: time and dosage relationships.

    abstract::Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(87)90035-3

    authors: Peele DB,Crofton KM

    更新日期:1987-09-01 00:00:00

  • N-methylation underlying Parkinson's disease.

    abstract::The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is maybe initiated or precipitated by environmental or endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. Endogenous analogs of MPTP, such as beta-c...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/s0892-0362(02)00212-x

    authors: Matsubara K,Aoyama K,Suno M,Awaya T

    更新日期:2002-09-01 00:00:00

  • Toluene ototoxicity in rats: assessment of the frequency of hearing deficit by electrocochleography.

    abstract::To identify the frequency range most sensitive to toluene-induced auditory damage, the auditory function of adult Long-Evans rats exposed to 1750 ppm of toluene (6 h/day, 5 days/week, 4 weeks), was tested by recording auditory-evoked potentials directly from the round window of the cochlea. The present electrocochleog...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(98)00057-9

    authors: Lataye R,Campo P,Loquet G

    更新日期:1999-05-01 00:00:00

  • Neuropsychological sequelae from acute poisoning and long-term exposure to carbamate and organophosphate pesticides.

    abstract:UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.07.004

    authors: Roldan-Tapia L,Nieto-Escamez FA,del Aguila EM,Laynez F,Parron T,Sanchez-Santed F

    更新日期:2006-11-01 00:00:00

  • Behavioral and monoaminergic changes after lindane exposure in developing rats.

    abstract::The effects of lindane on behavior and central monoaminergic systems were studied in rat pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO doses, either a single 20 mg/kg or 7-day repeated 10 mg/kg doses. Both treatment schedules improved the passive avoidance acquisition but only t...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(97)00079-2

    authors: Rivera S,Rosa R,Martínez E,Suñol C,Serrano MT,Vendrell M,Rodríguez-Farré E,Sanfeliu C

    更新日期:1998-03-01 00:00:00

  • Neurophysiological markers as early signs of organophosphate neurotoxicity.

    abstract::The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(88)90004-9

    authors: Nagymajtényi L,Dési I,Lorencz R

    更新日期:1988-09-01 00:00:00

  • Prenatal ethanol exposure in rats: long-lasting effects on learning.

    abstract::Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed under a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(95)00014-i

    authors: Clausing P,Ferguson SA,Holson RR,Allen RR,Paule MG

    更新日期:1995-09-01 00:00:00

  • Preweaning experience as a modifier of prenatal drug effects in rats and mice--a review.

    abstract::The effects of preweaning experience in rats and mice on neuroendocrine and behavioral end points and their implications for prenatal drug effects are reviewed. The hypothalamo-pituitary-adrenal axis and the dopaminergic system were shown to be affected. Behavior related to hippocampal, adrenocortical functions and to...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/s0892-0362(99)00051-3

    authors: Clausing P,Mothes HK,Opitz B

    更新日期:2000-01-01 00:00:00

  • Low-level prenatal exposure to nicotine and infant neurobehavior.

    abstract:OBJECTIVE:To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. STUDY DESIGN:Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobac...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2009.07.004

    authors: Yolton K,Khoury J,Xu Y,Succop P,Lanphear B,Bernert JT,Lester B

    更新日期:2009-11-01 00:00:00

  • Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and marihuana.

    abstract::Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00046-x

    authors: Fried PA,Watkinson B

    更新日期:2000-01-01 00:00:00

  • Adenosine deaminase activity and gene expression patterns are altered after chronic ethanol exposure in zebrafish brain.

    abstract::Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2017.11.001

    authors: Rico EP,Rosemberg DB,Berteli JFA,da Silveira Langoni A,Souto AA,Bogo MR,Bonan CD,Souza DO

    更新日期:2018-01-01 00:00:00

  • Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior.

    abstract::Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a pr...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ntt.2019.106834

    authors: Dow-Edwards D,MacMaster FP,Peterson BS,Niesink R,Andersen S,Braams BR

    更新日期:2019-01-01 00:00:00

  • Ventromedian forebrain dysgenesis follows early prenatal ethanol exposure in mice.

    abstract::Ethanol exposure on gestational day (GD) 7 in the mouse has previously been shown to result in ventromedian forebrain deficits along with facial anomalies characteristic of fetal alcohol syndrome (FAS). To further explore ethanol's teratogenic effect on the ventromedian forebrain in this mouse model, scanning electron...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2010.11.001

    authors: Godin EA,Dehart DB,Parnell SE,O'Leary-Moore SK,Sulik KK

    更新日期:2011-03-01 00:00:00

  • Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats.

    abstract::The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(97)00002-0

    authors: Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

    更新日期:1997-07-01 00:00:00

  • Long-term cognitive sequelae of solvent intoxication.

    abstract::Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0892-0362(96)00024-4

    authors: Stollery BT

    更新日期:1996-07-01 00:00:00

  • Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity.

    abstract::The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ntt.2016.10.007

    authors: Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

    更新日期:2017-01-01 00:00:00

  • Exacerbation of iminodipropionitrile-induced behavioral toxicity, oxidative stress, and vestibular hair cell degeneration by gentamicin in rats.

    abstract::This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00075-6

    authors: Al Deeb S,Al Moutaery K,Khan HA,Tariq M

    更新日期:2000-03-01 00:00:00

  • Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana.

    abstract::Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(03)00029-1

    authors: Fried PA,Watkinson B,Gray R

    更新日期:2003-07-01 00:00:00

  • A fostering/crossfostering analysis of the effects of prenatal ethanol exposure in a liquid diet on offspring development and behavior in rats.

    abstract::Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(89)90049-4

    authors: Vorhees CV

    更新日期:1989-03-01 00:00:00

  • Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C.

    abstract::Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.02.001

    authors: Slotkin TA,Seidler FJ,Spindel ER

    更新日期:2011-05-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.02.003

    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00