Abstract：
:Chemical warfare nerve agents (CWNAs) are known to cause behavioral abnormalities in cases of human exposures and in animal models. The behavioral consequences of single exposures to CWNAs that cause observable toxic signs are particularly well characterized in animals; however, less is known regarding repeated smaller exposures that may or may not cause observable toxic signs. In the current study, guinea pigs were exposed to fractions (0.1, 0.2, or 0.4) of a medial lethal dose (LD50) of sarin, soman, or VX for two weeks. On each exposure day, and for a post-exposure period, acoustic startle response (ASR) was measured in each animal. Although relatively few studies use guinea pigs to measure behavior, this species is ideal for CWNA-related experiments because their levels of carboxylesterases closely mimic those of humans, unlike rats or mice. Results showed that the 0.4 LD50 doses of soman and VX transiently increased peak startle amplitude by the second week of injections, with amplitude returning to baseline by the second week post-exposure. Sarin also increased peak startle amplitude independent of week. Latencies to peak startle and PPI were affected by agent exposure but not consistently among the three agents. Most of the changes in startle responses returned to baseline following the cessation of exposures. These data suggest that doses of CWNAs not known to produce observable toxic signs in guinea pigs can affect behavior in the ASR paradigm. Further, these deficits are transient and usually return to baseline shortly after the end of a two-week exposure period.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Smith CD,Lee RB,Moran AV,Sipos MLdoi
10.1016/j.ntt.2016.01.005subject
Has Abstractpub_date
2016-03-01 00:00:00pages
36-45eissn
0892-0362issn
1872-9738pii
S0892-0362(16)30005-8journal_volume
54pub_type
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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doi：10.1016/j.ntt.2006.06.006
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doi：10.1016/0892-0362(92)90029-a
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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