Behavioral deficits due to prenatal exposure to cadmium chloride in CFY rat pups.

abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...

journal_title：Neurotoxicology and teratology

authors： Mitchell JA,Long SF,Wilson MC,Kallman MJ

更新日期：1989-01-01 00:00:00

abstract：:We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the striatum by MPTP. Following MPTP treatment, increased GFAP immunoreactivity reached a peak at 2 days and persisted for at least 6 weeks. Immunoreactivity to vimentin was also markedly increased in astrocytes 48 h...

journal_title：Neurotoxicology and teratology

authors： Francis JW,Von Visger J,Markelonis GJ,Oh TH

更新日期：1995-01-01 00:00:00

abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

journal_title：Neurotoxicology and teratology

authors： Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

更新日期：2010-07-01 00:00:00

abstract：:The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. We established mechanistically-based complementary models for the study of cholinergic systems in...

journal_title：Neurotoxicology and teratology

authors： Yanai J,Brick-Turin Y,Dotan S,Langford R,Pinkas A,Slotkin TA

更新日期：2010-01-01 00:00:00

abstract：:The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...

journal_title：Neurotoxicology and teratology

authors： Lipton JW,Yuengsrigul A,Ling ZD,Weese-Mayer DE,Carvey PM

更新日期：1996-05-01 00:00:00

abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

journal_title：Neurotoxicology and teratology

authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

更新日期：2014-05-01 00:00:00

abstract：:We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...

journal_title：Neurotoxicology and teratology

authors： Neuspiel DR,Hamel SC,Hochberg E,Greene J,Campbell D

更新日期：1991-03-01 00:00:00

abstract：:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

journal_title：Neurotoxicology and teratology

authors： MacPhail RC,Jarema KA

更新日期：2005-09-01 00:00:00

abstract：:Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. The treatment was continued in nursing mothers until postnatal day 7. All studies were performed in their offsprings on pos...

journal_title：Neurotoxicology and teratology

authors： Hseu SS,Yien HW,Du F,Sun LS

更新日期：1998-11-01 00:00:00

abstract：:Subcutaneous injection of a sublethal dose of chlorpyrifos (CHLP), an organophosphate (OP) pesticide, causes long-term inhibition in cholinesterase activity (ChE) of brain, blood, and other tissues. Such prolonged inhibition in ChE should lead to marked behavioral and autonomic thermoregulatory patterns, especially in...

journal_title：Neurotoxicology and teratology

authors： Gordon CJ

更新日期：1994-01-01 00:00:00

abstract：:Toluene can be considered an ototoxic chemical compound in the rat. Outer hair cells are particularly sensitive to this aromatic organic solvent or to one of its metabolites. The objective of the present study was to evaluate the possible role played by cysteine S-conjugates in the ototoxic process in Long-Evans rats....

journal_title：Neurotoxicology and teratology

authors： Waniusiow D,Campo P,Cossec B,Cosnier F,Grossman S,Ferrari L

更新日期：2008-05-01 00:00:00

abstract：:The effects of acute and chronic exposure to either ethylene dibromide (EDB) or mercuric chloride (MC) were studied in laboratory-reared Octopus joubini, O. maya and O. bimaculoides. The advantages of using octopuses were that the responses were immediate, highly visible and sensitive. All species demonstrated signs o...

journal_title：Neurotoxicology and teratology

authors： Adams PM,Hanlon RT,Forsythe JW

更新日期：1988-11-01 00:00:00

abstract：:Cigarette smoking in pregnant women has been shown to lead to intrauterine growth retardation and fetal death, and possibly also to neural dysmorphology and long-term learning deficits in the offspring. Because the teratogenic agent in cigarette smoke remains controversial, the present study on rat embryos in culture ...

journal_title：Neurotoxicology and teratology

authors： Joschko MA,Dreosti IE,Tulsi RS

更新日期：1991-05-01 00:00:00

abstract：:Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific per...

journal_title：Neurotoxicology and teratology

authors： Braquenier JB,Quertemont E,Tirelli E,Plumier JC

更新日期：2010-03-01 00:00:00

abstract：:Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...

journal_title：Neurotoxicology and teratology

authors： Bond NW

更新日期：1988-01-01 00:00:00

abstract：:Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...

journal_title：Neurotoxicology and teratology

authors： Goulet S,Doré FY,Mirault ME

更新日期：2003-05-01 00:00:00

abstract：:The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

journal_title：Neurotoxicology and teratology

authors： de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

更新日期：2012-11-01 00:00:00

abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...

journal_title：Neurotoxicology and teratology

authors： Minck DR,Erway LC,Vorhees CV

更新日期：1989-05-01 00:00:00

abstract：:Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B,Gray R

更新日期：2003-07-01 00:00:00

abstract：:Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. Male Long-Evans rats were implanted with electrodes in the amygdala or dorsal dentate gyrus, and injected IP daily with 40 mg/kg CDF,...

journal_title：Neurotoxicology and teratology

authors： Gilbert ME

更新日期：1988-05-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

journal_title：Neurotoxicology and teratology

authors： Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

更新日期：2018-01-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...

journal_title：Neurotoxicology and teratology

authors： Yin HS,Tan HW

更新日期：2007-03-01 00:00:00

abstract：:The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...

journal_title：Neurotoxicology and teratology

authors： Méndez-Armenta M,Barroso-Moguel R,Villeda-Hernández J,Romero-Díaz V,Ríos C

更新日期：1997-05-01 00:00:00

abstract：:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...

journal_title：Neurotoxicology and teratology

authors： Geller AM,Bushnell PJ,Rice DC

更新日期：2000-07-01 00:00:00

abstract：:Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some ...

journal_title：Neurotoxicology and teratology

authors： Li C,Schaefer M,Gray C,Yang Y,Furmanski O,Liu S,Worley P,Mintz CD,Tao F,Johns RA

更新日期：2017-01-01 00:00:00

abstract：:Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

journal_title：Neurotoxicology and teratology

authors： Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

更新日期：2015-07-01 00:00:00

abstract：:The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...

journal_title：Neurotoxicology and teratology

authors： Feng L,Xiao H,He X,Li Z,Li F,Liu N,Chai Z,Zhao Y,Zhang Z

更新日期：2006-01-01 00:00:00

abstract：:Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...

journal_title：Neurotoxicology and teratology

authors： de Souza Spinosa H,Nicolau A,Maruo VM,Bernardi MM

更新日期：1999-07-01 00:00:00