Abstract:
:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2 h (2HP) on gestational day 18. An additional group (lipid) was assigned to receive continuous infusion of intralipid fat emulsion (vehicle of propofol) for 2 h. Pups were then tested on the appearance and progression of sensory and physical motor abilities between postnatal day 1 (P1) and P28. The brain and body weights of pups from 2HP group on P10 were significantly lower than those from the saline control group, although they were the same in all four groups at birth (P0). Pups from 1HP and 2HP groups, but not lipid group, showed slower maturation of eyes (delayed opening) and several neurological reflexes (hindlimb reflex, righting reflex); they also showed delayed improvement in execution on gait reflex and inclined board tests. The forelimb reflex and negative geotaxis were also delayed in 2HP group. All parameters examined except body weight of 2HP pups recovered to normal levels by P28. We conclude that administration of propofol to pregnant rats leads to retardation in physical and neurological reflex development in their offspring.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker Adoi
10.1016/j.ntt.2014.03.006subject
Has Abstractpub_date
2014-05-01 00:00:00pages
51-8eissn
0892-0362issn
1872-9738pii
S0892-0362(14)00039-7journal_volume
43pub_type
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journal_title:Neurotoxicology and teratology
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