Abstract:
OBJECTIVE:A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported a significant association between early childhood Pb levels and cardiovascular response to acute stress. The current study considers the association between current Pb levels and the autonomic nervous system activation pattern underlying the cardiovascular response to stress in a new cohort of children. METHODS:We assessed blood Pb levels as well as cardiovascular responses to acute stress in 9-11 year old children (N=140). Sympathetic activation (measured with pre-ejection period) and parasympathetic activation (measured with high frequency heart rate variability) were also assessed. RESULTS:In a sample with very low levels of blood Pb (M=1.0 μg/dL), we found that increasing blood Pb was associated with coinhibition of sympathetic and parasympathetic activation in response to acute stress. In addition, increasing Pb levels were associated with the hemodynamic stress response pattern typical of coinhibition--significantly greater vascular resistance and reduced stroke volume and cardiac output. CONCLUSIONS:Blood Pb levels were associated with significant autonomic and cardiovascular dysregulation in response to acute psychological stress in children. Moreover, these effects were significant at Pb levels considered to be very low and notably well below the 10 μg/dL, the Centers for Disease Control and Prevention definition of an elevated blood Pb level. The potential for autonomic dysregulation at levels of Pb typical for many US children would suggest potentially broad public health ramifications.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Gump BB,Mackenzie JA,Bendinskas K,Morgan R,Dumas AK,Palmer CD,Parsons PJdoi
10.1016/j.ntt.2010.10.001subject
Has Abstractpub_date
2011-03-01 00:00:00pages
212-9issue
2eissn
0892-0362issn
1872-9738pii
S0892-0362(10)00170-4journal_volume
33pub_type
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