Abstract：
:Although cocaine administration reduces blood flow to the fetus in the pregnant ewe, the effects of cocaine on uterine and placental blood flow in the pregnant rat have not been adequately documented. The current study tested the hypothesis that cocaine decreased uterine and placental blood flow in awake and freely moving pregnant rats 17 min following gastric intubation. Blood flow was determined using [14C]iodoantipyrine in pregnant Sprague-Dawley rats 1 day prior to parturition. On the day of the experiment, rats were intubated with either 60 mg/kg cocaine or the vehicle and 17 min later infused i.v. with 75 microCi [14C]iodoantipyrine. Ten arterial blood samples were taken over 1 min through a femoral arterial catheter placed on the previous day. At 1 min the animal was decapitated and the entire uterus rapidly removed and frozen. After processing for autoradiography, the amounts of radioactivity in the tissues were determined by computerized image analysis. The results show that cocaine reduced blood flow in the uterus by 27% and decreased blood flow in the placenta by 30%. While cocaine reduced the total amount of iodoantipyrine reaching the fetus, the distribution of tracer within the fetus did not appear to be altered by cocaine. Maternal blood pressure and heart rate decreased by 5% and 13% respectively (paired t-test), while maternal and fetal blood gases were not altered. These data indicate that acute cocaine administration reduces uteroplacental blood flow in the rat. The duration of this effect and whether these decreases are sufficient to produce neurobehavioral changes in the offspring remain to be determined.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Patel TG,Laungani RG,Grose EA,Dow-Edwards DLdoi
10.1016/s0892-0362(99)00022-7subject
Has Abstractpub_date
1999-09-01 00:00:00pages
559-65issue
5eissn
0892-0362issn
1872-9738pii
S0892-0362(99)00022-7journal_volume
21pub_type
杂志文章abstract：:We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the striatum by MPTP. Following MPTP treatment, increased GFAP immunoreactivity reached a peak at 2 days and persisted for at least 6 weeks. Immunoreactivity to vimentin was also markedly increased in astrocytes 48 h...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)00048-i
更新日期：1995-01-01 00:00:00
abstract：:Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world....
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2006.09.027
更新日期：2007-03-01 00:00:00
abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.10.002
更新日期：2005-01-01 00:00:00
abstract：:Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(98)00039-7
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ntt.2006.12.001
更新日期：2007-05-01 00:00:00
abstract：:Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(02)00197-6
更新日期：2002-05-01 00:00:00
abstract：:Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2015.05.008
更新日期：2015-07-01 00:00:00
abstract：:To determine whether there is an association between moderate alcohol consumption in the first trimester of pregnancy and increased risk of fetal malformations, we conducted a literature search using Medline (1966-present), PsycLit (1974-1995), and EMBASE (1988-1995). The following inclusion criteria were used to sele...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,meta分析
doi：10.1016/s0892-0362(97)00073-1
更新日期：1998-01-01 00:00:00
abstract：:Volatile organic solvent (inhalant) abuse continues to be a major health concern throughout the world. Of particular concern is the abuse of inhalants by adolescents because of its toxicity and link to illicit drug use. Toluene, which is found in many products such as glues and household cleaners, is among the most co...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2007.08.001
更新日期：2007-11-01 00:00:00
abstract：:The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90093-1
更新日期：1988-11-01 00:00:00
abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90084-6
更新日期：1989-01-01 00:00:00
abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2016.06.005
更新日期：2016-07-01 00:00:00
abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)00187-0
更新日期：1997-01-01 00:00:00
abstract：:The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.07.005
更新日期：2011-09-01 00:00:00
abstract：:This study examined the effects of chronic postweaning lead (Pb) exposure in Long-Evans rats on a series of spatial alternation tasks. All tasks were administered in automated testing chambers, with a nosepoke as the critical response. While neither Pb-exposed group (median blood lead levels: 19 and 39 micrograms/dl, ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(95)02026-8
更新日期：1996-01-01 00:00:00
abstract：:Risk assessment of developmental toxicants is almost exclusively based on single chemicals studied in animals under controlled experimental conditions, as to reduce stress. Although humans may be exposed simultaneously to numerous hazards, little is known about the interaction of prenatal chemical exposures with other...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2007.02.003
更新日期：2007-07-01 00:00:00
abstract：:Employees of a factory producing antiknock additives for gasoline were examined psychologically after an exposure of an average of 14 years. A neurobehavioral symptom questionnaire, tests of single and choice reaction time, a cancellation task and a digit symbol test were the neurobehavioral variables. Total lead in u...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(90)90080-v
更新日期：1990-11-01 00:00:00
abstract：:This nonconcurrent, cohort study of consecutive admissions to one of three hospital units: labor and delivery (n = 474), well-born nursery (n = 100), and the neonatal intensive care unit (n = 100), was designed to determine the prevalence of cocaine exposure in a rural obstetrical sample and to determine the relations...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90126-0
更新日期：1994-09-01 00:00:00
abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/S0892-0362(03)00093-X
更新日期：2004-01-01 00:00:00
abstract：:High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/s0892-0362(98)00027-0
更新日期：1999-01-01 00:00:00
abstract：:In the literature on the effects of early exposure to neurotoxic agents on infant and child development, considerable attention has been devoted to two important issues--ascertainment of exposure and spurious correlation. In this paper, we review these research challenges and focus on three additional issues that, in ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2005.01.009
更新日期：2005-05-01 00:00:00
abstract：:A pharmacological challenge of nonhuman primate open field behavior, similar to that which previously assessed the cholinergic system (10), was used here to measure potential lead-induced alterations in the dopaminergic system. Monkeys that had been treated with lead during the first year postpartum were assessed at 7...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(95)02050-0
更新日期：1996-03-01 00:00:00
abstract：:In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO₃) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V₁ group) or with 7.2 mg/kg bw/day of NaVO₃ (V₂ group) for 5 consecutive days. Results show tha...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.10.010
更新日期：2011-03-01 00:00:00
abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90027-2
更新日期：1994-07-01 00:00:00
abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90073-1
更新日期：1989-05-01 00:00:00
abstract：:Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(01)00193-3
更新日期：2002-01-01 00:00:00
abstract：:A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90089-f
更新日期：1991-07-01 00:00:00
abstract：:A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/s0892-0362(97)00061-5
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2013.12.006
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2019.106812
更新日期：2019-01-01 00:00:00
