Effects of subdiaphragmatic vagotomy on the acquisition of a radiation-induced conditioned taste aversion.

abstract：:Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

journal_title：Neurotoxicology and teratology

authors： Foss JA,Riley EP

更新日期：1991-09-01 00:00:00

abstract：:Ethanol exposure on gestational day (GD) 7 in the mouse has previously been shown to result in ventromedian forebrain deficits along with facial anomalies characteristic of fetal alcohol syndrome (FAS). To further explore ethanol's teratogenic effect on the ventromedian forebrain in this mouse model, scanning electron...

journal_title：Neurotoxicology and teratology

authors： Godin EA,Dehart DB,Parnell SE,O'Leary-Moore SK,Sulik KK

更新日期：2011-03-01 00:00:00

abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

journal_title：Neurotoxicology and teratology

authors： Minnema DJ,Hammond PB

更新日期：1994-11-01 00:00:00

abstract：:Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...

journal_title：Neurotoxicology and teratology

authors： Devi PU,Hossain M,Bisht KS

更新日期：1999-03-01 00:00:00

abstract：:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

journal_title：Neurotoxicology and teratology

authors： Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

更新日期：1991-09-01 00:00:00

abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

journal_title：Neurotoxicology and teratology

authors： Dribben WH,Creeley CE,Farber N

更新日期：2011-07-01 00:00:00

abstract：:This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...

journal_title：Neurotoxicology and teratology

authors： Janulewicz PA,Killiany RJ,White RF,Martin BM,Winter MR,Weinberg JM,Aschengrau A

更新日期：2013-07-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...

journal_title：Neurotoxicology and teratology

authors： Parajuli RP,Fujiwara T,Umezaki M,Furusawa H,Watanabe C

更新日期：2014-01-01 00:00:00

abstract：:The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...

journal_title：Neurotoxicology and teratology

authors： Farr KL,Montano CY,Paxton LL,Savage DD

更新日期：1988-11-01 00:00:00

abstract：:The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...

journal_title：Neurotoxicology and teratology

authors： Cronise K,Kelly SJ

更新日期：2001-07-01 00:00:00

abstract：:The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. We established mechanistically-based complementary models for the study of cholinergic systems in...

journal_title：Neurotoxicology and teratology

authors： Yanai J,Brick-Turin Y,Dotan S,Langford R,Pinkas A,Slotkin TA

更新日期：2010-01-01 00:00:00

abstract：:We examined the distribution of cocaine and its metabolites benzoylecgonine (BE) and norcocaine (NOR) in pregnant Sprague-Dawley rats and fetuses following twice-daily subcutaneous (s.c.) injections of 20 mg/kg cocaine HCl from gestational day (GD) 8 through GD 20. On GD 21, the animals received a single injection and...

journal_title：Neurotoxicology and teratology

authors： Collins LM,Pahl JA,Meyer JS

更新日期：1999-11-01 00:00:00

abstract：:Amitraz is a formamidine pesticide that has been reported to be a neurotoxic compound that induces convulsions among other effects. Excitatory and inhibitory neurotransmission is mediated mainly by glutamate and GABA, respectively, so their alteration could be responsible for induction of seizures. In this regard, ami...

journal_title：Neurotoxicology and teratology

authors： Del Pino J,Frejo MT,Baselga MJ,Moyano P,Díaz MJ

更新日期：2015-07-01 00:00:00

abstract：:The incidence of Fetal Alcohol Syndrome is now estimated at 0.97 cases per 1,000 live births in the general obstetric population and 4.3% among "heavy" drinkers. The general incidence is more than 20 times higher in the United States (1.95 per 1,000) compared to Europe and other countries (0.08 per 1,000). Within the ...

journal_title：Neurotoxicology and teratology

authors： Abel EL

更新日期：1995-07-01 00:00:00

abstract：:Most epileptic women delivering children each year take anticonvulsants throughout pregnancy. The teratogenic potential of anticonvulsants is most notable for phenytoin, trimethadione, valproic acid, and carbamazepine. This review focuses on the human and animal evidence for the teratogenicity of phenytoin, with empha...

journal_title：Neurotoxicology and teratology

authors： Adams J,Vorhees CV,Middaugh LD

更新日期：1990-05-01 00:00:00

abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

journal_title：Neurotoxicology and teratology

authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

更新日期：2017-05-01 00:00:00

abstract：:Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...

journal_title：Neurotoxicology and teratology

authors： Bond NW

更新日期：1988-01-01 00:00:00

abstract：:Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

journal_title：Neurotoxicology and teratology

authors： Oliveri AN,Ortiz E,Levin ED

更新日期：2018-01-01 00:00:00

abstract：:A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

journal_title：Neurotoxicology and teratology

authors： Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

更新日期：1997-11-01 00:00:00

abstract：:With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

更新日期：2008-07-01 00:00:00

abstract：:Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on G...

journal_title：Neurotoxicology and teratology

authors： Cutler AR,Wilkerson AE,Gingras JL,Levin ED

更新日期：1996-11-01 00:00:00

abstract：:Previous studies have indicated that prenatal ethanol (EtOH) exposure alters developing catecholamine (CA) systems and acute sensitivity to the locomotor stimulant effects of EtOH. The purpose of this study was to examine whether prenatal EtOH exposure influences the effects of the direct dopamine (DA) agonist apomorp...

journal_title：Neurotoxicology and teratology

authors： Becker HC,Weathersby RT,Hale RL

更新日期：1995-01-01 00:00:00

abstract：:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant locat...

journal_title：Neurotoxicology and teratology

authors： Campagna D,Stengel B,Mergler D,Limasset JC,Diebold F,Michard D,Huel G

更新日期：2001-09-01 00:00:00

abstract：:Chemical warfare nerve agents (CWNAs) are known to cause behavioral abnormalities in cases of human exposures and in animal models. The behavioral consequences of single exposures to CWNAs that cause observable toxic signs are particularly well characterized in animals; however, less is known regarding repeated smalle...

journal_title：Neurotoxicology and teratology

authors： Smith CD,Lee RB,Moran AV,Sipos ML

更新日期：2016-03-01 00:00:00

abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

journal_title：Neurotoxicology and teratology

authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

更新日期：2014-05-01 00:00:00

abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

journal_title：Neurotoxicology and teratology

authors： Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

更新日期：2020-01-01 00:00:00

abstract：:This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...

journal_title：Neurotoxicology and teratology

authors： Allen RR,Slikker W Jr,Paule MG

更新日期：1990-09-01 00:00:00

abstract：:Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3...

journal_title：Neurotoxicology and teratology

authors： Fukumura M,Cappon GD,Broening HW,Vorhees CV

更新日期：1998-07-01 00:00:00

abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B

更新日期：2000-01-01 00:00:00