Prospects on behavioral studies of marine and freshwater toxins.

Abstract:

:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, are known to occasionally "bloom" and produce toxins that can cause either blatant toxicity (i.e., lethality) or damage to a number of organ systems. The nervous system is a known target for many of the toxins. Considerable research has in the past been carried out to determine toxin effects on the survivability of laboratory rodents (typically mice) following acute exposures. Newer research has shown, however, prominent toxin-induced alterations in motor, sensory, autonomic and cognitive functions at sublethal exposure concentrations. Future toxin research can capitalize upon a wealth of behavioral paradigms already available in toxicology, pharmacology and neuroscience.

journal_name

Neurotoxicol Teratol

authors

MacPhail RC,Jarema KA

doi

10.1016/j.ntt.2005.06.007

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

695-9

issue

5

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(05)00085-1

journal_volume

27

pub_type

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