当前位置： SCI文献检索 > NEUROTOXICOLOGY AND TERATOLOGY期刊下所有文献 > Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.

Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.

Abstract：

:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental to normal cognition and memory. In this study, we examined the effects of daily intravenous injections of 0.15 mg/kg Δ(9)-tetrahydrocannabinol (THC), given to pregnant dams throughout gestation, on cognitive function in the offspring. Offspring were exposed to three tests: a passive avoidance test at postnatal day (PND) 22, an active place avoidance test at PND 45, and an attention task at PND 60, which assessed learning and long-term memory, spatial working memory and prediction, and attention, respectively. Other offspring were also given a 1mg/kg amphetamine challenge at PND 60. Passive avoidance testing showed that prenatal THC had no effect on acquisition but interfered with consolidation during retention testing. The active place avoidance task showed no treatment-related effects on acquisition but a significant treatment effect was observed in reversal performance in males. The attention task showed that a smaller percentage of THC-exposed rats completed the test, although the failure rate of both groups was quite high. Finally, THC exposed animals, both male and female, showed a dampened locomotor response to amphetamine, but females were more active than males overall. These results suggest that prenatal THC exposure has effects on certain aspects of cognitive function in rats from weaning to adulthood. These effects suggest that prenatal marijuana exposure could also alter cognitive function in humans and therefore have an impact on school performance and dampen responses to psychostimulants as well.

journal_name

Neurotoxicol Teratol

journal_title

Neurotoxicology and teratology

authors

Silva L,Zhao N,Popp S,Dow-Edwards D

doi

10.1016/j.ntt.2011.10.006

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

63-71

issue

1

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(11)00205-4

journal_volume

34

pub_type

杂志文章

相关文献

NEUROTOXICOLOGY AND TERATOLOGY文献大全
  • Prenatal cocaine exposure and postnatal hypoxia independently decrease carotid body dopamine in neonatal rats.

    abstract：:The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(96)90027-6

    authors： Lipton JW,Yuengsrigul A,Ling ZD,Weese-Mayer DE,Carvey PM

    更新日期：1996-05-01 00:00:00

  • Prenatal ethanol exposure decreases hippocampal 3H-vinylidene kainic acid binding in 45-day-old rats.

    abstract：:The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(88)90093-1

    authors： Farr KL,Montano CY,Paxton LL,Savage DD

    更新日期：1988-11-01 00:00:00

  • An in-depth analysis of lead effects in a delayed spatial alternation task: assessment of mnemonic effects, side bias, and proactive interference.

    abstract：:This study examined the effects of chronic postweaning lead (Pb) exposure in Long-Evans rats on a series of spatial alternation tasks. All tasks were administered in automated testing chambers, with a nosepoke as the critical response. While neither Pb-exposed group (median blood lead levels: 19 and 39 micrograms/dl, ...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(95)02026-8

    authors： Alber SA,Strupp BJ

    更新日期：1996-01-01 00:00:00

  • Breast-feeding and gender as moderators of teratogenic effects on cognitive development.

    abstract：:Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(02)00197-6

    authors： Jacobson JL,Jacobson SW

    更新日期：2002-05-01 00:00:00

  • Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides.

    abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2010.03.004

    authors： Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

    更新日期：2010-07-01 00:00:00

  • Influence of dosing volume on the neurotoxicity of bifenthrin.

    abstract：:Pyrethroids are pesticides with high insecticidal activity and relatively low potency in mammals. The influence of dosing volume on the neurobehavioral syndrome following oral acute exposure to the Type-I pyrethroid insecticide bifenthrin in corn oil was evaluated in adult male Long Evans rats. We tested bifenthrin ef...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2007.01.007

    authors： Wolansky MJ,McDaniel KL,Moser VC,Crofton KM

    更新日期：2007-05-01 00:00:00

  • Neurophysiological markers as early signs of organophosphate neurotoxicity.

    abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(88)90004-9

    authors： Nagymajtényi L,Dési I,Lorencz R

    更新日期：1988-09-01 00:00:00

  • Behavioral and monoaminergic changes after lindane exposure in developing rats.

    abstract：:The effects of lindane on behavior and central monoaminergic systems were studied in rat pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO doses, either a single 20 mg/kg or 7-day repeated 10 mg/kg doses. Both treatment schedules improved the passive avoidance acquisition but only t...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(97)00079-2

    authors： Rivera S,Rosa R,Martínez E,Suñol C,Serrano MT,Vendrell M,Rodríguez-Farré E,Sanfeliu C

    更新日期：1998-03-01 00:00:00

  • Long-term effects of lanthanum intake on the neurobehavioral development of the rat.

    abstract：:The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2005.10.007

    authors： Feng L,Xiao H,He X,Li Z,Li F,Liu N,Chai Z,Zhao Y,Zhang Z

    更新日期：2006-01-01 00:00:00

  • Effects of amphetamine on serotoninergic and GABAergic expression of developing brain.

    abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2006.10.001

    authors： Yin HS,Tan HW

    更新日期：2007-03-01 00:00:00

  • WITHDRAWN: Use of Interval Schedules to Examine Motivation and Sustained Attention.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2007.08.006

    authors： Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

    更新日期：2009-02-05 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract：:4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2011.09.009

    authors： Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期：2011-11-01 00:00:00

  • Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats.

    abstract：:The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(97)00002-0

    authors： Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

    更新日期：1997-07-01 00:00:00

  • A fostering/crossfostering analysis of the effects of prenatal ethanol exposure in a liquid diet on offspring development and behavior in rats.

    abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(89)90049-4

    authors： Vorhees CV

    更新日期：1989-03-01 00:00:00

  • Long-term effects of toluene inhalation on rat behavior.

    abstract：:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(91)90052-x

    authors： Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

    更新日期：1991-09-01 00:00:00

  • Ethanol-induced cell death in cultured rat astroglia.

    abstract：:Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(96)00226-7

    authors： Holownia A,Ledig M,Ménez JF

    更新日期：1997-03-01 00:00:00

  • Ethanol inhibition of brain ornithine decarboxylase activity in the postnatal rat.

    abstract：:The purpose of this study was to determine the relationship between ornithine decarboxylase activity (ODC; a marker for perturbed cell development), the blood alcohol level, and alcohol-induced microencephaly in the developing rat brain after binge treatment with ethanol vapour. By manipulating ethanol flow we were ab...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(97)00135-9

    authors： Davidson M,Bedi K,Wilce P

    更新日期：1998-09-01 00:00:00

  • Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior.

    abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2016.10.009

    authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

    更新日期：2017-05-01 00:00:00

  • Effects of high doses of toluene on color vision.

    abstract：:High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...

    journal_title：Neurotoxicology and teratology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0892-0362(98)00027-0

    authors： Muttray A,Wolters V,Jung D,Konietzko J

    更新日期：1999-01-01 00:00:00

  • Central auditory processing in school-age children prenatally exposed to cigarette smoke.

    abstract：:One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...

    journal_title：Neurotoxicology and teratology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0892-0362(94)90048-5

    authors： McCartney JS,Fried PA,Watkinson B

    更新日期：1994-05-01 00:00:00

  • Prenatal alcohol exposure and offspring hyperactivity: effects of physostigmine and neostigmine.

    abstract：:Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(88)90067-0

    authors： Bond NW

    更新日期：1988-01-01 00:00:00

  • Exposure to mephedrone during gestation increases the risk of stillbirth and induces hippocampal neurotoxicity in mice offspring.

    abstract：:In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2018.03.001

    authors： Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

    更新日期：2018-01-01 00:00:00

  • Exacerbation of iminodipropionitrile-induced behavioral toxicity, oxidative stress, and vestibular hair cell degeneration by gentamicin in rats.

    abstract：:This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(99)00075-6

    authors： Al Deeb S,Al Moutaery K,Khan HA,Tariq M

    更新日期：2000-03-01 00:00:00

  • Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles.

    abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2018.10.003

    authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

    更新日期：2018-01-01 00:00:00

  • Effect of late fetal irradiation on adult behavior of mouse: Dose-response relationship.

    abstract：:Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/s0892-0362(98)00039-7

    authors： Devi PU,Hossain M,Bisht KS

    更新日期：1999-03-01 00:00:00

  • Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents.

    abstract：:The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2008.01.006

    authors： Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

    更新日期：2008-05-01 00:00:00

  • Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells.

    abstract：:Amitraz is a formamidine pesticide that has been reported to be a neurotoxic compound that induces convulsions among other effects. Excitatory and inhibitory neurotransmission is mediated mainly by glutamate and GABA, respectively, so their alteration could be responsible for induction of seizures. In this regard, ami...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2015.06.007

    authors： Del Pino J,Frejo MT,Baselga MJ,Moyano P,Díaz MJ

    更新日期：2015-07-01 00:00:00

  • Prenatal ethanol exposure in rats: long-lasting effects on learning.

    abstract：:Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed under a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior ...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(95)00014-i

    authors： Clausing P,Ferguson SA,Holson RR,Allen RR,Paule MG

    更新日期：1995-09-01 00:00:00

  • Maternal cocaine use and infant behavior.

    abstract：:We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/0892-0362(91)90015-o

    authors： Neuspiel DR,Hamel SC,Hochberg E,Greene J,Campbell D

    更新日期：1991-03-01 00:00:00

  • Effects of prenatal propofol exposure on postnatal development in rats.

    abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

    journal_title：Neurotoxicology and teratology

    pub_type： 杂志文章

    doi：10.1016/j.ntt.2014.03.006

    authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

    更新日期：2014-05-01 00:00:00