Abstract：
:Perfluorinated alkyls are widely-used agents that accumulate in ecosystems and organisms because of their slow rate of degradation. There is increasing concern that these agents may be developmental neurotoxicants and the present study was designed to develop an avian model for the neurobehavioral teratogenicity of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Fertilized chicken eggs were injected with 5 or 10mg/kg of either compound on incubation day 0. On the day of hatching, imprinting behavior was impaired by both compounds. We then explored underlying mechanisms involving the targeting of protein kinase C (PKC) isoforms (alpha, beta, gamma) in the intermedial part of the hyperstriatum ventrale, the region most closely associated with imprinting. With PFOA exposure, cytosolic PKC concentrations were significantly elevated for all three isoforms; despite the overall increase in PKC expression, membrane-associated PKC was unaffected, indicating a defect in PKC translocation. In contrast, PFOS exposure evoked a significant decrease in cytosolic PKC, primarily for the beta and gamma isoforms, but again without a corresponding change in membrane-associated enzyme; this likely partial, compensatory increases in translocation to offset the net PKC deficiency. Our studies indicate that perfluorinated alkyls are indeed developmental neurotoxicants that affect posthatch cognitive performance but that the underlying synaptic mechanisms may differ substantially among the various members of this class of compounds, setting the stage for disparate outcomes later in life.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Pinkas A,Slotkin TA,Brick-Turin Y,Van der Zee EA,Yanai Jdoi
10.1016/j.ntt.2009.11.004subject
Has Abstractpub_date
2010-03-01 00:00:00pages
182-6issue
2eissn
0892-0362issn
1872-9738pii
S0892-0362(09)00198-6journal_volume
32pub_type
杂志文章abstract：:1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...
journal_title：Neurotoxicology and teratology
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abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...
journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
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doi：10.1016/j.ntt.2009.08.012
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.05.007
更新日期：2010-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(01)00182-9
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.04.054
更新日期：2010-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.08.008
更新日期：2010-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90028-7
更新日期：1989-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：1990-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90073-1
更新日期：1989-05-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
abstract：:Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2015.05.008
更新日期：2015-07-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2017.11.001
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.10.005
更新日期：2005-03-01 00:00:00
