Behavioral and monoaminergic changes after lindane exposure in developing rats.

abstract：:The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...

journal_title：Neurotoxicology and teratology

authors： Lipton JW,Yuengsrigul A,Ling ZD,Weese-Mayer DE,Carvey PM

更新日期：1996-05-01 00:00:00

abstract：:This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...

journal_title：Neurotoxicology and teratology

authors： Allen RR,Slikker W Jr,Paule MG

更新日期：1990-09-01 00:00:00

abstract：:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

journal_title：Neurotoxicology and teratology

authors： Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

更新日期：1991-09-01 00:00:00

abstract：:A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...

journal_title：Neurotoxicology and teratology

authors： Lam HR,Larsen JJ,Ladefoged O,Møller A,Strange P,Arlien-Søborg P

更新日期：1991-07-01 00:00:00

abstract：:Following the passage of the Food Quality Protection Act, which mandated an increased focus on evaluating the potential toxicity of pesticides to children, the number of guideline developmental neurotoxicity (DNT) studies (OPPTS 870.6300) submitted to the U.S. Environmental Protection Agency (EPA) Office of Pesticide ...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Rowland J,May B,Makris SL,Schumacher K,Scarano LJ

更新日期：2010-09-01 00:00:00

abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Newport GD,Callicott R,Liu S,Thompson J,Berridge MS,Apana SM,Slikker W Jr,Wang C,Paule MG

更新日期：2016-07-01 00:00:00

abstract：:Chemical warfare nerve agents (CWNAs) are known to cause behavioral abnormalities in cases of human exposures and in animal models. The behavioral consequences of single exposures to CWNAs that cause observable toxic signs are particularly well characterized in animals; however, less is known regarding repeated smalle...

journal_title：Neurotoxicology and teratology

authors： Smith CD,Lee RB,Moran AV,Sipos ML

更新日期：2016-03-01 00:00:00

abstract：:Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world....

journal_title：Neurotoxicology and teratology

authors： Bowen SE,Mohammadi MH,Batis JC,Hannigan JH

更新日期：2007-03-01 00:00:00

abstract：:The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...

journal_title：Neurotoxicology and teratology

authors： Li AA,Sheets LP,Raffaele K,Moser V,Hofstra A,Hoberman A,Makris SL,Garman R,Bolon B,Kaufmann W,Auer R,Lau E,Vidmar T,Bowers WJ

更新日期：2017-09-01 00:00:00

abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

journal_title：Neurotoxicology and teratology

authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

更新日期：2017-05-01 00:00:00

abstract：:Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ

更新日期：2013-03-01 00:00:00

abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

journal_title：Neurotoxicology and teratology

authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

更新日期：2018-01-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Neurotoxicology and teratology

authors： Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

更新日期：2009-02-05 00:00:00

abstract：:The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...

journal_title：Neurotoxicology and teratology

authors： Golub MS,Hogrefe CE,Germann SL,Tran TT,Beard JL,Crinella FM,Lonnerdal B

更新日期：2005-07-01 00:00:00

abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

journal_title：Neurotoxicology and teratology

authors： Minnema DJ,Hammond PB

更新日期：1994-11-01 00:00:00

abstract：:Animals exposed prenatally to alcohol (4 g/kg/day) via maternal peroral intubation or control offspring were reared after weaning either alone in standard steel/wire cages or in groups of eight, for 6 weeks. Rats exposed prenatally to alcohol and reared in isolation had a dysmetric stride length indicative of an ataxi...

journal_title：Neurotoxicology and teratology

authors： Hannigan JH,Berman RF,Zajac CS

更新日期：1993-07-01 00:00:00

abstract：:Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...

journal_title：Neurotoxicology and teratology

authors： Hitchcock EM,Dick RB,Krieg EF

更新日期：2004-03-01 00:00:00

abstract：:The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Th...

journal_title：Neurotoxicology and teratology

authors： Warren DA,Reigle TG,Muralidhara S,Dallas CE

更新日期：1998-03-01 00:00:00

abstract：:Ionizing radiation is a precise tool for altering formation of the developing cerebral cortex of the fetal rat. Whole body exposure of the pregnant rat on gestational day 13, 15 or 17 to 1.0 Gy of gamma radiation resulted in maximum thinning of the cortex on days 15 and 17. In the preweaning period, functional tests (...

journal_title：Neurotoxicology and teratology

authors： Norton S,Kimler BF

更新日期：1988-07-01 00:00:00

abstract：:Zidovudine (AZT) is the main therapeutic agent against HIV vertical transmission and is routinely administered to seropositive pregnant women and their newborns. Toxicity after chronic administration as well as citogenetic effects following developmental AZT exposure has been reported. Furthermore, recent animal data ...

journal_title：Neurotoxicology and teratology

authors： Venerosi A,Valanzano A,Puopolo M,Calamandrei G

更新日期：2005-01-01 00:00:00

abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B

更新日期：2000-01-01 00:00:00

abstract：:The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

journal_title：Neurotoxicology and teratology

authors： de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

更新日期：2012-11-01 00:00:00

abstract：:Perfluorinated alkyls are widely-used agents that accumulate in ecosystems and organisms because of their slow rate of degradation. There is increasing concern that these agents may be developmental neurotoxicants and the present study was designed to develop an avian model for the neurobehavioral teratogenicity of pe...

journal_title：Neurotoxicology and teratology

authors： Pinkas A,Slotkin TA,Brick-Turin Y,Van der Zee EA,Yanai J

更新日期：2010-03-01 00:00:00

abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...

journal_title：Neurotoxicology and teratology

authors： Fulginiti S,Minetti SA,Virgolini MB

更新日期：1994-07-01 00:00:00

abstract：:Neurobehavioral studies often employ test batteries and confront issues of multiple testing and comparability between batteries. We have organized our battery of 12 tests into areas of neurobehavioral function to reduce the number of reported results, provide greater statistical power, and improve interpretability of ...

journal_title：Neurotoxicology and teratology

authors： Heyer NJ,Bittner AC Jr,Echeverria D

更新日期：1996-07-01 00:00:00

abstract：:This is the first in a series of studies investigating the developmental stage-specific neurobehavioral effects of all-trans retinoic acid (RA) exposure. Because high doses of this compound are known to be lethal to the developing organism, we first conducted a dose-response study to identify RA doses that produce low...

journal_title：Neurotoxicology and teratology

authors： Holson RR,Gazzara RA,Ferguson SA,Ali SF,Laborde JB,Adams J

更新日期：1997-09-01 00:00:00

abstract：:Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...

journal_title：Neurotoxicology and teratology

authors： Peele DB,Crofton KM

更新日期：1987-09-01 00:00:00

abstract：:The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behav...

journal_title：Neurotoxicology and teratology

authors： Temple JG,Miller DB,Barthalmus GT

更新日期：2002-03-01 00:00:00