Abstract:
:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring active avoidance learning in normal and SOX-deficient rats. For this purpose, male albino rats used in this study were divided into eight groups such as control group (C), sulfite group (25 mg/kg) (S), vitamin E group (50 mg/kg) (E), sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (SE), SOX-deficient group (D), deficient+vitamin E group (50 mg/kg) (DE), deficient+sulfite group (25 mg/kg) (DS) and deficient+sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (DSE). Sulfite-induced impairment of active avoidance learning in SOX-deficient rats but not in normal rats. Sulfite had no effect on hippocampus TBARS levels in SOX normal groups. In SOX-deficient rats, TBARS levels were found to be significantly increased with sulfite exposure. Vitamin E reversed the observed detrimental effects of sulfite in the SOX-deficient rats on their hippocampal TBARS but not on their active avoidance learning. In conclusion, sulfite has neurotoxic effects in sulfite oxidase deficient rats, but this effect may not depend on oxidative stress.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar Adoi
10.1016/j.ntt.2004.10.002subject
Has Abstractpub_date
2005-01-01 00:00:00pages
47-54issue
1eissn
0892-0362issn
1872-9738pii
S0892-0362(04)00143-6journal_volume
27pub_type
杂志文章abstract::This is the first in a series of studies investigating the developmental stage-specific neurobehavioral effects of all-trans retinoic acid (RA) exposure. Because high doses of this compound are known to be lethal to the developing organism, we first conducted a dose-response study to identify RA doses that produce low...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2007.08.001
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2011.08.008
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2009.07.004
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2011.10.006
更新日期:2012-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/s0892-0362(96)00125-0
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(93)90007-b
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:2002-09-01 00:00:00
abstract::Although cocaine administration reduces blood flow to the fetus in the pregnant ewe, the effects of cocaine on uterine and placental blood flow in the pregnant rat have not been adequately documented. The current study tested the hypothesis that cocaine decreased uterine and placental blood flow in awake and freely mo...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(99)00022-7
更新日期:1999-09-01 00:00:00