Effects of prenatal propofol exposure on postnatal development in rats.


:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2 h (2HP) on gestational day 18. An additional group (lipid) was assigned to receive continuous infusion of intralipid fat emulsion (vehicle of propofol) for 2 h. Pups were then tested on the appearance and progression of sensory and physical motor abilities between postnatal day 1 (P1) and P28. The brain and body weights of pups from 2HP group on P10 were significantly lower than those from the saline control group, although they were the same in all four groups at birth (P0). Pups from 1HP and 2HP groups, but not lipid group, showed slower maturation of eyes (delayed opening) and several neurological reflexes (hindlimb reflex, righting reflex); they also showed delayed improvement in execution on gait reflex and inclined board tests. The forelimb reflex and negative geotaxis were also delayed in 2HP group. All parameters examined except body weight of 2HP pups recovered to normal levels by P28. We conclude that administration of propofol to pregnant rats leads to retardation in physical and neurological reflex development in their offspring.


Neurotoxicol Teratol


Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A




Has Abstract


2014-05-01 00:00:00












  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride.

    abstract::Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mattsson JL,Albee RR,Eisenbrandt DL,Chang LW

    更新日期:1988-03-01 00:00:00

  • Ultrasonic calling in rodents: a new experimental approach in behavioural toxicology.

    abstract::Ultrasonic calls are emitted by many species of rodents in a variety of situations. In particular, infants commonly emit such calls when removed from the nest; the rate and intensity of calling are related to the degree of development of homoiothermy. The relevant biological significance of these signals is documented...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Cuomo V,De Salvia MA,Maselli MA,Santo L,Cagiano R

    更新日期:1987-03-01 00:00:00

  • 3-Nitropropionic acid produces indirect excitotoxic damage to rat striatum.

    abstract::The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

    更新日期:1995-05-01 00:00:00

  • Determining normal variability in a developmental neurotoxicity test: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.

    abstract::With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

    更新日期:2008-07-01 00:00:00

  • Preliminary findings of a reduction of otoconia in the inner ear of adult rats prenatally exposed to phenytoin.

    abstract::Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Minck DR,Erway LC,Vorhees CV

    更新日期:1989-05-01 00:00:00

  • Sociodemographic factors modifying the effect of environmental lead on neuropsychological development in early childhood.

    abstract::A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

    更新日期:1992-09-01 00:00:00

  • Prenatal testosterone increases sensitivity to prenatal stressors in males with disruptive behavior disorders.

    abstract::Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten the risk for DBD symptoms in males by increasing ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Martel MM,Roberts BA

    更新日期:2014-07-01 00:00:00

  • Development of neurons and synapses in ochratoxin A-induced microcephalic mice: a quantitative assessment of somatosensory cortex.

    abstract::Ochratoxin A (a mycotoxin) is known to cause cell death in the developing brain of embryos 1-2 days after treatment. Microcephaly was observed with high frequency in mice by prenatal treatment with ochratoxin A. Using a stereological method, the numerical densities of neurons and synapses were investigated in the soma...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fukui Y,Hayasaka S,Itoh M,Takeuchi Y

    更新日期:1992-05-01 00:00:00

  • Infants of drug addicts: at risk for child abuse, neglect, and placement in foster care.

    abstract::In a methadone maintenance program for pregnant, drug dependent women, an investigation was undertaken (1) to study the occurrence of violence experienced by the women as children and as adults and (2) to lean whether those who report past violence/abuse are more likely to neglect and/or abandon their children to the ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Regan DO,Ehrlich SM,Finnegan LP

    更新日期:1987-07-01 00:00:00

  • Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening.

    abstract::Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fan CY,Cowden J,Simmons SO,Padilla S,Ramabhadran R

    更新日期:2010-01-01 00:00:00

  • Structural Magnetic Resonance Imaging in an adult cohort following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water.

    abstract::This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Janulewicz PA,Killiany RJ,White RF,Martin BM,Winter MR,Weinberg JM,Aschengrau A

    更新日期:2013-07-01 00:00:00

  • Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin.

    abstract::Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Habr SF,Macrini DJ,Florio JC,Bernardi MM

    更新日期:2014-11-01 00:00:00

  • The effects of perinatal AZT exposure on the acoustic startle response in adult rats.

    abstract::AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Melnick SM,Weedon J,Dow-Edwards DL

    更新日期:2002-11-01 00:00:00

  • Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats.

    abstract::Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

    更新日期:2005-01-01 00:00:00

  • Monitoring protein phosphatase 1 isoform levels as a marker for cellular stress.

    abstract::Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Amador FC,Henriques AG,da Cruz E Silva OA,da Cruz E Silva EF

    更新日期:2004-05-01 00:00:00

  • Repeated methylphenidate administration during lactation reduces maternal behavior, induces maternal tolerance, and increases anxiety-like behavior in pups in adulthood.

    abstract::Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Ponchio RA,Teodorov E,Kirsten TB,Coelho CP,Oshiro A,Florio JC,Bernardi MM

    更新日期:2015-07-01 00:00:00

  • Effect of lead exposure on patterns of food intake in weanling rats.

    abstract::The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Minnema DJ,Hammond PB

    更新日期:1994-11-01 00:00:00

  • Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.

    abstract::Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Oliveri AN,Ortiz E,Levin ED

    更新日期:2018-01-01 00:00:00

  • Preliminary indications that functional effects of fetal caffeine exposure can be expressed in a second generation.

    abstract::Caffeine, added to the drinking water of males used for impregnation and gestant BALB/c mice such that their daily caffeine intake was 60 mg/kg, modified the passive avoidance behavior of the offspring when tested as adults. Caffeine-treated and control mice of the F1 generation were then cross-mated. The F2 generatio...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Sinton CM

    更新日期:1989-07-01 00:00:00

  • Factors influencing diisopropyl fluorophosphate-induced hypothermia and hyperthermia in the rat.

    abstract::Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Gordon CJ

    更新日期:1995-11-01 00:00:00

  • Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats.

    abstract::Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Amin S,Moore RW,Peterson RE,Schantz SL

    更新日期:2000-09-01 00:00:00

  • Behavioral evaluations in developmental toxicity testing: MARTA survey results.

    abstract::During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lochry EA,Johnson C,Wier PJ

    更新日期:1994-01-01 00:00:00

  • Retinal lesions in rat fetuses prenatally exposed to cocaine.

    abstract::The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Méndez-Armenta M,Barroso-Moguel R,Villeda-Hernández J,Romero-Díaz V,Ríos C

    更新日期:1997-05-01 00:00:00

  • Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.

    abstract::Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Silva L,Zhao N,Popp S,Dow-Edwards D

    更新日期:2012-01-01 00:00:00

  • Failure of acute cocaine administration to differentially affect acoustic startle and activity in rats prenatally exposed to cocaine.

    abstract::Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Foss JA,Riley EP

    更新日期:1991-09-01 00:00:00

  • Prospects on behavioral studies of marine and freshwater toxins.

    abstract::While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: MacPhail RC,Jarema KA

    更新日期:2005-09-01 00:00:00

  • Gender and alcohol moderate caregiver reported child behavior after prenatal cocaine.

    abstract:OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Sood BG,Nordstrom Bailey B,Covington C,Sokol RJ,Ager J,Janisse J,Hannigan JH,Delaney-Black V

    更新日期:2005-03-01 00:00:00

  • Prenatal cocaine use and maternal depression: effects on infant neurobehavior.

    abstract:OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,多中心研究


    authors: Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

    更新日期:2007-05-01 00:00:00

  • Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese.

    abstract::The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Golub MS,Hogrefe CE,Germann SL,Tran TT,Beard JL,Crinella FM,Lonnerdal B

    更新日期:2005-07-01 00:00:00

  • Toxic exposure to ethylene dibromide and mercuric chloride: effects on laboratory-reared octopuses.

    abstract::The effects of acute and chronic exposure to either ethylene dibromide (EDB) or mercuric chloride (MC) were studied in laboratory-reared Octopus joubini, O. maya and O. bimaculoides. The advantages of using octopuses were that the responses were immediate, highly visible and sensitive. All species demonstrated signs o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Adams PM,Hanlon RT,Forsythe JW

    更新日期:1988-11-01 00:00:00